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D7693 Sigma

Dynasore hydrate

Synonym: 3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide hydrate

  • CAS Number 1202867-00-2

  • Empirical Formula (Hill Notation) C18H14N2O4 · xH2O

  • Molecular Weight 322.31 (anhydrous basis)

  •  MDL number MFCD11045288

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DIG-DY,
form   powder
storage condition   protect from light
color   off-white
solubility   DMSO: ≥10 mg/mL
  H2O: insoluble
storage temp.   −20°C

Description

Frequently Asked Questions

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Biochem/physiol Actions

Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.

General description

Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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DISCOVER Bioactive Small Molecules

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Safety & Documentation

Safety Information

Symbol 
GHS09  GHS09
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3

Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cyclic Nucleotides

Transmission of an extracellular signal across the cell membrane is initiated by activation of many types of hormone and neurotransmitter receptors, such as G-protein coupled receptors (GPCRs), and c...
Keywords: Antivirals, Cancer, Cardiovascular, Cellular processes, Diabetes, Diseases, Hormones, Neurotransmitters

Peer-Reviewed Papers

References

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Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis Kirchhausen T, et al. Meth. Enzymol. 438, 77-93, (2008)

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Dynasore, a cell-permeable inhibitor of dynamin. Macia, E., et al. Dev. Cell 10, 839-850, (2006)

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Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis. Newton, A.J., et al. Proc. Natl. Acad. Sci. U. S. A. 103, 17955-17960, (2006)

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Internalization of Coxsackievirus A9 Is Mediated by {beta}2-Microglobulin, Dynamin, and Arf6 but Not by Caveolin-1 or Clathrin Heikkila, O., et al. J. Virol. 84, 3666-81, (2010)

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Dynasore- a Dynamin Inhibitor, Induces PAI-1 Expression in MeT-5A Human Pleural Mesothelial Cells Chung CL, et al. Am. J. Respir. Cell. Mol. Biol. Oct 31., 92-700, (2008)

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Dynasore puts a new spin on dynamin: a surprising dual role during vesicle formation. Nakoe, S.R., and Sever, S. Trends Cell Biol. 16, 607-609, (2006)

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HPV16 and BPV1 infection can be blocked by the dynamin inhibitor dynasore Abban CY, et al. Am. J. Ther. 15, 304-311, (2008)

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Discovery of a new 'dynasore'. Thompson, H.M., and McNiven, M.A. Nat. Chem. Biol. 2, 355-356, (2006)

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Treatment intensification with stepwise addition of prandial insulin aspart boluses compared with full basal-bolus therapy (FullSTEP Study): a randomised, treat-to-target clinical trial. Rodbard HW, Visco VE, Andersen H, et al. Lancet. Diabetes Endocrinol. 2(1), 30-7, (2014)

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Midlife type 2 diabetes and poor glycaemic control as risk factors for cognitive decline in early old age: a post-hoc analysis of the Whitehall II cohort study. Tuligenga RH, Dugravot A, Tabák AG, et al. Lancet. Diabetes Endocrinol. 2(3), 228-35, (2014)

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Low-dose calcium supplementation for preventing pre-eclampsia: a systematic review and commentary. Hofmeyr G, Belizán J, and von Dadelszen P BJOG, doi:10.1111/1471-0528.12613, (2014)

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Uterine adenomyosis and in vitro fertilization outcome: a systematic review and meta-analysis. Vercellini P, Consonni D, Dridi D, et al. Hum. Reprod., (2014)

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Prophylaxis with levofloxacin: impact on bacterial susceptibility and epidemiology in a hematopoietic stem cell transplant unit. Lopes LA, Veroneze I, Burgardt CI, et al. Rev. Bras. Hematol. Hemoter. 36(1), 35-42, (2014)

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The off-pump technique in redo coronary artery bypass grafting reduces mortality and major morbidities: propensity score analysis of data from the Japan Cardiovascular Surgery Database. Dohi M, Miyata H, Doi K, et al. Eur. J. Cardiothorac. Surg., (2014)

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Prognostic Value of the Physical Examination in Patients With Heart Failure and Atrial Fibrillation: Insights From the AF-CHF Trial (Atrial Fibrillation and Chronic Heart Failure). Caldentey G, Khairy P, Roy D, et al. JACC Heart Fail. 2(1), 15-23, (2014)

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The STICH Trial (Surgical Treatment for Ischemic Heart Failure): Mode-of-Death Results. Carson P, Wertheimer J, Miller A, et al. JACC Heart Fail. 1(5), 400-8, (2013)

