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D6770 Sigma

Digoxin

analytical standard

Synonym: 12β-Hydroxydigitoxin

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Properties

Related Categories 1694 Pharmaceuticals & Personal Care Products, Additional Standards, Analytical Standards, Analytical/Chromatography, Bioactive Small Molecule Alphabetical Index,
grade   analytical standard
InChI Key   LTMHDMANZUZIPE-PUGKRICDSA-N
form   powder
packaging   vial of 250 mg
suitability   suitable for 1694 per US EPA
Gene Information   human ... ABCB1(5243), CYP3A4(1576)
mouse ... Abcb1a(18671), Abcb1b(18669)
rat ... Atp1a1(24211)

Description

Packaging

1 vial in glass bottle

Supplied in amber screw-cap vials

Biochem/physiol Actions

A cardiac glycoside, substrate for Pgp, upregulates Pgp expression and down regulates SXR (Steroid Xenobiotic Receptor).

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Discover Bioactive Small Molecules for ADME/Tox

A significant number of drugs that fail in clinical trials have been associated with safety issues, including unexpected drug-drug interactions (DDI) or lack of efficacy due to poor pharmacokinetics....
Keywords: Absorption, Bioactive small molecules, Clinical, Metabolism

Peer-Reviewed Papers
15

References

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