D9438 Sigma

DR4/Fc Chimera human

≥97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, cell culture tested

Synonym: Death Receptor 4, TRAIL-R1



Related Categories Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience, Death Receptors, Ligands and Antibodies, Death and Decoy Receptors More...
recombinant   expressed in baculovirus infected Sf21 cells
assay   ≥97% (SDS-PAGE)
form   lyophilized powder
potency   1-3 ng/mL ED50
mol wt   mol wt 46 kDa (glycosylated form)
impurities   endotoxin, tested
suitability   cell culture tested
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... TNFRSF10A(8797)


Analysis Note

Biological activity is measured by its ability to neutralize apoptosis of mouse L929 cells treated with 20 ng/ml recombinant human TRAIL or 12 ng/ml cross-linked recombinant human TRAIL.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5.0 mg bovine serum albumin.

Biochem/physiol Actions

DR4 is a type 1 membrane protein that is a member of the TNF receptor family. DR4 transduces apoptosis signal in a variety of transformed cell lines.

Price and Availability

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Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.


Certificate of Analysis

Protocols & Articles
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