Synonym: Cl2MDP, Clodronate disodium, Clodronic acid disodium salt, DMDP
|Related Categories||A to C, Anti-Proliferative Agents, Antitumor Agents, Application Index, Bioactive Small Molecules,|
|Gene Information||rat ... Man2a1(25478), Si(497756)|
Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma.1,2 When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver.3 Found also to inhibit collagenase and matrix metalloproteinase1.4
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Neurodegeneration Induced By PVC-211 Murine Leukemia Virus Is Associated With Increased Levels Of Vascular Endothelial Growth Factor And Macrophage Inflammatory Protein 1 Alpha And Is Inhibited By Blocking Activation Of Microglia. Li, X., et al. J. Virol. 83, 4912-22, (2009)
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