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D4902 Sigma

Dexamethasone

powder, BioReagent, suitable for cell culture, ≥97%

Synonym: (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Prednisolone F

  • CAS Number 50-02-2

  • Empirical Formula (Hill Notation) C22H29FO5

  • Molecular Weight 392.46

  •  Beilstein Registry Number 2066651

  •  EC Number 200-003-9

  •  MDL number MFCD00064136

  •  PubChem Substance ID 24893906

  • Popular Documents:  FTNMR (PDF)  

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Properties

Related Categories Bioactives and Supplements for Stem Cell Expansion, Bioactives/Supplements, Cell Biology, Cell Culture, Cell Signaling and Neuroscience,
product line   BioReagent
assay   ≥97%
form   powder
potency   4-500 ng/mL
mp   262-264 °C(lit.)
suitability   suitable for cell culture
storage temp.   2-8°C
Gene Information   human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)
rat ... Ar(24208), Nr3c1(24413), Tnf(24835)

Description

Frequently Asked Questions

Live Chat and Frequently Asked Questions are available for this Product.

Application

An anti-inflammatory glucocorticoid with a range of effects on cell survival, cell signaling and gene expression. Use to study apoptosis, cell signaling pathways and gene expression.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Reconstitution

To prepare 20 μg/ml stock solution, add 1ml absolute ethanol per mg product; gently swirl to dissolve. Add 49 ml sterile medium per ml of ethanol added, while mixing, to acheive final concentration of 20 μg/ml.

Physical form

powder 2-8 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Biochem/physiol Actions

Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
Safety Statements (Europe) 
22-26-36/37-45
WGK Germany 
2
RTECS 
TU3980000

Protocols & Articles

Articles

Mitochondrial Stress and ROS

Oxidative stress is implicated in the pathogenesis of lipotoxicity in both animal and human studies. Chronic oxidative stress is linked to insulin resistance in multiple tissues. Oxidative stress is ...
BioFiles 2011, 6.4, 22.
Keywords: Anti-inflammatory agents, Apoptosis, Cancer, Catalog, Cell signaling, Cellular processes, Gene expression, Indicators, Metabolism, Oxidations, Respiratory

Peer-Reviewed Papers

References

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Impact of perioperative dexamethasone on postoperative analgesia and side-effects: systematic review and meta-analysis. Waldron NH, Jones CA, Gan TJ, et al. Br. J. Anaesth. 110(2), 191-200, (2013)

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Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability. Martino MM, Mochizuki M, Rothenfluh DA, et al. Biomaterials 30(6), 1089-97, (2009)

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Dexamethasone to prevent postoperative nausea and vomiting: an updated meta-analysis of randomized controlled trials. De Oliveira GS, Castro-Alves LJ, Ahmad S, et al. Anesth. Analg. 116(1), 58-74, (2013)

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Intravitreal administration of dexamethasone-loaded PLGA-TPGS nanoparticles for the treatment of posterior segment diseases. Yang C, Jiang L, Bu S, et al. J. Biomed. Nanotechnol. 9(9), 1617-23, (2013)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Differential CD4+ T-lymphocyte apoptosis and bystander T-cell activation in rhesus macaques and sooty mangabeys during acute simian immunodeficiency virus infection. Meythaler M, Martinot A, Wang Z, et al. J. Virol. 83(2), 572-83, (2009)

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Induction and suppression of PEN3 focal accumulation during Pseudomonas syringae pv. tomato DC3000 infection of Arabidopsis. Xin XF, Nomura K, Underwood W, et al. Mol. Plant Microbe Interact. 26(8), 861-7, (2013)

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Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1. Venkata Lokesh Battula et al Haematologica 94, 173-84, (2009)

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Identifying off-target effects and hidden phenotypes of drugs in human cells. Marnie L MacDonald et al Nat. Chem. Biol. 2, 329-37, (2006)

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Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity. Mary Kaileh et al J. Biol. Chem. 282, 4253-64, (2007)

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Mesenchymal stem cell proliferation and differentiation on an injectable calcium phosphate-chitosan composite scaffold. Moreau JL Biomaterials 30(14), 2675-82, (2009)

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Polymerase I and transcript release factor regulates lipolysis via a phosphorylation-dependent mechanism. Aboulaich N Diabetes 60(3), 757-65, (2011)

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Determination of the fate and contribution of ex vivo expanded human bone marrow stem and progenitor cells for bone formation by 2.3ColGFP. Dezhong Yin et al Mol. Ther. 17, 1967-78, (2009)

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The Nup358-RanGAP complex is required for efficient importin α/β-dependent nuclear import. Saskia Hutten et al Mol. Biol. Cell 19, 2300-10, (2008)

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Soluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period. Vougogiannopoulou K J. Med. Chem. 51(20), 6421-31, (2008)

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Targeted inhibition of interleukin-6 with CNTO 328 sensitizes pre-clinical models of multiple myeloma to dexamethasone-mediated cell death. Peter M. Voorhees et al Br. J. Haematol. 145, 481-90, (2011)

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Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents. Tadashi Honda et al J. Med. Chem. 54, 1762-78, (2011)

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Reorganization of the nuclear lamina and cytoskeleton in adipogenesis. Verstraeten VL, Renes J, Ramaekers FC, et al. Histochem. Cell Biol. 135(3), 251-61, (2011)

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Hindbrain-derived Wnt and Fgf signals cooperate to specify the otic placode in Xenopus. Park BY and Saint-Jeannet JP Dev. Biol. 324(1), 108-21, (2008)

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Characterization of the drug binding specificity of rat liver fatty acid binding protein. Sara Chuang et al J. Med. Chem. 51, 3755-64, (2008)

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Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals. Markus A Lill et al J. Med. Chem. 48, 5666-74, (2005)

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Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells. Mehdi Shakibaei et al J. Biol. Chem. 286, 11492-505, (2011)

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Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability. Giorgio Ottaviani et al J. Med. Chem. 49, 3948-54, (2006)

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Fabrication of a neotrachea using engineered cartilage. Weidenbecher M Laryngoscope 118(4), 593-8, (2008)

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The living microarray: a high-throughput platform for measuring transcription dynamics in single cells. Rajan S, Djambazian H, Dang HC, et al. BMC Genomics 12, 115, (2011)

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QSAR study on permeability of hydrophobic compounds with artificial membranes. Masaaki Fujikawa et al Bioorg. Med. Chem. 15, 3756-67, (2007)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Discovery of potent, selective orally active, nonpeptide inhibitors of human mast cell chymase. Greco, M.N., et al. J. Med. Chem. 50, 1727-1730, (2007)

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Glucocorticoids Suppress Growth In Neonatal Cardiomyocytes Co-expressing AT(2) And AT(1) Angiotensin Receptors. Porrello, E.R., et al. Nat. Struct. Mol. Biol. 97, 257-65, (2010)

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Differentiating human multipotent mesenchymal stromal cells regulate microRNAs: prediction of microRNA regulation by PDGF during osteogenesis. Goff, LA Exp. Hematol. 36(10), 1354-1369, (2008)

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Synthesis and biological evaluation of simple methoxylated chalcones as anticancer, anti-inflammatory and antioxidant agents. Babasaheb P Bandgar et al Bioorg. Med. Chem. 18, 1364-70, (2010)

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Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. Robert Bucki et al Antimicrob. Agents Chemother. 54, 2525-33, (2010)

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Imaging progesterone receptor in breast tumors: synthesis and receptor binding affinity of fluoroalkyl-substituted analogues of tanaproget. Hai-Bing Zhou et al J. Med. Chem. 53, 3349-60, (2010)

