|Related Categories||Apoptosis and Cell Cycle, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology,|
|solubility||DMSO: soluble10 mg/mL|
human ... ESR1(2099), ESR2(2100), UGT1A4(54657)|
mouse ... Aldh1a2(19378), Hexa(15211), Maoa(17161)
rat ... Aldh1a2(116676)
Daidzein is a phytoestrogen that is suggested to play a role in preventing hormone-induced cancers.2 Arrests cell cycle at G1 in Swiss 3T3 cells.3
Soy isoflavone daidzein protects against oxidative damage in liver cells induced by 7,12-dimethylbenz[a]anthr
Packaged under Argon.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xi|
|Risk Statements (Europe)||36/38|
|Safety Statements (Europe)||24-26|
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
BioFiles 2007, 2.2, 2.
Keywords: Adhesion, Anti-inflammatory agents, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins
While reuptake of catecholamines plays an important role in regulating their synaptic levels, metabolism also contributes significantly to the termination of catecholamine neurotransmission. The rela...
Keywords: Atomic layer deposition, Clinical, Dopamine agents, Metabolism, Metabolites, Neurotransmission, Parkinson Disease
Serotonin (5-hydroxytryptamine) is principally found stored in three main cell types - i) serotonergic neurons in the CNS and in the intestinal myenteric plexus, ii) enterochromaffin cells in the muc...
Keywords: Anti-depressants, Catalysis, Clinical, Decarboxylations, Dopamine agents, Gastrointestinal, Hormones, Metabolism, Metabolites, Oxidations
ADP- and thapsigargin-evoked Ca2+ entry and protein-tyrosine phosphorylation are inhibited by the tyrosine kinase inhibitors genistein and methyl-25-dihydroxycinnamate in fura-2-loaded human platelets. Sargeant, P., et al. J. Biol. Chem. 268, 18151-18156, (1993)
Secretion of cortisol and aldosterone as a vulnerable target for adrenal endocrine disruption - screening of 30 selected chemicals in the human H295R cell model. Ullerås, E., et al. J. Appl. Toxicol. 28, 1045-53, (2008)
Inhibition of Cell Proliferation and MAP Kinase and Akt Pathways in Oral Squamous cell Carcinoma by Genistein and Biochanin A Johnson, T.L., et al. Evid. Based. Complement. Alternat. Med. 7, 351, (2010)
Enterorhabdus caecimuris sp. nov., a member of the family Coriobacteriaceae isolated from a mouse model of spontaneous colitis, and emended description of the genus Enterorhabdus Clavel et al. 2009 Clavel, T., et al. Int. J. Syst. Evol. Microbiol. 60, 1527-31, (2010)
Modulatory effects of phytoestrogens on the expression of Fas ligand and the release of cytochrome C in normal and cancerous endometrial cells. Poonyachoti S and Deachapunya C J. Med. Assoc. Thai. 95 Suppl 12, S105-12, (2012)
Rivaroxaban, a direct inhibitor of the coagulation factor Xa interferes with hormonal-induced physiological modulations in human female osteoblastic cell line SaSO2. Somjen D, Katzburg S, Gigi R, et al. J. Steroid Biochem. Mol. Biol. 135, 67-70, (2013)
Mechanisms underlying the dualistic mode of action of major soy isoflavones in relation to cell proliferation and cancer risks. Rietjens IM, Sotoca AM, Vervoort J, et al. Mol. Nutr. Food. Res. 57(1), 100-13, (2013)
Androgen deprivation by flutamide modulates uPAR, MMP-9 expressions, lipid profile, and oxidative stress: amelioration by daidzein. Lateef A, Khan AQ, Tahir M, et al. Mol. Cell Biochem. 374(1-2), 49-59, (2013)
[Microbial conversion of daidzein affects fecal equol concentration and bacterial composition of rats with or without ovariectomy]. Zhang X, Zheng W, Huang S, et al. Wei Sheng Wu Xue Bao 52(7), 866-74, (2012)
Genistein and daidzein, typical soy isoflavones, inhibit TNF-α-mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes. Yanagisawa M, Sugiya M, Iijima H, et al. Mol. Nutr. Food. Res. 56(12), 1783-93, (2012)
The soy isoflavone equol may increase cancer malignancy via up-regulation of eukaryotic protein synthesis initiation factor eIF4G. de la Parra C, Otero-Franqui E, Martinez-Montemayor M, et al. J. Biol. Chem. 287(50), 41640-50, (2012)
Interaction effects between genes involved in the AKT signaling pathway and phytoestrogens in gastric carcinogenesis: a nested case-control study from the Korean Multi-Center Cancer Cohort. Yang JJ, Cho LY, Ko KP, et al. Mol. Nutr. Food. Res. 56(11), 1617-26, (2012)
Analysis of daidzein in nanoparticles after oral co-administration with sodium caprate to rats by ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry. Ma Y, Zhang L, Zhao X, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 907, 21-6, (2012)
