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D8517 Sigma

Iron–Dextran

solution

Synonym: Ferric hydroxide dextran complex

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Properties

Related Categories Biochemicals and Reagents, Carbohydrates, Carbohydrates A to Z, Carbohydrates D-F, Polysaccharide More...
sterility   aseptically filled
form   solution
contains   0.5% phenol as preservative
composition   Iron, ~100 mg/mL

Description

Application

Iron-Dextran (ferric hydroxide dextran complex) may be used as an intravenous iron delivery preparation. Iron-Dextran may be used to induce iron-overload to study its effects and preventative measures.1,2

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Hazard Codes (Europe) 
T
Risk Statements (Europe) 
Safety Statements (Europe) 
53-36/37-45
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

1. Acute iron overload and oxidative stress in brain. Piloni NE, Fermandez V, Videla LA, et al. Toxicology 314(1), 174-82, (2013)

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2. [Establishment of an mouse model of iron-overload and its impact on bone marrow hematopoiesis]. Chai X, Zhao MF, Li DG, et al. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 35(5), 547-52, (2013)

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A comparative study of the physicochemical properties of iron isomaltoside 1000 (Monofer), a new intravenous iron preparation and its clinical implications. Jahn MR, Andreasen HB, Fütterer S, et al. Eur. J. Pharm. Biopharm. 78, 480-491, (2011)

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Assessment of the extent of oxidative stress induced by intravenous ferumoxytol,ferric carboxymaltose, iron sucrose and iron dextran in a nonclinical model. Toblli JE, Cao G, Oliveri L, Angerosa M. Arzneimittelforschung 61, 399-410, (2011)

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Safety profiles of total dose infusion of low-molecular-weight iron dextran and high-dose iron sucrose in renal patients. Atalay H, Solak Y, Acar K, Govec N, et al. Hemodial. Int. 15, 374-378, (2011)

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Differences in activation of mouse hepcidin by dietary iron and parenterally administered iron dextran: compartmentalization is critical for iron sensing. Daba A, Gkouvatsos K, Sebastiani G, et al. J. Mol. Med. 91(1), 95-102, (2013)

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A protocol for administering intravenous iron dextran in peritoneal dialysis patients. Huff J ANNA J. 25(4), 419-23, (1998)

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[Importance of the different i.v. iron generations for everyday medical practice]. Biggar P and Hahn KM MMW Fortschr. Med. 155 Suppl 1, 18-24, (2013)

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[Anaphylaxis after iron dextran administration in a pregnant woman]. Kortenhorst MS, Harmsze AM, and Hasaart TH Ned. Tijdschr. Geneeskd. 156(48), A5264, (2012)

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Effect of different iron loads on serum and tissue biochemical parameters and liver hepcidin mRNA abundance of neonatal piglets. Lia M, Yin Q, Dang X, et al. Arch. Anim. Nutr. 65(6), 477-85, (2011)

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Clinical practice guidelines for maintaining adequate iron status with intravenous iron dextran in hemodialysis patients. Peacock E and Lindenfeld SM ANNA J. 26(3), 337-43, (1999)

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Toxicity of parenteral iron dextran therapy. Burns DL and Pomposelli JJ Kidney Int. Suppl. 69, S119-24, (1999)

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Intravenous iron replacement for persistent iron deficiency anemia after Roux-en-Y gastric bypass. DeFilipp Z, Lister J, Gagné D, et al. Surg. Obes. Relat. Dis. 9(1), 129-32, (2013)

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Different effect of hydrogelation on antifouling and circulation properties of dextran-iron oxide nanoparticles. Karmali PP, Chao Y, Park JH, et al. Mol. Pharm. 9(3), 539-45, (2012)

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Mechanism of protective effects of Danshen against iron overload-induced injury in mice. Gao Y, Wang N, Zhang Y, et al. J. Ethnopharmacol. 145(1), 254-60, (2013)

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Parenteral iron dextran therapy. Kumpf VJ and Holland EG DICP 24(2), 162-6, (1990)

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Lower molecular weight intravenous iron dextran for restless legs syndrome. Cho YW, Allen RP, and Earley CJ Sleep Med. 14(3), 274-7, (2013)

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Comparative study of the iron cores in human liver ferritin, its pharmaceutical models and ferritin in chicken liver and spleen tissues using Mössbauer spectroscopy with a high velocity resolution. Alenkina IV, Oshtrakh MI, Klepova YV, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 100, 88-93, (2013)

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Dynamic contrast-enhanced ultrasound (DCE-US) for easy and rapid evaluation of hepatocellular carcinoma compared to dynamic contrast-enhanced computed tomography (DCE-CT)--a pilot study. Egger C, Goertz RS, Strobel D, et al. Ultraschall Med. 33(6), 587-92, (2012)

