|Related Categories||Biochemicals and Reagents, Cofactors, Enzymes, Inhibitors, and Substrates, Oxidation-Reduction|
PQQ is present in nanomolar quantities in most foods and in most animal tissuse. It promotes growth, mitochondrial function, and development in vivo and stimulates cell proliferation and viability in culture. It is a potent antioxidant that scavenges superoxide and peroxinitrite. It is neuroprotectant against 6-hydroxydopamine-induced and hypoxia/ischemia-induced neurotoxicity. PQQ conjugates to α-synuclein in vitro, inhibiting the formation of amyloid fibrils.
Novel o-quinone coenzyme found in bacterial dehydrogenases and oxidases.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. D7783.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Pyrroloquinoline quinone, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves impaired glucose tolerance in diabetic KK-A(y) mice. Takada M, Sumi M, Maeda A, et al. Biochem. Biophys. Res. Commun. 428(2), 315-20, (2012)
Pyrroloquinoline quinone stimulates epithelial cell proliferation by activating epidermal growth factor receptor through redox cycling. Kimura K, Takada M, Ishii T, et al. Free Radic. Biol. Med. 53(6), 1239-51, (2012)
Coupling of pyrroloquinoline quinone dependent glucose dehydrogenase to (cytochrome c/DNA)-multilayer systems on electrodes. Wettstein Ch, Möhwald H, and Lisdat F Bioelectrochemistry 88, 97-102, (2012)
High-temperature sorbose fermentation with thermotolerant Gluconobacter frateurii CHM43 and its mutant strain adapted to higher temperature. Hattori H, Yakushi T, Matsutani M, et al. Appl. Microbiol. Biotechnol. 95(6), 1531-40, (2012)
Pyrroloquinoline quinone modulates the kinetic parameters of the mammalian selenoprotein thioredoxin reductase 1 and is an inhibitor of glutathione reductase. Xu J and Arnér ES Biochem. Pharmacol. 83(6), 815-20, (2012)
Inhibition of receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation by pyrroloquinoline quinine (PQQ). Odkhuu E, Koide N, Haque A, et al. Immunol. Lett. 142(1-2), 34-40, (2012)
The active (ADHa) and inactive (ADHi) forms of the PQQ-alcohol dehydrogenase from Gluconacetobacter diazotrophicus differ in their respective oligomeric structures and redox state of their corresponding prosthetic groups. Gómez-Manzo S, González-Valdez AA, Oria-Hernández J, et al. FEMS Microbiol. Lett. 328(2), 106-13, (2012)
The neuroprotective action of pyrroloquinoline quinone against glutamate-induced apoptosis in hippocampal neurons is mediated through the activation of PI3K/Akt pathway. Zhang Q, Shen M, Ding M, et al. Toxicol. Appl. Pharmacol. 252, 62-72, (2011)
Identification of Pantoea ananatis gene encoding membrane pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase and pqqABCDEF operon essential for PQQ biosynthesis. Andreeva IG, Golubeva LI, Kuvaeva TM, et al. FEMS Microbiol. Lett. 318(1), 55-60, (2011)
Absorbance-based assay for membrane disruption by antimicrobial peptides and synthetic copolymers using pyrroloquinoline quinone-loaded liposomes. Zimmerman LB, Worley BV, et al. Anal. Biochem. 411, 194-199, (2011)
Characterization of a protein-generated O₂ binding pocket in PqqC, a cofactorless oxidase catalyzing the final step in PQQ production. RoseFigura JM, Puehringer S, Schwarzenbacher R, et al. Biochemistry 50(9), 1556-66, (2011)
Pyrroloquinoline quinone rescues hippocampal neurons from glutamate-induced cell death through activation of Nrf2 and up-regulation of antioxidant genes. Zhang Q, Ding M, Gao XR, et al. Genet. Mol. Res. 11(3), 2652-64, (2012)
Kinetic study of the quenching reaction of singlet oxygen by Pyrroloquinolinequinol (PQQH(2), a reduced form of Pyrroloquinolinequinone) in micellar solution. Mukai K, Ouchi A, and Nakano M J. Agric. Food Chem. 59(5), 1705-12, (2011)
Simple and Sensitive Method for Pyrroloquinoline Quinone (PQQ) Analysis in Various Foods Using Liquid Chromatography/Electrospray-Ionization Tandem Mass Spectrometry. Noji, N., et al. J. Agric. Food Chem. 55, 7258-7263, (2007)
A novel molecular marker for studying phylogeny and diversity of phosphate-solubilizing pseudomonads: the pyrroloquinoline quinone biosynthetic gene pqqC. Meyer JB, Frapolli M, Keel C, et al. Appl. Environ. Microbiol. 77(20), 7345-54, (2011)
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