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Molecular characteristics for solid-state limited solubility. Carola M Wassvik et al J. Med. Chem. 51, 3035-9, (2008)

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Potent inhibitors of pro-inflammatory cytokine production produced by a marine-derived bacterium. Wendy K Strangman et al J. Med. Chem. 52, 2317-27, (2009)

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Highly potent, orally available anti-inflammatory broad-spectrum chemokine inhibitors. David J Fox et al J. Med. Chem. 52, 3591-5, (2009)

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Identification of the bioactive constituent and its mechanisms of action in mediating the anti-inflammatory effects of black cohosh and related Cimicifuga species on human primary blood macrophages. Cindy L H Yang et al J. Med. Chem. 52, 6707-15, (2009)

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Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Manthena V S Varma et al J. Med. Chem. 53, 1098-108, (2010)

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Steroidal lactones as inhibitors of 17beta-hydroxysteroid dehydrogenase type 5: chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities. Patrick Bydal et al Eur. J. Med. Chem. 44, 632-44, (2009)

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Physicochemical determinants of human renal clearance. Manthena V S Varma et al J. Med. Chem. 52, 4844-52, (2009)

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Dexamethasone and cyclosporin A suppress mast cell-leukocyte cytokine cascades by multiple mechanisms. Wershil, B.K., et al. Int. Arch. Allergy Immunol. 107, 323-324, (1995)

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Pattern of IGF-1 variants' expression in human cancer cell lines using a novel q-RT-PCR approach. Christopoulos PF, Philippou A, and Koutsilieris M Anticancer Res. 35(1), 107-15, (2015)

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Unveiling adrenal insufficiency can make a difference in elderly adults. Kojima G, Laurel P, Inaba M, et al. J. Am. Geriatr. Soc. 62(12), 2456-7, (2014)

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Perineural vs intravenous administration of dexamethasone: more data are available. Albrecht E, Kern C, and Kirkham KR Br. J. Anaesth. 114(1), 160, (2015)

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Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma. Stewart AK, Rajkumar SV, Dimopoulos MA, et al. N. Engl. J. Med. 372(2), 142-52, (2015)

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IgE-dependent activation of human mast cells and fMLP-mediated activation of human eosinophils is controlled by the circadian clock. Baumann A, Feilhauer K, Bischoff SC, et al. Mol. Immunol. 64(1), 76-81, (2015)

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Pseudo-acute kidney injury secondary to intravenous dexamethasone. Nakajima M, Inoue T, Kato H, et al. Am. J. Kidney Dis. 65(2), 344, (2015)

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Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic phenotype and function. Wu HJ, Lo Y, Luk D, et al. Clin. Immunol. 156(1), 43-57, (2015)

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Safety and tolerability of ixazomib, an oral proteasome inhibitor, in combination with lenalidomide and dexamethasone in patients with previously untreated multiple myeloma: an open-label phase 1/2 study. Kumar SK, Berdeja JG, Niesvizky R, et al. Lancet Oncol. 15(13), 1503-12, (2014)

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Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance. Nowak D, Liem NL, Mossner M, et al. Exp. Hematol. 43(1), 32-43.e1-35, (2015)

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NFATc1 activity regulates the expression of myocilin induced by dexamethasone. Faralli JA, Clark RW, Filla MS, et al. Exp. Eye Res. 130, 9-16, (2015)

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Ghrelin augments murine T-cell proliferation by activation of the phosphatidylinositol-3-kinase, extracellular signal-regulated kinase and protein kinase C signaling pathways. Lee JH, Patel K, Tae HJ, et al. FEBS Lett. 588(24), 4708-19, (2014)

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Intravitreal controlled release of dexamethasone from engineered microparticles of porous silicon dioxide. Wang C, Hou H, Nan K, et al. Exp. Eye Res. 129, 74-82, (2014)

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Immunoglobulin light chain amyloidosis: 2014 update on diagnosis, prognosis, and treatment. Gertz MA Am. J. Hematol. 89(12), 1132-40, (2014)

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Phase 2 study of carfilzomib, thalidomide, and dexamethasone as induction/consolidation therapy for newly diagnosed multiple myeloma. Sonneveld P, Asselbergs E, Zweegman S, et al. Blood 125(3), 449-56, (2015)

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Phase II study of methotrexate, vincristine, pegylated-asparaginase, and dexamethasone (MOpAD) in patients with relapsed/refractory acute lymphoblastic leukemia. Kadia TM, Kantarjian HM, Thomas DA, et al. Am. J. Hematol. 90(2), 120-4, (2015)

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Possible role of lymphocytes in glucocorticoid-induced increase in trabecular bone mineral density. Grahnemo L, Jochems C, Andersson A, et al. J. Endocrinol. 224(1), 97-108, (2015)

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Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells. Jing D, Bhadri VA, Beck D, et al. Blood 125(2), 273-83, (2015)

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A retrospective study of acute mountain sickness on Mt. Kilimanjaro using trekking company data. Eigenberger P, Faino A, Maltzahn J, et al. Aviat. Space. Environ. Med. 85(11), 1125-9, (2014)

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Regulation of translation by upstream translation initiation codons of surfactant protein A1 splice variants. Tsotakos N, Silveyra P, Lin Z, et al. Am. J. Physiol. Lung Cell. Mol. Physiol. 308(1), L58-75, (2015)

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An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity. Gazzaniga FS and Blackburn EH Blood 124(25), 3675-84, (2014)

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REDD1 deletion prevents dexamethasone-induced skeletal muscle atrophy. Britto FA, Begue G, Rossano B, et al. Am. J. Physiol. Endocrinol. Metab. 307(11), E983-93, (2014)

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Aurothiomalate inhibits the expression of mPGES-1 in primary human chondrocytes. Tuure L, Hämäläinen M, Moilanen T, et al. Scand. J. Rheumatol. 44(1), 74-9, (2015)

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Metformin displays anti-myeloma activity and synergistic effect with dexamethasone in in vitro and in vivo xenograft models. Zi FM, He JS, Li Y, et al. Cancer Lett. 356(2 Pt B), 443-53, (2015)

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Melatonin ameliorates dexamethasone-induced inhibitory effects on the proliferation of cultured progenitor cells obtained from adult rat hippocampus. Ekthuwapranee K, Sotthibundhu A, Tocharus C, et al. J. Steroid Biochem. Mol. Biol. 145, 38-48, (2015)

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Molecular modulation of estrogen-induced apoptosis by synthetic progestins in hormone replacement therapy: an insight into the women's health initiative study. Sweeney EE, Fan P, and Jordan VC Cancer Res. 74(23), 7060-8, (2014)

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Ischemia postconditioning preventing lung ischemia-reperfusion injury. Cao QF, Qu MJ, Yang WQ, et al. Gene 554(1), 120-4, (2015)

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Hypothalamic-pituitary-adrenal axis in lethal canine Staphylococcus aureus pneumonia. Cortés-Puch I, Hicks CW, Sun J, et al. Am. J. Physiol. Endocrinol. Metab. 307(11), E994-E1008, (2014)

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Atomoxetine prevents dexamethasone-induced skeletal muscle atrophy in mice. Jesinkey SR, Korrapati MC, Rasbach KA, et al. J. Pharmacol. Exp. Ther. 351(3), 663-73, (2014)

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Intravitreal dexamethasone implant [Ozurdex] for the treatment of nonarteritic anterior ischaemic optic neuropathy. Alten F, Clemens CR, Heiduschka P, et al. Doc. Ophthalmol. 129(3), 203-7, (2014)