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Comparative rates of adverse events with different formulations of intravenous iron. Okam MM, Mandell E, Hevelone N, et al. Am. J. Hematol. 87(11), E123-4, (2012)

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Parenteral iron dextran therapy: a review. Burns DL, Mascioli EA, and Bistrian BR Nutrition 11(2), 163-8, (1995)

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Influence of iron chelation on R1 and R2 calibration curves in gerbil liver and heart. Wood JC Magn. Reson. Med. 60(1), 82-9, (2008)

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Design, synthesis, and testing of non-nephrotoxic desazadesferrithiocin polyether analogues. Bergeron RJ J. Med. Chem. 51(13), 3913-23, (2008)

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The comparative safety of intravenous iron dextran, iron saccharate, and sodium ferric gluconate. Fishbane S and Kowalski EA Semin. Dial. 13(6), 381-4, (2000)

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Intravenous low molecular weight iron dextran in children with iron deficiency anemia unresponsive to oral iron. Plummer ES, Crary SE, McCavit TL, et al. Pediatr. Blood Cancer 60(11), 1747-52, (2013)

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Use of intravenous iron supplementation in chronic kidney disease: an update. Macdougall IC and Geisser P Iran. J. Kidney Dis. 7(1), 9-22, (2013)

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The effect of different doses and types of intravenous iron on oxidative stress and inflammation in hemodialysis patients. Kumbasar A, Gursu M, Kaya C, et al. J. Nephrol. 25(5), 825-32, (2012)

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Timing iron dextran doses when plasmapheresis is required. Spruill WJ Clin. Pharm. 9(6), 419-20, (1990)

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Low molecular weight iron dextran increases fibroblast growth factor-23 concentration, together with parathyroid hormone decrease in hemodialyzed patients. Hryszko T, Rydzewska-Rosolowska A, Brzosko S, et al. Ther. Apher. Dial. 16(2), 146-51, (2012)

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Iron dextran treatment does not induce serum protein carbonyls in the newborn pig. Caperna TJ, Shannon AE, Blomberg LA, et al. Animal 6(1), 79-86, (2012)

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Total dose iron dextran infusion in cancer patients: is it SaFe2+? Gilreath JA, Stenehjem DD, and Rodgers GM J. Natl. Compr. Canc. Netw. 10(5), 669-76, (2012)

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Deferasirox shows in vitro and in vivo antileukemic effects on murine leukemic cell lines regardless of iron status. Lee DH, Jang PS, Chung NG, et al. Exp. Hematol. 41(6), 539-46, (2013)

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Nifedipine prevents iron accumulation and reverses iron-overload-induced dopamine neuron degeneration in the substantia nigra of rats. Ma Z, Zhou Y, and Xie J Neurotox. Res. 22(4), 274-9, (2012)

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Minimally invasive transdermal delivery of iron-dextran. Juluri A, Modepalli N, Jo S, et al. J. Pharm. Sci. 102(3), 987-93, (2013)

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The C57BL/6 genetic background confers cardioprotection in iron-overloaded mice. Musumeci M, Maccari S, Sestili P, et al. Blood Transfus. 11(1), 88-93, (2013)

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[Safety aspects of parenteral iron supplementation therapies in patients with chronic kidney disease]. Potthoff SA and Münch HG Dtsch. Med. Wochenschr. 138(24), 1312-7, (2013)

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Spondias pinnata stem bark extract lessens iron overloaded liver toxicity due to hemosiderosis in Swiss albino mice. Hazra B, Sarkar R, and Mandal N Ann. Hepatol. 12(1), 123-9, (2013)

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Evaluation of toxicity and oxidative stress induced by intravenous iron isomaltoside 1000 in a nonclinical model. Toblli JE, Cao G, Oliveri L, et al. Arzneimittelforschung 61(10), 553-65, (2011)

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Iron deficiency anemia in captive āalayan tapir calves (Tapirus indicus). Helmick KE and Milne VE J. Zoo Wildl. Med. 43(4), 876-84, (2012)

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Goodbye oral iron therapy? Forman E Pediatr. Blood Cancer 60(11), 1731, (2013)

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Intravenous or oral iron? Littlewood TJ Am. J. Hematol. 87(2), 134-5, (2012)

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Low-molecular weight iron dextran and iron sucrose have similar comparative safety profiles in chronic kidney disease. Auerbach M and Al Talib K Kidney Int. 73(5), 528-30, (2008)

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Is iron gluconate really safer than iron dextran? Eichbaum Q, Foran S, and Dzik S Blood 101(9), 3756-7, (2003)

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Should we still use iron dextran in hemodialysis patients? Hörl WH Am. J. Kidney Dis. 37(4), 859-61, (2001)

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Effects of intravenous iron on mononuclear cells during the haemodialysis session. Martin-Malo A, Merino A, et al. Nephrol. Dial. Transplant. 27(6), 2465-71, (2011)

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Merck 14,5094

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