DAPT
≥98% (HPLC), solid
DOWNLOAD MSDS (PDF)Synonym:
LY-374973,
N-
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CAS Number 208255-80-5
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Empirical Formula (Hill Notation) C23H26F2N2O4
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Molecular Weight 432.46
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MDL number MFCD04974585
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PubChem Substance ID 24893987
Properties
| Related Categories | Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, |
| assay | ≥98% (HPLC) |
| form | solid |
| color | white |
| solubility | DMSO: ~18 mg/mL |
| storage temp. | 2-8°C |
| Gene Information |
human ... APH1A(51107), APH1B(83464), NCSTN(23385), NOTCH1(4851), NOTCH2(4853), NOTCH3(4854), NOTCH4(4855), PSEN1(5663), PSEN2(5664), PSENEN(55851) mouse ... Aph1a(226548), Aph1b(208117), Ncstn(59287), Notch1(18128), Notch2(18129), Notch3(18131), Notch4(18132), Psen1(19164), Psen2(19165), Psenen(66340) rat ... Aph1a(365872), Aph1b(300802), Ncstn(289231), Notch1(25496), Notch2(29492), Notch3(56761), Notch4(406162), Psen1(29192), Psen2(81751), Psenen(292788) |
Description
Frequently Asked Questions
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Biochem/physiol Actions
DAPT is a γ-secretase inhibitor and indirectly an inhibitor of Notch, a γ-secretase substrate. As an inhibitor of γ-secretase, DAPT may be useful in the study of β-amyloid (Aβ) formation. As an inhibitor of Notch, DAPT may advance studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus (SLE). Other γ-secretase substrates include LDL receptor-related protein, E-cadherin and ErbB-4.
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