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D3938 Sigma

Anti-DR5 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Death Receptor 5, Anti-KILLER, Anti-TRAIL-R2, Anti-TRICK2

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies to Death Receptors,
species reactivity   human
application(s)   microarray: suitable
  western blot: 2 μg/mL using human HeLa and K562 cell extracts
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 57 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... TNFRSF10B(8795)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 388-407 of the human DR5 precursor.

General description

DR5 is a death domain-containing receptor that is activated through a p53-depedent pathway in response to radiation and DNA damage . DR5 is involved in caspase activation and cell apoptosis . Anti-DR5 antibody is specific for DR5 in humans.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Application

Anti-DR5 antibody may be used in western blot (1 μg/mL using human HeLa and K562 cell extracts), immunoblot and microarray.

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