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D7662 Sigma

Delorazepam

Synonym: 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one

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Properties

form   neat
drug control   USDEA Schedule IV; Home Office Schedule 4.1; psychotrope; kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada
format   neat

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Safety Information

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GHS07  GHS07
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Warning
Hazard statements 
Personal Protective Equipment 
WGK Germany 
3
RTECS 
DF2367500

Documents

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Protocols & Articles

Peer-Reviewed Papers

References

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Paroxetine efficacy in the treatment of generalized anxiety disorder. Rocca P, Fonzo V, Scotta M, et al. Acta Psychiatr. Scand. 95(5), 444-50, (1997)

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Peripheral benzodiazepine receptor messenger RNA is decreased in lymphocytes of generalized anxiety disorder patients. Rocca P, Beoni AM, Eva C, et al. Biol. Psychiatry 43(10), 767-73, (1998)

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Premedication with chlordemethyldiazepam and anxiolytic effect of diazepeam in implantology. Manani G, Baldinelli L, Cordioli G, et al. Anesth. Prog. 42(3-4), 107-12, (1995)

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[Preanesthesia in elderly patients undergoing subarachnoid anesthesia: chlordesmethyldiazepam versus diazepam]. Ramella G, Costagli V, Sogni A, et al. Minerva Anestesiol. 60(4), 181-4, (1994)

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[Use of a chlordemethyldiazepam-fentanyl combination in invasive neuroradiologic examinations]. Scafuro M, Ciritella P, Di Gregorio AM, et al. Minerva Anestesiol. 54(9), 363-6, (1988)

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[A ketamine-chlordemethyldiazepam combination in celioscopy]. Struzziero E, Corbo M, and Zeppa G Minerva Ginecol. 40(12), 715-7, (1988)

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[Chlordesmethyldiazepam and prolactinemia during surgical stress]. D'Eramo C, Tirelli F, and Maestri D Acta Biomed. 60(5-6), 217-22, (1989)

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[Control of the side effects of ketamine: chlordemethyldiazepam vs diazepam in pre-anesthesia]. D'Eramo C, Stocchetti N, Iacovelli W, et al. Minerva Anestesiol. 55(10), 413-7, (1989)

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Comparison by means of bispectral index score, between anxiolysis induced by diazepam and sedation induced by midazolam. Manani G, Facco E, Favero L, et al. Minerva Stomatol. 60(7-8), 365-81, (2011)

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[Antagonism with flumazenil of sedation by benzodiazepine during loco-regional anesthesia]. Campisi M, Iseppi D, Stacca R, et al. Minerva Anestesiol. 56(9), 913-5, (1990)

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Combined sedation with oral chlordemethyldiazepam and midazolam by nasal route in third molar surgery. Manani G, Bazzato MF, Boscolo I, et al. Minerva Stomatol. 53(5), 241-50, (2004)

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Abnormal ventricular repolarization mimicking myocardial infarction after heterocyclic antidepressant overdose. Bolognesi R, Tsialtas D, Vasini P, et al. Am. J. Cardiol. 79(2), 242-5, (1997)

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Reduction of temazepam to diazepam and lorazepam to delorazepam during enzymatic hydrolysis. Fu S, Molnar A, Bowron P, et al. Anal. Bioanal. Chem 400(1), 153-64, (2011)

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Determination of delorazepam in urine by solid-phase microextraction coupled to high performance liquid chromatography. Aresta A, Monaci L, and Zambonin CG J. Pharm. Biomed. Anal. 28(5), 965-72, (2002)

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Double-blind placebo cross-over study of long-acting (chlordesmethyldiazepam) versus short-acting (lorazepam) benzodiazepines in generalized anxiety disorders. Bertin I, Colombo G, Furlanut M, et al. Int. J. Clin. Pharmacol. Res. 9(3), 203-8, (1989)

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Effects of liver disease on the pharmacokinetics of intravenous and oral chlordesmethyldiazepam. Bareggi SR, Pirola R, Potvin P, et al. Eur. J. Clin. Pharmacol. 48(3-4), 265-8, (1995)

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SPME-LC with UV detection to study delorazepam-serum albumin interactions. Zambonin CG and Aresta A J. Pharm. Biomed. Anal. 29(5), 895-900, (2002)

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Pharmacokinetics of intravenous and oral chlordesmethyldiazepam in patients on regular haemodialysis. Sennesael J, Verbeelen D, Vanhaelst L, et al. Eur. J. Clin. Pharmacol. 41(1), 65-8, (1991)

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Effect of chronic oral delorazepam on in vitro and in vivo hepatic drug-metabolizing enzyme activities in the rat. Conti I, Tridico RV, and Caccia S Res. Commun. Chem. Pathol. Pharmacol. 67(1), 87-99, (1990)

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Niaprazine vs chlordesmethyldiazepam in sleep disturbances in pediatric outpatients. Montanari G, Schiaulini P, Covre A, et al. Pharmacol. Res. 25 Suppl 1, 83-4, (1992)

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Binding of [3H]CB 34, a selective ligand for peripheral benzodiazepine receptors, to rat brain membranes. Pisu, M.G. et al. Eur. J. Pharmacol. 432, 129-134, (2001)

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Quantification of chlordesmethyldiazepam by liquid chromatography-tandem mass spectrometry: application to a cloxazolam bioequivalence study. Oliveira-Silva D, Oliveira CH, Mendes GD, et al. Biomed. Chromatogr. 23(12), 1266-75, (2009)

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Combined occlusal and pharmacological therapy in the treatment of temporo-mandibular disorders. Inchingolo F, Tatullo M, Marrelli M, et al. Eur. Rev. Med. Pharmacol. Sci. 15(11), 1296-300, (2011)

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Depressive stupor and chlordesmethyldiazepam. Benazzi F Can. J. Psychiatry. 35(8), 722, (1990)

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Depressive stupor treated with intramuscular chlordesmethyldiazepam. Benazzi F Can. J. Psychiatry. 35(3), 282, (1990)

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