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D7137 Sigma

Dihydroxyacetone phosphate dilithium salt

≥93% (enzymatic)

Synonym: 1,3-Dihydroxy-2-propanone 1-phosphate dilithium salt, 1-Hydroxy-3-(phosphonooxy)-2-propanone dilithium salt, DHAP

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Properties

Related Categories Aerobic Glycolysis (the Warburg Effect), Biochemicals and Reagents, Cancer Metabolism, Cancer Research, Carbohydrate,
InChI Key   QWIKESRFRWLYIA-UHFFFAOYSA-L
assay   ≥93% (enzymatic)
impurities   ~0.2 mol % D-glyceraldehyde 3-phosphate
solubility   : soluble50mg plus 1ml of H2O, clear, colorless to faintly yellow
anion traces   phosphate (PO43-): ~5 mol %
storage temp.   −20°C

Description

Caution

Unlike the dimethyl ketal, does not require hydrolysis prior to use as a substrate.

Packaging

10 mg in autosample vial

25 mg in glass bottle

5 mg in glass bottle

100, 250 mg in poly bottle

Preparation Note

Enzymatically prepared.

Application

Dihydroxyacetone phosphate (DHAP) is used in fructose metabolism, triose and glycation research. It is used in studies involving the metabolism of three-carbon sugar pools and their roles in physiological and physical processes. DHAP may be used as a substrate to help identify, differentiate and characterize fructose-bisphosphate aldolase(s) (ALDOA) and triosephosphate isomerase(s). DHAP may be used to study cellular glycation stress.

Biochem/physiol Actions

Dihydroxyacetone phosphate (DHAP) is a metabolic intermediate involved in many pathways, including glycolysis, gluconeogenesis, glycerol metabolism, phosphatidic acid synthesis, fat metabolism, and the Calvin cycle.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. D7137.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Aerobic Glycolysis and the Warburg Effect

The Warburg effect is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer ce...
Keywords: Aerobic, Biofiles, Cancer, Cell proliferation, Clinical, Glycolysis, PAGE, Phosphorylations, Support, Transcription

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Monosaccharide Biosynthesis

Each of the monosaccharides has its own interesting metabolism. The pathway by which a monosaccharide is made, is not the reverse of its degradation pathway (see Figure 4).
BioFiles 2007, 2.6, 21.
Keywords: Addition reactions, Biofiles, Carboxylations, Catalysis, Condensations, Decarboxylations, Degradations, Metabolic Pathways, Metabolism, Metabolites, Phosphorylations, Reductions

Peer-Reviewed Papers
15

References

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