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D4641 Sigma

n-Dodecyl β-D-maltoside

≥98% (GC)

Synonym: DDM, Lauryl-β-D-maltoside

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Description

General description

n-Dodecyl β-D-maltoside is a surfactant. 5

Packaging

1, 5, 25 g in poly bottle

500 mg in poly bottle

Application

Non-ionic detergent for the stabilization and activation of enzymes and for membrane research.1,2,3,4

n-Dodecyl β-D-maltoside has been used in a study to assess the mapping of unfolding states of integral helical membrane proteins by GPS-NMR and scattering techniques. 5

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Safety & Documentation

Safety Information

WGK Germany 
3

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

1. Stability of rhodopsin in detergent solutions. P. Knudsen, W.L. Hubbell Membr. Biochem. 1, 297, (1978)

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2. W.J.de Grip, P.H.M. Bovee-Geurts Chem. Phys. Lipids 23, 321, (1979)

3. Alkyl glycoside detergents: a simpler synthesis and their effects on kinetic and physical properties of cytochrome c oxidase. P. Rosevear et al. Biochemistry 19, 4108, (1980)

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4. Alkyl glycoside detergents: synthesis and applications to the study of membrane proteins. T. VanAken et al. Meth. Enzymol. 125, 27, (1986)

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5. Mapping of unfolding states of integral helical membrane proteins by GPS-NMR and scattering techniques: TFE-induced unfolding of KcsA in DDM surfactant Calcutta, A., et al. Biochim. Biophys. Acta 1818, 2290, (2012)

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Purification and lipid dependence of the recombinant hyaluronan synthases from Streptococcus pyogenes and Streptococcus equisimilis. Tlapak-Simmons, V.L., et al. J. Biol. Chem. 274, 4239-4245, (1999)

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Purification of yeast cytochrome c oxidase with a subunit composition resembling the mammalian enzyme. Taanman, J.W., and Capaldi, R.A. J. Biol. Chem. 267, 22481-22485, (1992)

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Dye-ligand chromatographic purification of intact multisubunit membrane protein complexes: application to the chloroplast H+-FoF1-ATP synthase. Seelert, H. et al. Biochem. J. 346, 41-44, (2000)

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Effect of detergents and lipids on transducin photoactivation by rhodopsin. Bubis, J. Biol. Res. 31, 59, (1998)

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Kruip, J., et al. J. Biol. Chem. 274, 18181, (1991)

Role of detergents in conformational exchange of a G protein-coupled receptor. Chung KY, Kim TH, Manglik A, et al. J. Biol. Chem. 287(43), 36305-11, (2012)

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Revisiting the supramolecular organization of photosystem II in Chlamydomonas reinhardtii. Tokutsu R, Kato N, Bui KH, et al. J. Biol. Chem. 287(37), 31574-81, (2012)

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Evaluation of alkylmaltosides as intestinal permeation enhancers: comparison between rat intestinal mucosal sheets and Caco-2 monolayers. Petersen SB, Nolan G, Maher S, et al. Eur. J. Pharm. Sci. 47(4), 701-12, (2012)

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Electrochemistry, AFM, and PM-IRRA spectroscopy of immobilized hydrogenase: role of a hydrophobic helix in enzyme orientation for efficient H2 oxidation. Ciaccafava A, Infossi P, Ilbert M, et al. Angew. Chem. Int. Ed. Engl. 51(4), 953-6, (2012)

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A new high-performance thin layer chromatography-based assay of detergents and surfactants commonly used in membrane protein studies. Barret LA, Polidori A, Bonneté F, et al. J. Chromatogr. A 1281, 135-41, (2013)

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Sequence hydropathy dominates membrane protein response to detergent solubilization Nadeau, V., et al. Biochemistry 51, 6228, (2012)

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Salt bridge in the conserved His-Asp cluster in Gloeobacter rhodopsin contributes to trimer formation. Tsukamoto T, Kikukawa T, Kurata T, et al. FEBS Lett. 587(4), 322-7, (2013)

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PP3 forms stable tetrameric structures through hydrophobic interactions via the C-terminal amphipathic helix and undergoes reversible thermal dissociation and denaturation. Pedersen LR, Nielsen SB, Hansted JG, et al. FEBS J. 279(2), 336-47, (2012)

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Characterization of PSII-LHCII supercomplexes isolated from pea thylakoid membrane by one-step treatment with α- and β-dodecyl-D-maltoside. Barera S, Pagliano C, Pape T, et al. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 367(1608), 3389-99, (2012)

