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D9439 Sigma

Desmosine chloride

from bovine, 99.5%±0.2%

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Properties

Related Categories Auxiliary Proteins, Biochemicals and Reagents, Other, Proteins and Derivatives
biological source   from bovine
InChI Key   FUPMLZCXPJSGPV-UHFFFAOYSA-N
assay   99.5%±0.2%
purified by   chromatography (and purified by solvent extraction)
storage temp.   2-8°C

Description

Analysis Note

Calibrated by UV and amino acid analysis.

Application

Assays for free or urinary desmosine are often used as markers for disease states characterized by elastin degradation (e.g., emphysema). Conversely, excessive levels of incorporated desmosine are indicators of fibrotic conditions (e.g., cirrhosis).

Desmosine chloride is often used in assays for free or urinary desmosine as markers for disease states characterized by elastin degradation (e.g., emphysema). Elastin degradation has shown strong correlation with vascular calcification, and pretreatment with aluminum ions can inhibit the binding of matrix metalloproteinase (MMP) to elastin.

Biochem/physiol Actions

Desmosine is a polyfunctional amino acid that forms cross-links in mature elastin.

Caution

Extremely hygroscopic

General description

Each vial contains 1 μmole of purified desmosine.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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