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D8375 Sigma

2-Deoxy-D-glucose

≥98% (GC), crystalline

Synonym: 2-Deoxy-D-arabinohexose, 2-Deoxyglucose

  • CAS Number 154-17-6

  • Empirical Formula (Hill Notation) C6H12O5

  • Molecular Weight 164.16

  •  Beilstein Registry Number 1723331

  •  EC Number 205-823-0

  •  MDL number MFCD00151328

  •  PubChem Substance ID 24894205

  • Popular Documents:  FTNMR (PDF)  

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Description

Application

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2-Deoxy-D-glucose (2-DG) is used in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR). 2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.

Packaging

1, 5, 25, 100 g in poly bottle

10 mg in glass bottle

Bottomless glass bottle. Contents are inside inserted fused cone.

Biochem/physiol Actions

2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Aerobic Glycolysis and the Warburg Effect

The Warburg effect is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer ce...
Keywords: Aerobic, Biofiles, Cancer, Cell proliferation, Clinical, Glycolysis, PAGE, Phosphorylations, Support, Transcription

Peer-Reviewed Papers
15

References

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