|Related Categories||Aerobic Glycolysis (the Warburg Effect), Biochemicals and Reagents, Cancer Metabolism, Cancer Research, Carbohydrate Library,|
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2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
10 mg in autosample vial
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.1
The Warburg effect is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer ce...
Keywords: Aerobic, Cancer, Cell proliferation, Clinical, Glycolysis, PAGE, Phosphorylations, Transcription
Modulation of cellular radiation responses by 2-deoxy-D-glucose and other glycolytic inhibitors: implications for cancer therapy. Kalia VK, Prabhakara S, Narayanan V. J. Cancer Res. Ther. 5, S57-60, (2009)
A combination of 2-deoxy-D-glucose and 6-aminonicotinamide induces oxidative stress mediated selective radiosensitization of malignant cells via mitochondrial dysfunction. Bhardwaj R, Sharma PK, Jadon SS, Varshney R. Tumour Biol. 32, 951-964, (2011)
FT-IR 2 (1), 276:B / FT-IR 1 (1), 192:D / FT-NMR 1 (1), 296:B / IR-Spectra (2), 108:B / IR-Spectra (3), 116:F / NMR-Reference 2 (2), 909:B / RegBook 1 (1), 191:G / Sax 6, 867 / Sigma FT-IR 1 (1), 1054:B / Structure Index 1, 26:D:1
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