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D9533 Sigma

Deferoxamine mesylate salt

powder, ≥92.5% (TLC)

Synonym: DFOM, Deferoxamine methanesulfonate salt, Desferrioxamine mesylate salt

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Properties

Related Categories Aerobic Glycolysis (the Warburg Effect), Antioxidants and Cytoprotectants, Cancer Metabolism, Cancer Research, Cell Biology,
InChI Key   IDDIJAWJANBQLJ-UHFFFAOYSA-N
assay   ≥92.5% (TLC)
form   powder
color   white to off-white
solubility   H2O: soluble50 mg/mL
storage temp.   −20°C

Description

Biochem/physiol Actions

An iron chelator used often in the studies of cell proliferation and apoptosis. Has been shown to have anti-proliferative effects on vascular smooth muscle cells in vitro and in vivo and to arrest cells in the G1 phase. Also reported to induce p53. Induces apoptosis in HL-60 cells by chelating iron. After 48 hrs treatment with 1μM deferoxamine, DNA fragmentation was apparent. Cells treated with 0.1 μM deferoxamine for as little as 24 hours were committed to apoptosis; by 48 hrs nuclear collapse was observed. In some studies it has been shown to have antioxidant properties and to protect cells against H2O2-induced damage.

Deferoxamine is used as a hypoxia-mimetic agent to stabilize Hypoxia Inducible Factor 1 (HIF-1). Deferoxamine stabilizes HIF-1 through the inhibition of Prolyl Hydroxylases (PHDs) which target HIF-1 through degradation. The mechanism of deferoxamine inhibition is likely through the chelation of Fe2+ bound to the active site of PHD which is required for enzymatic activity.

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All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
UG5310000
Protocols & Articles

Articles

Oncogenes and Tumor Suppressors Reprogram Metabolism

Proliferating cells require the biosynthesis of structural components for biomass production and for genomic replication. This requires a reprogramming of the metabolic pathways to ensure nutrients s...
Keywords: Aerobic, Antitumor agents, Apoptosis, Biofiles, Cancer, Citric Acid Cycle, Degradations, Environmental, Events, Gene expression, Glycolysis, Growth factors, Metabolic Pathways, Metabolism, Metabolites, Nucleotide Synthesis, PAGE, Pentose phosphate pathway, Phosphorylations, Support

Viable but Nonculturable Bacteria

The expression “viable but nonculturable” (VNC) bacteria, describes cells that cannot normally be cultured. However this makes little sense, when one considers that the demonstration of culturability...
Jvo Siegrist
Microbiology Focus Edition 1.4
Keywords: Environmental, Gene expression, Metabolic Pathways, Methods, Microbiology

Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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