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2′-Deoxyadenosine 5′-triphosphate (dATP) is used as a substrate by a variety of polymerases including DNA polymerase(s) and reverse transcriptase(s).
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100 mM, pH 7
Individual dNTPs for routine PCR; 0.25 mL each
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Adenosine 3':5'-monophosphate (cAMP) modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channel...
Keywords: Catalysis, Cell proliferation, Detergents, Diabetes, Gene expression, Gluconeogenesis, Hormones, Ligands, Neurotransmission, Recombination, Transduction
Once known as P2 purinoreceptors, surface receptors for extracellular nucleotides are now called P2 receptors. This subtle change in nomenclature reflects the more varied nature of nucleotidic ligand...
dNTP-dependent conformational transitions in the fingers subdomain of Klentaq1 DNA polymerase: insights into the role of the "nucleotide-binding" state. Rothwell PJ, Allen WJ, Sisamakis E, et al. J. Biol. Chem. 288(19), 13575-91, (2013)
Differential furanose selection in the active sites of archaeal DNA polymerases probed by fixed-conformation nucleotide analogues. Ketkar A, Zafar MK, Banerjee S, et al. Biochemistry 51(45), 9234-44, (2012)
Pre-steady state kinetic analysis of cyclobutyl derivatives of 2'-deoxyadenosine 5'-triphosphate as inhibitors of HIV-1 reverse transcriptase. Kim J, Wang L, Li Y, et al. Bioorg. Med. Chem. Lett. 22(12), 4064-7, (2012)
Crystal structures of a type-1 ribosome inactivating protein from Momordica balsamina in the bound and unbound states. Kushwaha GS, Pandey N, Sinha M, et al. Biochim. Biophys. Acta 1824(4), 679-91, (2012)
Upregulation of cardiomyocyte ribonucleotide reductase increases intracellular 2 deoxy-ATP, contractility, and relaxation. Korte FS, Dai J, Buckley K, et al. J. Mol. Cell. Cardiol. 51(6), 894-901, (2011)
Highly fluorescent 5-(5,6-dimethoxybenzothiazol-2-yl)-2'-deoxyuridine 5'-triphosphate as an efficient substrate for DNA polymerases. Sato K, Sasaki A, and Matsuda A ChemBioChem. 12(15), 2341-6, (2011)
Cell death regulation during influenza A virus infection by matrix (M1) protein: a model of viral control over the cellular survival pathway. Halder UC, Bagchi P, Chattopadhyay S, et al. Cell Death Dis. 2, e197, (2011)
Polynucleotide phosphorylase exonuclease and polymerase activities on single-stranded DNA ends are modulated by RecN, SsbA and RecA proteins. Cardenas PP, Carzaniga T, Zangrossi S, et al. Nucleic Acids Res. 39(21), 9250-61, (2011)
VS411 reduced immune activation and HIV-1 RNA levels in 28 days: randomized proof-of-concept study for antiviral-hyperactivation limiting therapeutics. Lori F, De Forni D, Katabira E, et al. PLoS ONE 7(10), e47485, (2012)
Binary and ternary binding affinities between exonuclease-deficient Klenow fragment (Kf-exo(-)) and various arylamine DNA lesions characterized by surface plasmon resonance. Vaidyanathan VG, Xu L, and Cho BP Chem. Res. Toxicol. 25(8), 1568-70, (2012)
Importance of the C2, N7, and C8 positions to the mutagenic potential of 8-Oxo-2'-deoxyguanosine with two A family polymerases. Hamm ML, Crowley KA, Ghio M, et al. Biochemistry 50(49), 10713-23, (2011)
Reduced level of ribonucleotide reductase R2 subunits increases dependence on homologous recombination repair of cisplatin-induced DNA damage. Lin ZP, Lee Y, Lin F, et al. Mol. Pharmacol. 80(6), 1000-12, (2011)
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