Estrogen receptor-mediated effects of isoflavone supplementation were not observed in whole-genome gene expression profiles of peripheral blood mononuclear cells in postmenopausal, equol-producing women. van der Velpen V, Geelen A, Schouten EG, et al. J. Nutr. 143(6), 774-80, (2013)
Soy protein, genistein, and daidzein improve serum paraoxonase activity and lipid profiles in rheumatoid arthritis in rats. Mohammadshahi M, Haidari F, Saei AA, et al. J. Med. Food 16(2), 147-54, (2013)
Simultaneous monitoring of seven phenolic metabolites of endocrine disrupting compounds (EDC) in human urine using gas chromatography with tandem mass spectrometry. Schmidt L, Müller J, and Göen T Anal. Bioanal. Chem 405(6), 2019-29, (2013)
Isoformononetin, a methoxydaidzein present in medicinal plants, reverses bone loss in osteopenic rats and exerts bone anabolic action by preventing osteoblast apoptosis. Srivastava K, Tyagi AM, Khan K, et al. Phytomedicine 20(6), 470-80, (2013)
Safety evaluation of daidzein in laying hens: part I. Effects on laying performance, clinical blood parameters, and organs development. Shi SR, Gu H, Chang LL, et al. Food Chem. Toxicol. 55, 684-8, (2013)
Effects of perinatal daidzein exposure on subsequent behavior and central estrogen receptor α expression in the adult male mouse. Yu C, Tai F, Zeng S, et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 43, 157-67, (2013)
Pharmacokinetics of the soybean isoflavone daidzein in its aglycone and glucoside form: a randomized, double-blind, crossover study. Rüfer CE, Bub A, Möseneder J, et al. Am. J. Clin. Nutr. 87(5), 1314-23, (2008)
A urinary profile study of dietary phytoestrogens. The identification and mode of metabolism of new isoflavonoids. Joannou GE, Kelly GE, Reeder AY, et al. J. Steroid Biochem. Mol. Biol. 54(3-4), 167-84, (1995)
Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora. Rowland IR, Wiseman H, Sanders TA, et al. Nutr. Cancer 36(1), 27-32, (2000)
Identification of isoflavone metabolites dihydrodaidzein, dihydrogenistein, 6'-OH-O-dma, and cis-4-OH-equol in human urine by gas chromatography-mass spectroscopy using authentic reference compounds. Heinonen S, Wähälä K, and Adlercreutz H Anal. Biochem. 274(2), 211-9, (1999)
Identification of urinary metabolites of the red clover isoflavones formononetin and biochanin A in human subjects. Heinonen SM, Wähälä K, and Adlercreutz H J. Agric. Food Chem. 52(22), 6802-9, (2004)
Simultaneous determination of daidzein, equol, genistein and bisphenol A in human urine by a fast and simple method using SPE and GC-MS. Moors S, Blaszkewicz M, Bolt HM, et al. Mol. Nutr. Food. Res. 51(7), 787-98, (2007)
Quantitative determination of acetyl glucoside isoflavones and their metabolites in human urine using combined liquid chromatography-mass spectrometry. Chen L, Zhao X, Fang L, et al. J. Chromatogr. A 1154(1-2), 103-10, (2007)
Studies of the in vitro intestinal metabolism of isoflavones aid in the identification of their urinary metabolites. Heinonen SM, Wähälä K, Liukkonen KH, et al. J. Agric. Food Chem. 52(9), 2640-6, (2004)
Metabolism of the soy isoflavones daidzein, genistein and glycitein in human subjects. Identification of new metabolites having an intact isoflavonoid skeleton. Heinonen SM, Hoikkala A, Wähälä K, et al. J. Steroid Biochem. Mol. Biol. 87(4-5), 285-99, (2003)
A transcript profiling approach reveals an epicatechin-specific glucosyltransferase expressed in the seed coat of Medicago truncatula. Yongzhen Pang et al Proc. Natl. Acad. Sci. U. S. A. 105, 14210-5, (2008)
Structure-based virtual screening for plant-based ERbeta-selective ligands as potential preventative therapy against age-related neurodegenerative diseases. Liqin Zhao et al J. Med. Chem. 48, 3463-6, (2005)
Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition. Suresh Awale et al Bioorg. Med. Chem. 16, 181-9, (2008)
Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,). George R Pettit et al J. Nat. Prod. 71, 438-44, (2008)
7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists. Azadeh Matin et al J. Med. Chem. 52, 6835-50, (2009)
Natural ortho-dihydroxyisoflavone derivatives from aged Korean fermented soybean paste as potent tyrosinase and melanin formation inhibitors. Jun-Seong Park et al Bioorg. Med. Chem. Lett. 20, 1162-4, (2010)
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