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[Effect of Aloe emodin on invasion and metastasis of high metastatic breast cancer MDA-MB-231 cells]. He ZH, Huang YQ, Weng SF, et al. Zhong Yao Cai 36(9), 1481-5, (2013)

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Epithelial Remodeling After Femtosecond Laser-assisted High Myopic LASIK: Comparison of Stand-alone With LASIK Combined With Prophylactic High-fluence Cross-linking. Kanellopoulos AJ and Asimellis G Cornea, (2014)

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Efficacy and safety of moxifloxacin in acute exacerbations of chronic bronchitis and COPD: a systematic review and meta-analysis. Liu KX, Xu B, Wang J, et al. J. Thorac. Dis. 6(3), 221-9, (2014)

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Renal dysfunction in stroke patients: A hospital-based cohort study and systematic review. Rowat A, Graham C, and Dennis M Int. J. Stroke, doi:10.1111/ijs.12264, (2014)

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Clinical Characteristics and Outcome of 467 Patients With a Clinically Recognized Eating Disorder Identified Among 52,215 Patients With Type 1 Diabetes Mellitus: A Multicenter German/Austrian Study. Scheuing N, Bartus B, Berger G, et al. Diabetes Care, (2014)

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Hip fractures and bone mineral density in the elderly-importance of serum 25-hydroxyvitamin d. Steingrimsdottir L, Halldorsson TI, Siggeirsdottir K, et al. PLoS ONE 9(3), e91122, (2014)

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Computerized Image Analysis for Identifying Triple-Negative Breast Cancers and Differentiating Them from Other Molecular Subtypes of Breast Cancer on Dynamic Contrast-enhanced MR Images: A Feasibility Study. Agner SC, Rosen MA, Englander S, et al. Radiology, 121031, (2014)

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Correlates of Incident Trichomonas vaginalis Infections Among African American Female Adolescents. Swartzendruber A, Sales JM, Brown JL, et al. Sex. Transm. Dis. 41(4), 240-5, (2014)

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Myosin Vb mediated plasma membrane homeostasis regulates peridermal cell size and maintains tissue homeostasis in the zebrafish epidermis. Sonal, Sidhaye J, Phatak M, et al. PLoS Genet. 10(9), e1004614, (2014)

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Islet Size Index as a Predictor of Outcomes in Clinical Islet Autotransplantation. Suszynski TM, Wilhelm JJ, Radosevich DM, et al. Transplantation, (2014)

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The predictive role of pretreatment epidermal growth factor receptor T790M mutation on the progression-free survival of tyrosine-kinase inhibitor-treated non-small cell lung cancer patients: a meta-analysis. Ding D, Yu Y, Li Z, et al. Onco. Targets Ther. 7, 387-393, (2014)

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Local Activation of Uterine Toll-Like Receptor 2 and 2/6 Decreases Embryo Implantation and Affects Uterine Receptivity in Mice. Sanchez-Lopez JA, Caballero I, Montazeri M, et al. Biol. Reprod., (2014)

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Is an annular tear a predictor for accelerated disc degeneration? Farshad-Amacker NA, Hughes AP, Aichmair A, et al. Eur. Spine J., (2014)

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Three-dimensional analysis of the left atrial appendage for detecting paroxysmal atrial fibrillation in acute ischemic stroke. Tanaka K, Koga M, Sato K, et al. Int. J. Stroke, doi:10.1111/ijs.12268, (2014)

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Reaction Monitoring Using Mid-Infrared Laser-Based Vibrational Circular Dichroism. Rüther A, Pfeifer M, Lórenz-Fonfría VA, et al. Chirality, doi:10.1002/chir.22307, (2014)

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Hollow-fiber-supported liquid-phase microextraction using an ionic liquid as the extractant for the pre-concentration of bisphenol A, 17-β-estradiol, estrone and diethylstilbestrol from water samples with HPLC detection. Zou Y, Zhang Z, Shao X, et al. Water Sci. Technol. 69(5), 1028-35, (2014)

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Clinical study of treatment switching from premixed insulin to basal insulin combined with oral hypoglycemic drugs in patients with type 2 diabetes. Zhang Y, Xie YJ, Meng DD, et al. Diabetol. Metab. Syndr. 6(1), 37, (2014)

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Comparison of acellular pertussis-tetanus-diphtheria vaccines and whole-cell pertussis-tetanus-diphtheria vaccines in infancy. Korkmaz HA, Aydin A, and Unal B Paediatr. Int. Child Health, 2046905513Y0000000110, (2013)

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