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JNK and IKKβ phosphorylation is reduced by glucocorticoids in adipose tissue from insulin-resistant rats. Motta K, Barbosa AM, Bobinski F, et al. J. Steroid Biochem. Mol. Biol. 145, 1-12, (2015)

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Postnatal glucocorticoid-induced hypomyelination, gliosis, and neurologic deficits are dose-dependent, preparation-specific, and reversible. Zia MT, Vinukonda G, Vose LR, et al. Exp. Neurol. 263, 200-13, (2015)

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Long-term effect of high-dose dexamethasone with or without low-dose dexamethasone maintenance in untreated immune thrombocytopenia. Din B, Wang X, Shi Y, et al. Acta Haematol. 133(1), 124-8, (2015)

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Mapracorat, a selective glucocorticoid receptor agonist, upregulates RelB, an anti-inflammatory nuclear factor-kappaB protein, in human ocular cells. Spinelli SL, Xi X, McMillan DH, et al. Exp. Eye Res. 127, 290-8, (2014)

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Multiple myeloma: 2014 Update on diagnosis, risk-stratification, and management. Vincent Rajkumar S Am. J. Hematol. 89(10), 999-1009, (2014)

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Multicenter study of intravitreal dexamethasone implant in noninfectious uveitis: indications, outcomes, and reinjection frequency. Zarranz-Ventura J, Carreño E, Johnston RL, et al. Am. J. Ophthalmol. 158(6), 1136-1145.e5, (2014)

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Long-term dexamethasone treatment alters the histomorphology of acinar cells in rat parotid and submandibular glands. Bighetti BB, d Assis GF, Vieira DC, et al. Int. J. Exp. Pathol. 95(5), 351-63, (2014)

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Current treatment for multiple myeloma. Avigan D and Rosenblatt J N. Engl. J. Med. 371(10), 961-2, (2014)

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Medication errors on oral chemotherapy in children with acute lymphoblastic leukemia in a developing country. Oberoi S, Trehan A, and Marwaha RK Pediatr. Blood Cancer 61(12), 2218-22, (2014)

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Bortezomib- and thalidomide-induced peripheral neuropathy in multiple myeloma: clinical and molecular analyses of a phase 3 study. Tacchetti P, Terragna C, Galli M, et al. Am. J. Hematol. 89(12), 1085-91, (2014)

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A randomized clinical trial of intravitreal bevacizumab versus intravitreal dexamethasone for diabetic macular edema: the BEVORDEX study. Gillies MC, Lim LL, Campain A, et al. Ophthalmology 121(12), 2473-81, (2014)

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[A patient with paclitaxel hypersensitivity treated with nab-paclitaxel]. Ouchi A, Ouchi A, Asano M, et al. Gan To Kagaku Ryoho. 41(7), 889-91, (2014)

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A syndecan-4 binding peptide derived from laminin 5 uses a novel PKCε pathway to induce cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells. Filla MS, Clark R, and Peters DM Exp. Cell Res. 327(2), 171-82, (2014)

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Von Willebrand Factor and Factor VIII levels in Egyptian children with newly diagnosed acute lymphoblastic leukemia in relation to peripheral blast cells and steroid therapy. El Sherif NH, Narouz MF, Elkerdany TA, et al. J. Pediatr. Hematol. Oncol. 36(7), 518-23, (2014)

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Rituximab-cyclophosphamide-dexamethasone is highly effective in patients with monoclonal Ig deposit-related glomerulopathy and indolent non-Hodgkin lymphomas. Perry M, Delarche A, Ribes D, et al. Am. J. Hematol. 89(10), 969-73, (2014)

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Analysis of gene expression for studying tumor progression: the case of glucocorticoid administration. Huerta M, Fernández-Márquez J, Cabello JL, et al. Gene 549(1), 33-40, (2014)

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Author reply: To PMID 24246828. Afshar AR and Stewart JM Ophthalmology 121(10), e57, (2014)

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Re: Afshar et al.: Dexamethasone intravitreal implant trapped at the macula in a silicone oil-filled eye (Ophthalmology 2013;120:2748-9). Banerjee PJ, Petrou P, and Charteris DG Ophthalmology 121(10), e55-7, (2014)

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Stability and removal of dexamethasone sodium phosphate from wastewater using modified clays. Sulaimana S, Khamis M, Nir S, et al. Environ. Technol. 35(13-16), 1945-55, (2014)

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Effectiveness of gemcitabine, pegaspargase, cisplatin, and dexamethasone (DDGP) combination chemotherapy in the treatment of relapsed/refractory extranodal NK/T cell lymphoma: a retrospective study of 17 patients. Zhou Z, Li X, Chen C, et al. Ann. Hematol. 93(11), 1889-94, (2014)

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Reply to T.L. Ng et al and L. Celio et al. Roila F, Fatigoni S, and Ballatori E J. Clin. Oncol. 32(20), 2187-8, (2014)

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Three-year, randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with diabetic macular edema. Boyer DS, Yoon YH, Belfort R, et al. Ophthalmology 121(10), 1904-14, (2014)

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Dexamethasone intravitreal implant in the treatment of persistent uveitic macular edema in the absence of active inflammation. Cao JH, Mulvahill M, Zhang L, et al. Ophthalmology 121(10), 1871-6, (2014)

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Carfilzomib, cyclophosphamide, and dexamethasone in patients with newly diagnosed multiple myeloma: a multicenter, phase 2 study. Bringhen S, Petrucci MT, Larocca A, et al. Blood 124(1), 63-9, (2014)

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Perineural dexamethasone and multimodal perineural analgesia: how much is too much? Williams BA, Schott NJ, Mangione MP, et al. Anesth. Analg. 118(5), 912-4, (2014)

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Efficacy of betamethasone on the fetal motion and biophysical profile and amniotic fluid index in preterm fetuses. Abbasalizadeh S, Pharabar ZN, Abbasalizadeh F, et al. Pak. J. Biol. Sci. 16(22), 1569-73, (2013)

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[Rapidly progressive AL amyloidosis in a patient with relapsed multiple myeloma after achieving a complete response to tandem autologous PBSCT]. Yagi H, Ozaki S, Sekimoto E, et al. Rinsho. Ketsueki. 54(12), 2171-6, (2013)

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[New and old medications for croup and seizures in children. Oral dexamethasone and buccal midazolam may provide better treatment]. Inge A and Nasta F Lakartidningen. 110(48), 2163, (2013)

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[Serious organ damage and intractable clinical conditions in rheumatic and connective tissue disease--progress in pathophysiology and treatment. Topics: II. Clinical conditions special attention needed to be paid to; 4. Macrophage activating syndrome and hemophagocytic syndrome]. Komagata Y Nippon. Naika Gakkai Zasshi. 102(10), 2639-44, (2013)

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[Management of comorbid diabetes and cancer in the elderly]. Ohashi K Nihon Rinsho. 71(11), 2038-42, (2013)

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Stopping the swinging pendulum of postnatal corticosteroid use. Demauro SB, Dysart K, and Kirpalani H J. Pediatr. 164(1), 9-11, (2014)

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Hyperkalemia: a clue to the diagnosis of adrenal insufficiency. El Fassi D and Nielsen G Circulation 128(24), 2620-1, (2013)

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Recurrent Central Serous Chorioretinopathy with Dexamethasone Eye Drop used Nasally for Rhinitis. Prakash G, Shephali J, Tirupati N, et al. Middle East Afr. J. Ophthalmol. 20(4), 363-5, (2013)

