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D9438 Sigma

DR4/Fc Chimera human

≥97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, cell culture tested

Synonym: Death Receptor 4, TRAIL-R1

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Properties

Related Categories Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience, Death Receptors, Ligands and Antibodies, Death and Decoy Receptors More...
recombinant   expressed in baculovirus infected Sf21 cells
assay   ≥97% (SDS-PAGE)
form   lyophilized powder
potency   1-3 ng/mL ED50
mol wt   mol wt 46 kDa (glycosylated form)
impurities   endotoxin, tested
suitability   cell culture tested
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... TNFRSF10A(8797)

Description

Analysis Note

Biological activity is measured by its ability to neutralize apoptosis of mouse L929 cells treated with 20 ng/ml recombinant human TRAIL or 12 ng/ml cross-linked recombinant human TRAIL.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5.0 mg bovine serum albumin.

Biochem/physiol Actions

DR4 is a type 1 membrane protein that is a member of the TNF receptor family. DR4 transduces apoptosis signal in a variety of transformed cell lines.

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Flow Cytometry Instruments
Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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