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2′-Deoxycytidine (deoxyC) is one of the deoxynucleosides which after phosphorylation to dCTP is used to synthesis DNA via various DNA polymerases or reverse transcriptases. 2′-Deoxycytidine (deoxyC) is the substrate for deoxycytidine deaminase (EC 22.214.171.124) which converts it into 2′-deoxyuridine. 2′-Deoxycytidine is phosphorylated to the nucleotide dCMP by the enzyme deoxycytidine kinase (DCK).
Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release. Hazra S, Szewczak A, Ort S, Konrad M, Lavie A. Biochemistry 50, 2870-2880, (2011)
[Experimental study of remaxol as a drug for supportive therapy in traditional and high-dose treatment of tumors]. Bezborodova OA, Nemtsova ER, Venediktova IuB, et al. Eksp. Klin. Farmakol. 76(5), 18-22, (2013)
[A case of pancreatic body cancer with multiple liver metastases experiencing long-term response by gemcitabine plus erlotinib therapy]. Ohkawa S, Sakamoto Y, and Ueno M Gan To Kagaku Ryoho. 40(6), 785-8, (2013)
[A case of mediastinal lymph node gastric cancer recurrence during S-1 adjuvant therapy successfully treated with cisplatin + capecitabine as second-line chemotherapy]. Hirata A, Itatsu K, Fukaya M, et al. Gan To Kagaku Ryoho. 40(4), 519-22, (2013)
Rilpivirine versus efavirenz in HIV-1-infected subjects receiving emtricitabine/tenofovir DF: pooled 96-week data from ECHO and THRIVE Studies. Nelson MR, Elion RA, Cohen CJ, et al. HIV Clin. Trials 14(3), 81-91, (2013)
Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-cell lung cancer (FASTACT-2): a randomised, double-blind trial. Wu YL, Lee JS, Thongprasert S, et al. Lancet Oncol. 14(8), 777-86, (2013)
Virchow lymph node metastatic recurrence of sigmoid colon cancer with severe lymph node metastases successfully treated using systemic chemotherapy combined with radiotherapy. Ohchi T, Akagi Y, Kinugasa T, et al. Anticancer Res. 33(7), 2935-40, (2013)
Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease. Knutson CG, Mangerich A, Zeng Y, et al. Proc. Natl. Acad. Sci. U. S. A. 110(26), E2332-41, (2013)
[A case of HER2-positive gastric cancer successfully treated with trastuzumab plus capecitabine plus cisplatin chemotherapy as third-line treatment]. Murata Y, Matsuura T, Kanoshima K, et al. Gan To Kagaku Ryoho. 40(7), 933-6, (2013)
[A case of triple-negative breast cancer achieved pCR by epirubicin and cyclophosphamide(EC)therapy followed by gemcitabine plus paclitaxel combination preoperative therapy]. Saito M, Fujita S, Sakuma T, et al. Gan To Kagaku Ryoho. 40(5), 623-5, (2013)
An insight into potential of nanoparticles-assisted chemotherapy of cancer using gemcitabine and its fatty acid prodrug:a comparative study. Gupta A, Asthana S, Konwar R, et al. J. Biomed. Nanotechnol. 9(5), 915-25, (2013)
Phase 2 study of erlotinib combined with adjuvant chemoradiation and chemotherapy in patients with resectable pancreatic cancer. Herman JM, Fan KY, Wild AT, et al. Int. J. Radiat. Oncol. Biol. Phys. 86(4), 678-85, (2013)
Mitomycin-C and capecitabine (MIXE) as salvage treatment in patients with refractory metastatic colorectal cancer: a retrospective study. Saif MW, Kaley K, Brennan M, et al. Anticancer Res. 33(6), 2743-6, (2013)
Antiviral effect of orally administered (-)-beta-D-2-aminopurine dioxolane in woodchucks with chronic woodchuck hepatitis virus infection. Stephan Menne et al Antimicrob. Agents Chemother. 51, 3177-84, (2007)
The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase. Eisuke Murakami et al Antimicrob. Agents Chemother. 52, 458-64, (2008)
Deoxycytidine kinase is overexpressed in poor outcome breast cancer and determines responsiveness to nucleoside analogs. Geutjes EJ, Tian S, Roepman P, Bernards R. Breast Cancer Res. Treat. 131(3), 809-818, (2011)
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