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Single high-dose dexamethasone and sodium salicylate failed to attenuate phosgene-induced acute lung injury in rats. Liu F, Pauluhn J, Trübel H, et al. Toxicology 315, 17-23, (2014)

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A pilot study in rhesus macaques to assess the treatment efficacy of a small molecular weight catalytic metalloporphyrin antioxidant (AEOL 10150) in mitigating radiation-induced lung damage. Garofalo MC, Ward AA, Farese AM, et al. Health Phys. 106(1), 73-83, (2014)

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The delayed pulmonary syndrome following acute high-dose irradiation: a rhesus macaque model. Garofalo M, Bennett A, Farese AM, et al. Health Phys. 106(1), 56-72, (2014)

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Question 1: Prednisolone or dexamethasone for acute exacerbations of asthma: do they have similar efficacy in the management of exacerbations of childhood asthma? Redman E and Powell C Arch. Dis. Child. 98(11), 916-9, (2013)

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Light chain deposition. Hsia CC and Chan NG Blood 121(26), 5111, (2013)

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[Rapid improvement of fluid retention with lenalidomide plus low-dose dexamethasone for POEMS syndrome relapsed after autologous peripheral blood stem cell transplantation]. Ohashi K, Yokoyama A, Kagoo T, et al. Rinsho. Ketsueki. 54(7), 670-4, (2013)

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[Comparison of antiemesis effects of granisetron, aprepitant and dexamethasone to palonosetron, aprepitant and dexamethasone in treatment of high-emetic risk chemotherapy-induced nausea and vomiting - a retrospective study for efficacy and safety in a single institute]. Osawa H, Goto H, and Myojo T Gan To Kagaku Ryoho. 40(5), 617-21, (2013)

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Stopping trials early. Myles PS Br. J. Anaesth. 111(2), 133-5, (2013)

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Dexamethasone added to bupivacaine prolongs duration of epidural analgesia. Naghipour B, Aghamohamadi D, Azarfarin R, et al. Middle East J. Anesthesiol. 22(1), 53-7, (2013)

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[The combination of chronic myeloid leukemia and multiple myeloma in one patient]. Romanenko NA, Bessmel'tsev SS, Udal'eva VIu, et al. Vopr. Onkol. 59(2), 103-10, (2013)

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A case of extramedullary plasmablastic plasmacytoma successfully treated using a combination of thalidomide and dexamethasone and a review of the medical literature. Sekiguchi Y, Asahina T, Shimada A, et al. J. Clin. Exp. Hematop. 53(1), 21-8, (2013)

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Retinoic acid syndrome--cardiac complication. Dhar AK and Barman PK J. Assoc. Physicians India 60, 63-5, (2012)

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Clinically relevant genetic advances in endocrinology. Rogers A and Thakker RV Clin. Med. 13(3), 299-305, (2013)

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A novel mechanism for glucocorticoid-induced tightening of endothelial barriers. Duh EJ Invest. Ophthalmol. Vis. Sci. 54(6), 4016, (2013)

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Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Lei Du-Cuny et al Bioorg. Med. Chem. 17, 6983-92, (2009)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Discovery of Potent, Selective, and Orally Bioavailable Alkynylphenoxyacetic Acid CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases Crosignani, S.; et al. J. Med. Chem. 20th ed., 54, 7299-7317, (2011)

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Dexamethasone for antiemesis in laparoscopic gynecologic surgery: a systematic review and meta-analysis. Pham A and Liu G Obstet. Gynecol. 120(6), 1451-8, (2012)

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Synthesis and biological evaluation of a novel series of pyrazole chalcones as anti-inflammatory, antioxidant and antimicrobial agents. Babasaheb P Bandgar et al Bioorg. Med. Chem. 17, 8168-73, (2009)

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Synthesis and biochemical characterization of a series of 17?-perfluoroalkylated estradiols as selective ligands for estrogen receptor ?. Barbara Eignerová et al J. Med. Chem. 53, 6947-53, (2010)

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Discovery and optimization of novel 3-piperazinylcoumarin antagonist of chemokine-like factor 1 with oral antiasthma activity in mice. Gang Li et al J. Med. Chem. 53, 1741-54, (2010)

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High-throughput evaluation of relative cell permeability between peptoids and peptides. Niclas C Tan et al Bioorg. Med. Chem. 16, 5853-61, (2008)

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Microbial transformation of isosteviol and bioactivities against the glucocorticoid/androgen response elements. Shwu-Fen Chang et al J. Nat. Prod. 71, 87-92, (2008)

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cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia. Huaqing Liu et al J. Med. Chem. 51, 7094-8, (2008)

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Nonsteroidal dissociated glucocorticoid agonists containing azaindoles as steroid A-ring mimetics. Doris Riether et al J. Med. Chem. 53, 6681-98, (2010)

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Novel synthesis of the hexahydroimidazo[1,5b]isoquinoline scaffold: application to the synthesis of glucocorticoid receptor modulators. Hai-Yun Xiao et al J. Med. Chem. 53, 1270-80, (2010)

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Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis. Tsutomu Akama et al Bioorg. Med. Chem. Lett. 19, 2129-32, (2009)

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Convergent Functional Genomics Of Oligodendrocyte Differentiation Identifies Multiple Autoinhibitory Signaling Circuits. Gobert, R.P., et al. Mol. Cell. Endocrinol. 29, 1538-53, (2009)

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Synthesis and biological evaluation of a novel series of 2,2-bisaminomethylated aurone analogues as anti-inflammatory and antimicrobial agents. Babasaheb P Bandgar et al Eur. J. Med. Chem. 45, 3223-7, (2010)

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Glucocorticoids differentially regulate degradation of MyoD and Id1 by N-terminal ubiquitination to promote muscle protein catabolism. Liping Sun et al Proc. Natl. Acad. Sci. U. S. A. 105, 3339-44, (2008)

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Trifluoromethyl group as a pharmacophore: effect of replacing a CF3 group on binding and agonist activity of a glucocorticoid receptor ligand. Raj Betageri et al Bioorg. Med. Chem. Lett. 15, 4761-9, (2005)

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Chisopanins A-K, 11 new protolimonoids from Chisocheton paniculatus and their anti-inflammatory activities. Ming-Hua Yang et al Bioorg. Med. Chem. 19, 1409-17, (2011)

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Identification and characterization of acidic mammalian chitinase inhibitors. Derek C Cole et al J. Med. Chem. 53, 6122-8, (2010)

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IFN-gamma reverses IL-2- and IL-4-mediated T-cell steroid resistance. Goleva E Am. J. Respir. Cell. Mol. Biol. 40(2), 223-30, (2009)

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Design and synthesis of new nonsteroidal glucocorticoid modulators through application of an "agreement docking" method. Mike Barker et al J. Med. Chem. 48, 4507-10, (2005)

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Potential anti-inflammatory constituents of the stems of Gordonia chrysandra. Hui-Zheng Fu et al J. Nat. Prod. 74, 1066-72, (2011)

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Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. Roland W Bürli et al Bioorg. Med. Chem. Lett. 16, 3713-8, (2006)

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The novel 3,4-dihydropyrimidin-2(1H)-one urea derivatives of N-aryl urea: synthesis, anti-inflammatory, antibacterial and antifungal activity evaluation. Rajesh H Tale et al Bioorg. Med. Chem. Lett. 21, 4648-51, (2011)

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Mesenchymal stem cells improve wound healing in vivo via early activation of matrix metalloproteinase-9 and vascular endothelial growth factor. Kim CH J. Korean Med. Sci. 26(6), 726-33, (2011)

