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  • D3813 - Anti-DR4, N-Terminal antibody produced in rabbit

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D3813 Sigma

Anti-DR4, N-Terminal antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-Death Receptor 4, Anti-TRAIL-R1

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies to Death Receptors,
species reactivity   human
application(s)   microarray: suitable
  western blot: 0.5 μg/mL using human HeLa cell extract
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt approximately 57 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... TNFRSF10A(8797)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 1-20 of the N-terminal of the mature human DR4.

General description

DR4, referred to as TRAIL Receptor-1, is a novel death domain containing receptor whose ligand has been identified as TRAIL or apoptosis-inducing ligand 2 (Apo2L). It is a member of the TNF superfamily of receptors that induce apoptosis. It is expressed in most human tissues including spleen, peripheral blood leukocytes, small intestine, and thymus.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Application

Anti-DR4 antibody produced in rabbit is suitable for microarray and immunoblotting at a working dilution of 1:500-1:1000 using total HeLa, K562, and Jurkat whole cell lysates. It was used as a primary antibody in the immunodetection of DR4 in cell lysate of human small cell lung carcinoma cells. It was used as a primary antibody in the immunoblot analysis of fetal and adenocarcinoma epithelial colon cells in a study.

Features and Benefits

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Biochem/physiol Actions

DR4 induces apoptosis in a variety of human tumor cell lines, but not in normal cells and activates NF-κB.

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