D7693 Sigma

Dynasore hydrate

Synonym: 3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide hydrate

  • CAS Number 1202867-00-2

  • Empirical Formula (Hill Notation) C18H14N2O4 · xH2O

  • Molecular Weight 322.31 (anhydrous basis)

  •  MDL number MFCD11045288


Related Categories Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DIG-DY, G Protein Function,
form   powder
storage condition   protect from light
color   off-white
solubility   DMSO: ≥10 mg/mL
  H2O: insoluble
storage temp.   −20°C


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Biochem/physiol Actions

Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.

General description

Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.

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