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D9160 Sigma

1-Deoxymannojirimycin hydrochloride

Synonym: 1,5-Dideoxy-1,5-imino-D-mannitol hydrochloride

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics A-F, Biochemicals and Reagents, Cell Biology,
InChI Key   ZJIHMALTJRDNQI-MVNLRXSJSA-N
assay   ≤98% (HPLC)
form   powder
mol wt   mol wt 199.63 g/mol
composition   Carbon (anhydrous), 35.2-37.2%
  Nitrogen (anhydrous), 6.8-7.4%
impurities   ≤8% Water (Karl Fischer)
solubility   H2O: soluble10 mg/mL
Mode of action   enzyme | inhibits
antibiotic activity spectrum   viruses
storage temp.   2-8°C

Description

Packaging

1, 5 mg in glass bottle

10 mg in poly bottle

Application

1-Deoxymannojirimycin (DMM) hydrochloride is an inhibitor of N-linked glycosylation and has antiviral activity. Derivatives of deoxymannojirimycin may have anti-HIV activity. It has been used for treatment of T lymphocytes and to study it′s effect on allogeneic cytotoxic T lymphocytes (CTL). It is used for studies on Golgi-mediated glycoprotein processing.

Biochem/physiol Actions

1-Deoxymannojirimycin is a mannosidase I inhibitor, alters cell-surface complex carbohydrate structure as assayed by PHA-L binding, and increases high mannose structures as indicated by the increased Con-A binding.

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Amplified Detection
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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