2-Deoxy-D-glucose ≥98% (GC), crystalline

Properties

Related Categories	Aerobic Glycolysis (the Warburg Effect), Biochemicals and Reagents, Cancer Metabolism, Cancer Research, Carbohydrate Library, Carbohydrates, Carbohydrates A to Z, Carbohydrates D-F, Glycobiology, Hexokinase Inhibitors, Inhibitors, Inhibitors and Substrates, Inhibitors of Aerobic Glycolysis (the Warburg Effect), Metabolic Libraries, Metabolomics, Monosaccharide, Post-Translational Modification, Proteomics More...
assay	≥98% (GC)
form	crystalline
color	white to off-white
mp	146-147 °C(lit.)
solubility	Do you have solubility information on this product that you would like to share?

Description

Application

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2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.

Packaging

10 mg in autosample vial

Biochem/physiol Actions

2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.¹

Price and Availability

Related Papers

1. 2-Deoxy-D-glucose treatment of endothelial cells induces autophagy by reactive oxygen species-mediated activation of the AMP-activated protein kinase. Wang, Q. et al. PLoS ONE 6, e17234, (2011)

Documents

Certificate of Analysis

Certificate of Origin

FT-IR Raman

FT-NMR

Safety Information

Personal Protective Equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany	3

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Articles

Aerobic Glycolysis and the Warburg Effect

The Warburg effect is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer ce...
Keywords: Aerobic, Cancer, Cell proliferation, Clinical, Glycolysis, PAGE, Phosphorylations, Transcription

Papers

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1. 2-Deoxy-D-glucose treatment of endothelial cells induces autophagy by reactive oxygen species-mediated activation of the AMP-activated protein kinase. Wang, Q. et al. PLoS ONE 6, e17234, (2011)

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Cytotoxicity, radiosensitization, and chemosensitization of tumor cells by 2-deoxy-D-glucosein vitro. Dwarakanath BS. J. Cancer Res. Ther. 5, S27-31, (2009)

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Protection of normal cells and tissues during radio- and chemosensitization of tumors by 2-deoxy-D-glucose. Farooque A, Afrin F, Adhikari JS, Dwarakanath BS. J. Cancer Res. Ther. 5, S32-35, (2009)

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Modulation of cellular radiation responses by 2-deoxy-D-glucose and other glycolytic inhibitors: implications for cancer therapy. Kalia VK, Prabhakara S, Narayanan V. J. Cancer Res. Ther. 5, S57-60, (2009)

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A combination of 2-deoxy-D-glucose and 6-aminonicotinamide induces oxidative stress mediated selective radiosensitization of malignant cells via mitochondrial dysfunction. Bhardwaj R, Sharma PK, Jadon SS, Varshney R. Tumour Biol. 32, 951-964, (2011)

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Murine Glut-1 transporter haploinsufficiency: postnatal deceleration of brain weight and reactive astrocytosis. Paivi M. Ullner et al Neurobiol. Dis. 36, 60-9, (2009)

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Merck 14,2904

Beil. 1,IV,4282

FT-IR 2 (1), 276:B / FT-IR 1 (1), 192:D / FT-NMR 1 (1), 296:B / IR-Spectra (2), 108:B / IR-Spectra (3), 116:F / NMR-Reference 2 (2), 909:B / RegBook 1 (1), 191:G / Sax 6, 867 / Sigma FT-IR 1 (1), 1054:B / Structure Index 1, 26:D:1