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Synthesis and biological evaluation of beta-chloro vinyl chalcones as inhibitors of TNF-alpha and IL-6 with antimicrobial activity. Babasaheb P Bandgar et al Eur. J. Med. Chem. 45, 2629-33, (2010)

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Design and synthesis of boron-containing PDE4 inhibitors using soft-drug strategy for potential dermatologic anti-inflammatory application. Yong-Kang Zhang et al Bioorg. Med. Chem. Lett. 20, 2270-4, (2010)

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Synthesis and biological screening of a combinatorial library of beta-chlorovinyl chalcones as anticancer, anti-inflammatory and antimicrobial agents. Babasaheb P Bandgar et al Bioorg. Med. Chem. 18, 2060-5, (2010)

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The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144. Deborah M Roll et al J. Nat. Prod. 72, 1944-8, (2009)

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Design, synthesis, and pharmacological evaluation of novel hybrid compounds to treat sickle cell disease symptoms. Jean Leandro dos Santos et al J. Med. Chem. 54, 5811-9, (2011)

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Antinociceptive properties of bergenin. Cristiane Metzker de Oliveira et al J. Nat. Prod. 74, 2062-8, (2011)

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Transformation of isosteviol lactam by fungi and the suppressive effects of its transformed products on LPS-induced iNOS expression in macrophages. Bo-Hon Chou et al J. Nat. Prod. 74, 1379-85, (2011)

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Blockade of IL-6 secretion pathway by the sesquiterpenoid atractylenolide III. Tae-Hee Kang et al J. Nat. Prod. 74, 223-7, (2011)

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PlGF repairs myocardial ischemia through mechanisms of angiogenesis, cardioprotection and recruitment of myo-angiogenic competent marrow progenitors. Iwasaki H, Kawamoto A, Tjwa M, et al. PLoS ONE 6(9), e24872, (2011)

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Synthesis and evaluation of pyrazolo[3,4-b]pyridines and its structural analogues as TNF-alpha and IL-6 inhibitors. Sandip B Bharate et al Bioorg. Med. Chem. 16, 7167-76, (2008)

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Development of a second generation of inhibitors of microsomal prostaglandin E synthase 1 expression bearing the gamma-hydroxybutenolide scaffold. Maurizio Aquino et al Bioorg. Med. Chem. 16, 9056-64, (2008)

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Synthesis and characterization of nonsteroidal glucocorticoid receptor modulators for multiple myeloma. Andrew R Hudson et al J. Med. Chem. 50, 4699-709, (2007)

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Core exploration in optimization of chemokine receptor CCR4 antagonists. Ashok V Purandare et al Bioorg. Med. Chem. Lett. 17, 679-82, (2007)

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Quinol-4-ones as steroid A-ring mimetics in nonsteroidal dissociated glucocorticoid agonists. John Regan et al J. Med. Chem. 49, 7887-96, (2006)

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2-Amino-5-thiazolyl motif: a novel scaffold for designing anti-inflammatory agents of diverse structures. P X Franklin et al Eur. J. Med. Chem. 43, 129-34, (2008)

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Constitutional flavonoids derived from Epimedium dose-dependently reduce incidence of steroid-associated osteonecrosis not via direct action by themselves on potential cellular targets. Zhang, G PLoS ONE 4(7), e6419, (2009)

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Structure Guided Design of 5-Arylindazole Glucocorticoid Receptor Agonists and Antagonists C. M. Yates, et al. J. Med. Chem. 53, 4531-4544, (2010)

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Microbial transformation of isosteviol oxime and the inhibitory effects on NF-kappaB and AP-1 activation in LPS-stimulated macrophages. Shwu-Fen Chang et al Bioorg. Med. Chem. 17, 6348-53, (2009)

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Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins. Alfonso Pérez-Garrido et al Bioorg. Med. Chem. 17, 896-904, (2009)

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Dexamethasone, but not meloxicam, suppresses proliferation of bovine CD25+ CD4+ and CD25- CD4+ T cells. Maślanka T and Jaroszewski JJ Pol. J. Vet. Sci. 16(2), 219-22, (2013)

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Nanosponges encapsulating dexamethasone for ocular delivery: formulation design, physicochemical characterization, safety and corneal permeability assessment. Swaminathan S, Vavia PR, Trotta F, et al. J. Biomed. Nanotechnol. 9(6), 998-1007, (2013)

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Syntheses of immunomodulating androstanes and stigmastanes: comparison of their TNF-alpha inhibitory activity. Javier A Ramírez et al Bioorg. Med. Chem. 15, 7538-44, (2007)

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Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships. Shigeo Hayashi et al Bioorg. Med. Chem. 18, 7675-99, (2010)

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Synthesis and biological evaluation of nitrogen-containing benzophenone analogues as TNF-alpha and IL-6 inhibitors with antioxidant activity. Babasaheb P Bandgar et al Bioorg. Med. Chem. Lett. 20, 2292-6, (2010)

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Infection with Hymenolepis diminuta is more effective than daily corticosteroids in blocking chemically induced colitis in mice. Melon A J. Biomed. Biotechnol. 2010, 384523, (2010)

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T cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival. Moro H, Otero DC, Tanabe Y, et al. PLoS ONE 6(9), e24972, (2011)

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Effects of ?-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro. Liuqiang Zhang et al Bioorg. Med. Chem. 19, 4882-6, (2011)

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Non-steroidal glucocorticoid agonists: the discovery of aryl pyrazoles as A-ring mimetics. Margaret Clackers et al Bioorg. Med. Chem. Lett. 17, 4737-45, (2007)

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Androgen resistance in squirrel monkeys (Saimiri spp.). Gross KL Comp. Med. 58(4), 381-8, (2008)

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1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors. Olga Bruno et al Bioorg. Med. Chem. 17, 3379-87, (2009)

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Transformation of steviol-16alpha,17-epoxide by Streptomyces griseus and Cunninghamella bainieri. Shwu-Fen Chang et al J. Nat. Prod. 69, 1450-5, (2006)

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α-Methyltryptamine sulfonamide derivatives as novel glucocorticoid receptor ligands Marshall, D. R.; et al. Bioorg. Med. Chem. Lett. 17, 315, (2007)

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Investigation of the relative cellular permeability of DNA-binding pyrrole-imidazole polyamides. Bo Liu et al J. Med. Chem. 52, 4604-12, (2009)

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Comparison of changes in gene expression of transferrin receptor-1 and other iron-regulatory proteins in rat liver and brain during acute-phase response. Ihtzaz Ahmed Malik et al Cell Tissue Res. 344, 299-312, (2011)

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QSAR-based permeability model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 19, 2615-24, (2011)

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6-amino-4-oxo-1,3-diphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl derivatives as a new class of potent inhibitors of Interleukin-8-induced neutrophil chemotaxis. Sara Cesarini et al Bioorg. Med. Chem. 17, 3580-7, (2009)

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Synthesis and biological evaluation of N-pyrazolyl-N'-alkyl/benzyl/phenylureas: a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis. Olga Bruno et al J. Med. Chem. 50, 3618-26, (2007)

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Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Yong-Hua Wang et al Bioorg. Med. Chem. Lett. 15, 4076-84, (2005)

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Alkaloids from the Australian rainforest tree Ochrosia moorei. Anthony R Carroll et al J. Nat. Prod. 71, 1063-5, (2008)

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Neural computational prediction of oral drug absorption based on CODES 2D descriptors. A Guerra et al Eur. J. Med. Chem. 45, 930-40, (2010)

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Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators. Bingwei V Yang et al Bioorg. Med. Chem. Lett. 19, 2139-43, (2009)

