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D8013 Sigma

P1,P5-Di(adenosine-5′) pentaphosphate ammonium salt

≥95% (HPLC), powder

Synonym: A(5′)P5(5′)A, Diadenosine pentaphosphate ammonium salt

  • Empirical Formula (Hill Notation) C20H29N10O22P5 · xNH3

  • Molecular Weight 916.37 (free acid basis)

  •  PubChem Substance ID 24894177

  •  eCl@ss 32160414

  • Popular Documents:  Specification Sheet (PDF)  

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates, Substrate Analogs More...
assay   ≥95% (HPLC)
form   powder
color   white to off-white
solubility   H2O: soluble50 mg/mL
storage temp.   −20°C

Description

Packaging

10, 25, 50 mg in poly bottle

Biochem/physiol Actions

A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5′-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In heart, it increases contractile force and action potential duration, and shows an anti-β-adrenergic effect.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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