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D7385 Sigma

Demecolcine

≥98% (HPLC)

Synonym: N-Deacetyl-N-methylcolchicine

  • CAS Number 477-30-5

  • Empirical Formula (Hill Notation) C21H25NO5

  • Molecular Weight 371.43

  •  Beilstein Registry Number 2822892

  •  EC Number 207-514-6

  •  MDL number MFCD00075459

  •  PubChem Substance ID 24894128

  • Popular Documents:  FTNMR (PDF)  

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Properties

Related Categories Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, Inhibitors,
InChI Key   NNJPGOLRFBJNIW-HNNXBMFYSA-N
assay   ≥98% (HPLC)
form   powder
solubility   chloroform: soluble10 mg/mL
  ethanol: soluble
storage temp.   2-8°C

Description

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Application

Demecolcine has been used as a microtubule depolymerizing agent. It has also been used to inhibit mitotic division.

Biochem/physiol Actions

Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.

Price and Availability


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Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3
RTECS 
GH0800000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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