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D5318 Sigma

DCP-LA

≥95% (HPLC), oil

Synonym: 2-[(2-pentylcyclopropyl)methyl]cyclopropaneoctanoic acid, 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid, FR 236924

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, D-DIF,
InChI Key   CONYTTFKIUJZOF-UHFFFAOYSA-N
assay   ≥95% (HPLC)
form   oil
color   clear
solubility   DMSO: >2 mg/mL
storage temp.   2-8°C

Description

Biochem/physiol Actions

DCP-LA is a selective PKC-epsilon (PKC-ε) activator. In the in situ PKC assay with a reversed phase high-performance liquid chromatography, DCP-LA significantly activated PKC in PC-12 cells in a concentration (10 nM-100 μM)-dependent manner, with the maximal effect at 100 nM. DCP-LA has over a 7-fold greater potency for activation of PKC-ε over other PKC isozymes.

Features and Benefits

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Safety Information

RIDADR 
NONH for all modes of transport
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Documents

Certificate of Analysis

Protocols & Articles

Articles

PKC

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins. It was first identified in 1977 in bovine cerebellum by Nishizuka and co-workers as ...
Keywords: Apoptosis, Atomic absorption spectroscopy, Biological processes, Cancer, Catalysis, Cell signaling, Degradations, Diabetes, Gastrointestinal, Gene expression, Immobilization, Phosphorylations, Pulsed discharge ionization detector, Transcription, Ubiquitinations

Peer-Reviewed Papers
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References

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