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D5566 Sigma

Dolastatin 15

≥95%

Synonym: (5S)-1-[(2S)-O-(N,N-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline

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Properties

Related Categories Antitumor Agents, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix,
InChI Key   LQKSHSFQQRCAFW-CCVNJFHASA-N
assay   ≥95%
storage temp.   −20°C

Description

Amino Acid Sequence

Val-Val-NMe-Val-Pro-Pro-2-hydroxyisovaleryl-2-oxo-4-methoxy-5-benzyl-3-pyrroline

Application

An anti-neoplastic pseudopeptide originally isolated from the sea hare Dolabella auricularia. Reported to interact with tubulin and induce apoptosis. Potent inhibitor of the proliferation of murine and cancer cell lines as well as of hematopoietic progenitor cells.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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