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Trimethylsilylpyrazoles as novel inhibitors of p38 MAP kinase: a new use of silicon bioisosteres in medicinal chemistry. Matthew J Barnes et al Bioorg. Med. Chem. Lett. 17, 354-7, (2007)

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Tetrahydroquinolines as a novel series of nonsteroidal selective androgen receptor modulators: structural requirements for better physicochemical and biological properties. Naoya Nagata et al Bioorg. Med. Chem. Lett. 21, 6310-3, (2011)

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Mifepristone Increases Gamma-retroviral Infection Efficiency By Enhancing The Integration Of Virus Into The Genome Of Infected Cells. Solodushko, V., and Fouty, B. Gene Ther. 17, 1253-61, (2010)

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Augmented post-remission therapy for a minimal residual disease-defined high-risk subgroup of children and young people with clinical standard-risk and intermediate-risk acute lymphoblastic leukaemia (UKALL 2003): a randomised controlled trial. Vora A, Goulden N, Mitchell C, et al. Lancet Oncol. 15(8), 809-18, (2014)

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Cutting edge: Dexamethasone potentiates the responses of both regulatory T cells and B-1 cells to antigen immunization in the ApoE(-/-) mouse model of atherosclerosis. Chen A, Geng Y, Ke H, et al. J. Immunol. 193(1), 35-9, (2014)

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Treatment outcome in children and adolescents with relapsed Hodgkin lymphoma--results of the UK HD3 relapse treatment strategy. Shankar A, Hayward J, Kirkwood A, et al. Br. J. Haematol. 165(4), 534-44, (2014)

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The effects of perineural versus intravenous dexamethasone on sciatic nerve blockade outcomes: a randomized, double-blind, placebo-controlled study. Rahangdale R, Kendall MC, McCarthy RJ, et al. Anesth. Analg. 118(5), 1113-9, (2014)

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Long-term plasmapheresis in conjunction with thalidomide and dexamethasone for the treatment of cutaneous ulcers and neovascular glaucoma in recalcitrant type I cryoglobulinemia. Yang CH, Qureshi AA, Churchill WH, et al. JAMA Dermatol. 150(4), 426-8, (2014)

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Dexamethasone and risk of bleeding in children undergoing tonsillectomy. Mahant S, Keren R, Localio R, et al. Otolaryngol. Head Neck Surg. 150(5), 872-9, (2014)

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A prospective study of anxiety, depression, and behavioral changes in the first year after a diagnosis of childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. Myers RM, Balsamo L, Lu X, et al. Cancer 120(9), 1417-25, (2014)

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Effects of dexamethasone as a local anaesthetic adjuvant for brachial plexus block: a systematic review and meta-analysis of randomized trials. Choi S, Rodseth R, and McCartney CJ Br. J. Anaesth. 112(3), 427-39, (2014)

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Dexras1 mediates glucocorticoid-associated adipogenesis and diet-induced obesity. Cha JY, Kim HJ, Yu JH, et al. Proc. Natl. Acad. Sci. U. S. A. 110(51), 20575-80, (2013)

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Lenalidomide plus dexamethasone for high-risk smoldering multiple myeloma. Mateos MV, Hernández MT, Giraldo P, et al. N. Engl. J. Med. 369(5), 438-47, (2013)

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Discovery of quinolines as selective glucocorticoid receptor agonists. Stefan Jaroch et al Bioorg. Med. Chem. Lett. 20, 5835-8, (2010)

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Evaluation of T and B lymphocyte function in clinical practice using a flow cytometry based proliferation assay. Marits P, Wikström AC, Popadic D, et al. Clin. Immunol. 153(2), 332-42, (2014)

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Relative adrenal insufficiency in mice deficient in 5α-reductase 1. Livingstone DE, Di Rollo EM, Yang C, et al. J. Endocrinol. 222(2), 257-66, (2014)

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Adrenal steroidogenesis following prenatal dexamethasone exposure in the spiny mouse. Quinn TA, Ratnayake U, Castillo-Melendez M, et al. J. Endocrinol. 221(2), 347-62, (2014)

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Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)

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Discovery of a potent series of non-steroidal non ?-trifluoromethyl carbinol glucocorticoid receptor agonists with reduced lipophilicity. Hawa Diallo et al Bioorg. Med. Chem. Lett. 21, 1126-33, (2011)

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Dexamethasone plus somatostatin-analog manipulation as bone metastasis microenvironment-targeting therapy for the treatment of castration-resistant prostate cancer: a meta-analysis of uncontrolled studies. Toulis KA, Goulis DG, Msaouel P, et al. Anticancer Res. 32(8), 3283-9, (2012)

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Vision-related functioning outcomes of dexamethasone intravitreal implant in noninfectious intermediate or posterior uveitis. Lightman S, Belfort R, Naik RK, et al. Invest. Ophthalmol. Vis. Sci. 54(7), 4864-70, (2013)

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Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. Nidhi Puri et al Eur. J. Med. Chem. 45, 4813-26, (2010)

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5-Functionalized indazoles as glucocorticoid receptor agonists. Mei Bai et al Bioorg. Med. Chem. Lett. 20, 3017-20, (2010)

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Suppression of nitric oxide induction and pro-inflammatory cytokines by novel proteasome inhibitors in various experimental models. Asaf A Qureshi et al Lipids Health Dis. 10, 177, (2011)

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Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle. Feillet C, Krusche P, Tamanini F, et al. Proc. Natl. Acad. Sci. U. S. A. 111(27), 9828-33, (2014)

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Mast cells prevent dexamethasone-induced cell death of cultured fibroblasts: relationship to gap junctional intercellular communications. Foley TT and Ehrlich HP Plast. Reconstr. Surg. 133(5), 638e-644e, (2014)

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Culture of mouse embryonic stem cells with serum but without exogenous growth factors is sufficient to generate functional hepatocyte-like cells. Karen Pauwelyn et al PLoS ONE 6, e23096, (2011)

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Modulation of glucocorticoid receptor induction properties by cofactors in peripheral blood mononuclear cells. Luo M and Simons SS Hum. Immunol. 70(10), 785-9, (2009)

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Mesenchymal stromal cell proliferation, gene expression and protein production in human platelet-rich plasma-supplemented media. Amable PR, Teixeira MV, Carias RB, et al. PLoS ONE 9(8), e104662, (2014)

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Haploinsufficiency of Def activates p53-dependent TGFβ signalling and causes scar formation after partial hepatectomy. Zhu Z, Chen J, Xiong JW, et al. PLoS ONE 9(5), e96576, (2014)

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Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. Pil H Lee et al Bioorg. Med. Chem. Lett. 20, 69-73, (2010)

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Phenolic substances from Phagnalon rupestre protect against 2,4,6-trinitrochlorobenzene-induced contact hypersensitivity. Elisa Giner et al J. Nat. Prod. 74, 1079-84, (2011)

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Non-steroidal dissociated glucocorticoid agonists: indoles as A-ring mimetics and function-regulating pharmacophores. Raj Betageri et al Bioorg. Med. Chem. Lett. 21, 6842-51, (2011)

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Design and synthesis of tricyclic tetrahydroquinolines as a new series of nonsteroidal selective androgen receptor modulators (SARMs). Naoya Nagata et al Bioorg. Med. Chem. Lett. 21, 1744-7, (2011)

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Lenalidomide and dexamethasone in transplant-ineligible patients with myeloma. Benboubker L, Dimopoulos MA, Dispenzieri A, et al. N. Engl. J. Med. 371(10), 906-17, (2014)

