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D4022 Sigma

P1,P5-Di(adenosine-5′) pentaphosphate pentasodium salt

≥95% (HPLC), powder

Synonym: A(5′)P5(5′)A, Diadenosine pentaphosphate pentasodium salt

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates, Substrate Analogs More...
InChI Key   NNMFUJJMJIYTSP-CSMIRWGRSA-I
assay   ≥95% (HPLC)
form   powder
color   white to yellow-white
solubility   H2O: 50 mg/mL
storage temp.   −20°C

Description

Packaging

10, 25, 50 mg in poly bottle

2 mg in glass bottle

Biochem/physiol Actions

A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5′-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In cardiac muscle, pM to nM concentrations significantly increase the open-probability of ryanodine-receptor (RyR2) gates, with prolonged action due to slow dissociation from the receptor.

Price and Availability


Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
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Description

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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