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D7783 Sigma

Pyrroloquinoline quinone

~98% (HPLC)

Synonym: 4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, Methoxatin, PQQ

  • CAS Number 72909-34-3

  • Empirical Formula (Hill Notation) C14H6N2O8

  • Molecular Weight 330.21

  •  Beilstein Registry Number 3596812

  •  MDL number MFCD00043125

  •  PubChem Substance ID 24894162


Related Categories Biochemicals and Reagents, Cofactors, Enzymes, Inhibitors, and Substrates, Oxidation-Reduction
assay   ~98% (HPLC)
storage temp.   2-8°C


Biochem/physiol Actions

PQQ is present in nanomolar quantities in most foods and in most animal tissuse. It promotes growth, mitochondrial function, and development in vivo and stimulates cell proliferation and viability in culture. It is a potent antioxidant that scavenges superoxide and peroxinitrite. It is neuroprotectant against 6-hydroxydopamine-induced and hypoxia/ischemia-induced neurotoxicity. PQQ conjugates to α-synuclein in vitro, inhibiting the formation of amyloid fibrils.

General description

Novel o-quinone coenzyme found in bacterial dehydrogenases and oxidases.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. D7783.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

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