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Role of dexamethasone in the prevention of migraine recurrence in the acute care setting: a review. Giuliano C, Smalligan RD, Mitchon G, et al. Postgrad. Med. 124(3), 110-5, (2012)

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High-dose chemotherapy plus autologous stem-cell transplantation as consolidation therapy in patients with relapsed multiple myeloma after previous autologous stem-cell transplantation (NCRI Myeloma X Relapse [Intensive trial]): a randomised, open-label, phase 3 trial. Cook G, Williams C, Brown JM, et al. Lancet Oncol. 15(8), 874-85, (2014)

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Dexamethasone and haemorrhage risk in paediatric tonsillectomy: a systematic review and meta-analysis. Bellis JR, Pirmohamed M, Nunn AJ, et al. Br. J. Anaesth. 113(1), 23-42, (2014)

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Confirmation of the mantle-cell lymphoma International Prognostic Index in randomized trials of the European Mantle-Cell Lymphoma Network. Hoster E, Klapper W, Hermine O, et al. J. Clin. Oncol. 32(13), 1338-46, (2014)

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Lipid raft- and protein kinase C-mediated synergism between glucocorticoid- and gonadotropin-releasing hormone signaling results in decreased cell proliferation. Wehmeyer L, Du Toit A, Lang DM, et al. J. Biol. Chem. 289(14), 10235-51, (2014)

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Inhibition of COX-1 activity and COX-2 expression by 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid and its semi-synthetic derivatives. Salvatore Genovese et al Bioorg. Med. Chem. Lett. 21, 5995-8, (2011)

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Ciprofloxacin 0.3% + dexamethasone 0.1% for the treatment for otitis media. Kutz JW, Roland PS, and Lee KH Expert Opin. Pharmacother. 14(17), 2399-405, (2013)

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Response to: "Possible errors in hearing recovery results" from Kai-Min Fang. Lim HJ, Kim YT, Park HY, et al. Otolaryngol. Head Neck Surg. 148(6), 1063, (2013)

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Possible errors in hearing recovery results. Sung PH and Fang KM Otolaryngol. Head Neck Surg. 148(6), 1062, (2013)

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Development of a surface plasmon resonance biosensor for real-time detection of osteogenic differentiation in live mesenchymal stem cells. Yi-Chun Kuo et al PLoS ONE 6, e22382, (2011)

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Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes. Zhang Y Lipids Health Dis. 10, 122, (2011)

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[Hyperammonemic encephalopathy in multiple myeloma]. Oestmann A and Aujesky D Dtsch. Med. Wochenschr. 139(30), 1518-20, (2014)

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Spectrophotometric determination of drugs with iodine. Karuna T, et al. J. Sci. Ind. Res. 65(10), 808, (2006)

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Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucoma. Zode GS, Sharma AB, Lin X, et al. J. Clin. Invest. 124(5), 1956-65, (2014)

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Stringent complete remission of primary plasma cell leukemia with reduced-dose bortezomib, lenalidomide and dexamethasone: a case report and review of the literature. Ueda S, Kubo M, Matsuura N, et al. Intern. Med. 52(11), 1235-8, (2013)

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Dexamethasone-eluting vascular stents. Hämäläinen M, Nieminen R, Uurto I, et al. Basic Clin Pharmacol Toxicol. 112(5), 296-301, (2013)

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Congenital nasal pyriform aperture stenosis: conservative management. Collins B, Powitzky R, Enix J, et al. Ann. Otol. Rhinol. Laryngol. 122(10), 601-4, (2013)

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Aprepitant versus dexamethasone to prevent delayed emesis after chemotherapy. Ng TL, Clemons M, Hutton B, et al. J. Clin. Oncol. 32(20), 2184-5, (2014)

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IL-1β induction of MUC5AC gene expression is mediated by CREB and NF-κB and repressed by dexamethasone. Chen Y, Garvin LM, Nickola TJ, et al. Am. J. Physiol. Lung Cell. Mol. Physiol. 306(8), L797-807, (2014)

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Selective Transcriptional Regulation Of Aromatase Gene By Vitamin D, Dexamethasone, And Mifepristone In Human Glioma Cells. Yague, J.G., et al. Endocrinol. Relat. Cancer 35, 252-61, (2009)

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The critical role of IL-34 in osteoclastogenesis. Zhi Chen et al PLoS ONE 6, e18689, (2011)

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Neuronal Fos-like immunoreactivity associated with dexamethasone-induced hypertension in rats and effects of glucagon-like peptide-2. Sasaki-Hamada S, Ito K, and Oka J Life Sci. 93(23), 889-96, (2013)

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Antemortem diagnosis and successful management of noncompressive segmental myelopathy in a Siberian-Bengal mixed breed tiger. Flower JE, Lynch K, Clark-Price SC, et al. J. Zoo Wildl. Med. 44(4), 1115-9, (2013)

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Corticosteroids reverse cytokine-induced block of survival and differentiation of oligodendrocyte progenitor cells from rats. Mann SA J. Neuroinflammation 5, 39, (2008)

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The research on the immuno-modulatory defect of mesenchymal stem cell from Chronic Myeloid Leukemia patients. Zhu Xishan et al J. Exp. Clin. Cancer Res 30, 47, (2011)

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Regulatory network analyses reveal genome-wide potentiation of LIF signaling by glucocorticoids and define an innate cell defense response. Langlais D PLoS Genet. 4(10), e1000224, (2008)

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Roles for the mitogen-activated protein kinase (MAPK) phosphatase, DUSP1, in feedback control of inflammatory gene expression and repression by dexamethasone. Shah S, King EM, Chandrasekhar A, et al. J. Biol. Chem. 289(19), 13667-79, (2014)

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Choice of glucocorticoid in HELLP syndrome - dexamethasone versus betamethasone: revisiting the dilemma. Basaran A, Basaran M, and Sen C J. Matern. Fetal. Neonatal. Med. 25(12), 2597-600, (2012)

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Heme exporter FLVCR1a regulates heme synthesis and degradation and controls activity of cytochromes P450. Vinchi F, Ingoglia G, Chiabrando D, et al. Gastroenterology 146(5), 1325-38, (2014)

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Post-transplantation consolidation and maintenance therapy with lenalidomide for Japanese patients with multiple myeloma. Takamatsu H, Munemoto S, Murata R, et al. Anticancer Res. 33(12), 5681-5, (2013)

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Improvement of adherence to guidelines for antiemetic medication enhances emetic control in patients with colorectal cancer receiving chemotherapy of moderate emetic risk. Fujii H, Iihara H, Ishihara M, et al. Anticancer Res. 33(12), 5549-56, (2013)

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Dynamic modulation of thymic microRNAs in response to stress. Serkan Belkaya et al PLoS ONE 6, e27580, (2011)

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Modulation of Human Serotonin Transporter Expression by 5-HTTLPR in Colon Cells. Prasansuklab A, Poovorawan Y, and Tencomnao T Int. J. Mol. Sci. 12(10), 6619-34, (2011)

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Low-dose oral mini-pulse dexamethasone therapy in progressive unstable vitiligo. Kanwar AJ, Mahajan R, and Parsad D J. Cutan. Med. Surg. 17(4), 259-68, (2013)

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MIF attenuates the suppressive effect of dexamethasone on IL-6 production by nasal polyp. Stathas T, Athanassiou SD, Drakouli S, et al. Eur. Rev. Med. Pharmacol. Sci. 17(11), 1455-66, (2013)

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Hypoglycaemic effects of alcoholic root extract of Borassus flabellifer (Linn.) in normal and diabetic rats. Debnath T, Radhakrishnan R, Murugananthan G, et al. Pak. J. Pharm. Sci. 26(4), 673-9, (2013)

