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D8696 Sigma

DMH4

>99.0% (HPLC)

  • CAS Number 515880-75-8

  • Empirical Formula (Hill Notation) C24H24 N4O2

  • Molecular Weight 400.47

  •  MDL number MFCD18452839

Properties

Related Categories Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Merck,
assay   >99.0% (HPLC)
form   powder
storage condition   desiccated
color   off-white to brown
solubility   DMSO: soluble20 mg/mL
storage temp.   2-8°C

Description

Biochem/physiol Actions

DMH4 is a potent VEGF inhibitor and an angiogenesis inhbitor. It is a selective VEGF inhibitor with an IC50 of 161 nM for VEGFR inhibition compared to 8000 nM for AMPK. Unlike the structurally similar DMH1, which is a selective BMP inhibitor, DMH4 shows little affinitiy for BMP with an IC50 of 3500 nM for BMPR-I.

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