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pH regulation of the kinetic stability of the lipase from Thermomyces lanuginosus. Wang H, Andersen KK, Sehgal P, et al. Biochemistry 52(1), 264-76, (2013)

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Spectroscopic analysis of small multidrug resistance protein EmrE in the presence of various quaternary cation compounds. Bay DC and Turner RJ Biochim. Biophys. Acta 1818(5), 1318-31, (2012)

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Open and shut: crystal structures of the dodecylmaltoside solubilized mechanosensitive channel of small conductance from Escherichia coli and Helicobacter pylori at 4.4 Å and 4.1 Å resolutions. Lai JY, Poon YS, Kaiser JT, et al. Protein Sci. 22(4), 502-9, (2013)

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Characterization of the ground state dynamics of proteorhodopsin by NMR and optical spectroscopies. Stehle J, Scholz F, Löhr F, et al. J. Biomol. NMR 54(4), 401-13, (2012)

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Bindings of hMRP1 transmembrane peptides with dodecylphosphocholine and dodecyl-β-d-maltoside micelles: a molecular dynamics simulation study. Abel S, Lorieau A, de Foresta B, et al. Biochim. Biophys. Acta 1838(1 Pt B), 493-509, (2014)

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Evaluation of cell-free protein synthesis for the crystallization of membrane proteins--a case study on a member of the glutamate transporter family from Staphylothermus marinus. Jaehme M and Michel H FEBS J. 280(4), 1112-25, (2013)

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Characterization of photosystem I from spinach: effect of solution pH. Liu J, Zhang X, Wang M, et al. Photosynth. Res. 112(1), 63-70, (2012)

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Co(ii)-detection does not follow Kco(ii) gradient: channelling in Co(ii)-sensing. Patterson CJ, Pernil R, Dainty SJ, et al. Metallomics 5(4), 352-62, (2013)

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Single-molecule spectroscopy on RC-LH1 complexes of Rhodopseudomonas acidophila strain 10050. Böhm PS, Southall J, Cogdell RJ, et al. J. Phys. Chem. B 117(11), 3120-6, (2013)

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Novel ethoxylated inositol derivatives--hybrid carbohydrate/oligoethylene oxide surfactants. Catanoiu G, Blunk D, and Stubenrauch C J. Colloid. Interface Sci. 371(1), 82-8, (2012)

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Dilational surface rheology studies of n-dodecyl-β-D-maltoside, hexaoxyethylene dodecyl ether, and their 1:1 mixture. Boos J, Preisig N, and Stubenrauch C Adv. Colloid Interface Sci. 197-198, 108-17, (2013)

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Inhibition of cytotoxicity by the Nhe cytotoxin of Bacillus cereus through the interaction of dodecyl maltoside with the NheB component. Phung D, Granum PE, Dietrich R, et al. FEMS Microbiol. Lett. 330(2), 98-104, (2012)

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Topology anf function of CcmD in cytochrome c maturation. Richard-Fogal, C.L., et al. J. Bacteriol. 190, 3489, (2008)

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Competition of hydrophobic steroids with sodium dodecyl sulfate, dodecyltrimethylammonium bromide, or dodecyl β-D-maltoside for the dodecane/water interface. Feng S and Bummer PM Langmuir 28(49), 16927-32, (2012)

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Epithelial toxicity of alkylglycoside surfactants. Vllasaliu D, Shubber S, Fowler R, et al. J. Pharm. Sci. 102(1), 114-25, (2013)

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[D-Leu-4]-OB3, a synthetic peptide amide with leptin-like activity, augments the effects of orally delivered exenatide and pramlintide acetate on energy balance and glycemic control in insulin-resistant male C57BLK/6-m db/db mice. Leinung MC and Grasso P Regul. Pept. 179(1-3), 33-8, (2012)

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Structural and biochemical insight into glycogenin inactivation by the glycogenosis-causing T82M mutation. Carrizo ME, Romero JM, Issoglio FM, et al. FEBS Lett. 586(3), 254-7, (2012)

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Structural characterization of hydroperoxide lyase in dodecyl maltoside by using circular dichroism. Panagakou I, Touloupakis E, and Ghanotakis DF Protein J. 32(1), 1-6, (2013)

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Electrophoretic separation of purified myelin: a method to improve the protein pattern resolving. Ravera S, Bartolucci M, Barbarito G, et al. Prep Biochem Biotechnol. 43(4), 342-9, (2013)

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Beil. 17,V,8,12

FT-NMR 1 (1), 307:C / RegBook 1 (1), 197:C / Structure Index 1, 27:B:4

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