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Impaired gonadal function in a woman with multiple symmetric lipomatosis. Rendina D, De Filippo G, Nazzaro A, et al. Minerva Endocrinol. 38(2), 211-5, (2013)

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Effect of intravenous dexamethasone on prevertebral soft tissue swelling after anterior cervical discectomy and fusion. Nam TW, Lee DH, Shin JK, et al. Acta Orthop. Belg. 79(2), 211-5, (2013)

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Early effects of dexamethasone and anti-VEGF therapy in an inflammatory corneal neovascularization model. Mirabelli P, Peebo BB, Xeroudaki M, et al. Exp. Eye Res. 125, 118-27, (2014)

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POEMS syndrome: a challenging diagnosis of a rare disease. Creamer A, Gaastra B, Odogwu S, et al. Br. J. Hosp. Med. (Lond.) 75(7), 408-9, (2014)

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Identification of functional glucocorticoid response elements in the mouse FoxO1 promoter. Qin W, Pan J, Qin Y, et al. Biochem. Biophys. Res. Commun. 450(2), 979-83, (2014)

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Dexamethasone for the prevention of postpericardiotomy syndrome: A DExamethasone for Cardiac Surgery substudy. Bunge JJ, van Osch D, Dieleman JM, et al. Am. Heart J. 168(1), 126-31.e1, (2014)

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Changes in macular function after ozurdex for retinal vein occlusion. Querques G, Cascavilla ML, Cavallero E, et al. Optom. Vis. Sci. 91(7), 760-8, (2014)

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Aprepitant versus dexamethasone for delayed emesis: what is the role of the 5-hydroxytryptamine type 3 receptor antagonist palonosetron? Celio L, de Braud F, and Aapro M J. Clin. Oncol. 32(20), 2185-6, (2014)

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Corticosteroids found ineffective for phosgene-induced acute lung injury in rats. Luo S, Pauluhn J, Trübel H, et al. Toxicol. Lett. 229(1), 85-92, (2014)

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The effects of dexamethasone and metoclopramide on early and late postoperative nausea and vomiting in women undergoing myomectomy under spinal anaesthesia. Tobi KU, Imarengiaye CO, and Amadasun FE Niger. J. Clin. Pract. 17(4), 449-55, (2014)

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Best treatment strategies in high-risk multiple myeloma: navigating a gray area. Bianchi G, Richardson PG, and Anderson KC J. Clin. Oncol. 32(20), 2125-32, (2014)

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Comparison of clinical effects of prilocaine, dexamethasone added to prilocaine and levobupivacaine on brachial plexus block. Saritas A and Sabuncu C J. Pak. Med. Assoc. 64(4), 433-6, (2014)

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Dexamethasone modifies mitomycin C-triggered interleukin-8 secretion in isolated human Tenon's capsule fibroblasts. Ho WT, Chen TC, Chou SF, et al. Exp. Eye Res. 124, 86-92, (2014)

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Acute migraine treatment in emergency settings. Saguil A and Lax JW Am. Fam. Physician 89(9), 742-4, (2014)

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Effect of a proteasome inhibitor plus steroids on HLA antibodies in sensitized patients awaiting a renal transplant. Aubert O, Suberbielle C, Gauthe R, et al. Transplantation 97(9), 946-52, (2014)

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Dexamethasone-loaded poly(D, L-lactic acid) microspheres/poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) micelles composite for skin augmentation. Fan M, Liao J, Guo G, et al. J. Biomed. Nanotechnol. 10(4), 592-602, (2014)

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A new technique of bronchial microsampling and proteomic analysis of epithelial lining fluid in a rat model of acute lung injury. Kamiyama I, Kohno M, Kamiya K, et al. Mol. Immunol. 59(2), 217-25, (2014)

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Dexamethasone produces dose-dependent inhibition of sugammadex reversal in in vitro innervated primary human muscle cells. Rezonja K, Sostaric M, Vidmar G, et al. Anesth. Analg. 118(4), 755-63, (2014)

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P53 dependent mitochondrial permeability transition pore opening is required for dexamethasone-induced death of osteoblasts. Zhen YF, Wang GD, Zhu LQ, et al. J. Cell Physiol. 229(10), 1475-83, (2014)

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Dexamethasone effects on vascular flow and organ injury in septic mice. Aytac HO, Iskit AB, and Sayek I J. Surg. Res. 188(2), 496-502, (2014)

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Clinical outcomes of AIDS-related Burkitt lymphoma: a multi-institution retrospective survey in Japan. Kojima Y, Hagiwara S, Uehira T, et al. Jpn. J. Clin. Oncol. 44(4), 318-23, (2014)

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Does dexamethasone induce more neuropsychological side effects than prednisone in pediatric acute lymphoblastic leukemia? A systematic review. Warris LT, van den Heuvel-Eibrink MM, den Hoed MA, et al. Pediatr. Blood Cancer 61(7), 1313-8, (2014)

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Alpha-lipoic acid attenuates adipocyte differentiation and lipid accumulation in 3T3-L1 cells via AMPK-dependent autophagy. Hahm JR, Noh HS, Ha JH, et al. Life Sci. 100(2), 125-32, (2014)

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Dexamethasone for acute asthma exacerbations in children: a meta-analysis. Keeney GE, Gray MP, Morrison AK, et al. Pediatrics 133(3), 493-9, (2014)

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Porcine glucocorticoid receptor (NR3C1) gene: tissue-specificity of transcriptional strength and glucocorticoid responsiveness of alternative promoters. Jiang Z, Qian L, Zou H, et al. J. Steroid Biochem. Mol. Biol. 141, 87-93, (2014)

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Polymeric delivery systems for dexamethasone. Urbańska J, Karewicz A, and Nowakowska M Life Sci. 96(1-2), 1-6, (2014)

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Does corticosteroid have any beneficial effect on voice change after thyroidectomy? Nasiri S, Shafag S, Khorgami Z, et al. Am. Surg. 79(12), 1258-62, (2013)

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Acute ablation of DP thymocytes induces up-regulation of IL-22 and Foxn1 in TECs. Pan B, Liu J, Zhang Y, et al. Clin. Immunol. 150(1), 101-8, (2014)

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Aprepitant versus dexamethasone for preventing chemotherapy-induced delayed emesis in patients with breast cancer: a randomized double-blind study. Roila F, Ruggeri B, Ballatori E, et al. J. Clin. Oncol. 32(2), 101-6, (2014)

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Dexamethasone for increasing analgesic duration of single-shot inter-scalene block. Fields KG and YaDeau J Br. J. Anaesth. 112(1), 176-7, (2014)

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Intravenous or perineural dexamethasone for interscalene brachial plexus block: the equivalence not yet proven. Sondekoppam RV, Uppal V, and Ganapathy S Br. J. Anaesth. 112(1), 175-6, (2014)

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Is no nausea worth a little insulin? Allen GC Br. J. Anaesth. 112(1), 172, (2014)

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Efficacy of dexamethasone in the prophylaxis of nausea and vomiting during the postoperative period of laparoscopic cholecystectomy. Bernardo WM and Aires FT Rev. Assoc. Med. Bras. 59(4), 387-91, (2013)

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Merck 14,2943

Aldrich MSDS 1, 556:D / Corp MSDS 1 (1), 1039:B / FT-NMR 1 (3), 585:C / RegBook 1 (2), 2863:L / Sax 6, 2493 / Sigma FT-IR 1 (1), 1233:A / Structure Index 1, 458:A:8

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