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2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
10 mg in autosample vial
Bottomless glass bottle. Contents are inside inserted fused cone.
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.1
The Warburg effect is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer ce...
Keywords: Aerobic, Cancer, Cell proliferation, Clinical, Glycolysis, PAGE, Phosphorylations, Transcription
Modulation of cellular radiation responses by 2-deoxy-D-glucose and other glycolytic inhibitors: implications for cancer therapy. Kalia VK, Prabhakara S, Narayanan V. J. Cancer Res. Ther. 5, S57-60, (2009)
A combination of 2-deoxy-D-glucose and 6-aminonicotinamide induces oxidative stress mediated selective radiosensitization of malignant cells via mitochondrial dysfunction. Bhardwaj R, Sharma PK, Jadon SS, Varshney R. Tumour Biol. 32, 951-964, (2011)
Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage. Rosa SC, Gonçalves J, Judas F, et al. Arthritis. Res. Ther. 11(3), R80, (2009)
Lithium prevents early cytosolic calcium increase and secondary injurious calcium overload in glycolytically inhibited endothelial cells. Bosche B, Schäfer M, Graf R, et al. Biochem. Biophys. Res. Commun. 434(2), 268-72, (2013)
Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy. Xi H, Barredo JC, Merchan JR, et al. Biochem. Pharmacol. 85(10), 1463-77, (2013)
Relationship between postprandial glucose level and carotid artery stiffness in patients without diabetes or cardiovascular disease. Watanabe K, Suzuki T, Ouchi M, et al. BMC Cardiovasc. Disord. 13, 11, (2013)
[Magnetic resonance spectroscopy of metabolic changes in mice brain after 2-deoxy-D-glucose injection]. Moshkin MP, Akulov AE, Petrovskiĭ DV, et al. Ross. Fiziol. Zh. Im. I. M. Sechenova 98(10), 1264-72, (2012)
Regulation of the proliferation of colon cancer cells by compounds that affect glycolysis, including 3-bromopyruvate, 2-deoxyglucose and biguanides. Lea MA, Qureshi MS, Buxhoeveden M, et al. Anticancer Res. 33(2), 401-7, (2013)
Cytotoxicity of chemotherapeutic agents in glyceraldehyde-3-phosphate dehydrogenase-depleted human lung carcinoma A549 cells with the accelerated senescence phenotype. Phadke M, Krynetskaia N, and Krynetskiy E Anticancer Drugs 24(4), 366-74, (2013)
D-Glucose and D-mannose-based metabolic probes. Part 3: Synthesis of specifically deuterated D-glucose, D-mannose, and 2-deoxy-D-glucose. Fokt I, Skora S, Conrad C, et al. Carbohydr. Res. 368, 111-9, (2013)
Sutherlandia frutescens prevents changes in diabetes-related gene expression in a fructose-induced insulin resistant cell model. Williams S, Roux S, Koekemoer T, et al. J. Ethnopharmacol. 146(2), 482-9, (2013)
Central glucagon-like peptide 1 receptor-induced anorexia requires glucose metabolism-mediated suppression of AMPK and is impaired by central fructose. Burmeister MA, Ayala J, Drucker DJ, et al. Am. J. Physiol. Endocrinol. Metab. 304(7), E677-85, (2013)
Jejunal proteins secreted by db/db mice or insulin-resistant humans impair the insulin signaling and determine insulin resistance. Salinari S, Debard C, Bertuzzi A, et al. PLoS ONE 8(2), e56258, (2013)
FT-IR 2 (1), 276:B / FT-IR 1 (1), 192:D / FT-NMR 1 (1), 296:B / IR-Spectra (2), 108:B / IR-Spectra (3), 116:F / NMR-Reference 2 (2), 909:B / RegBook 1 (1), 191:G / Sax 6, 867 / Sigma FT-IR 1 (1), 1054:B / Structure Index 1, 26:D:1
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