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D9891 Sigma

Doxycycline hyclate

≥98% (HPLC)

Synonym: Doxycycline hydrochloride hemiethanolate hemihydrate

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,
InChI Key   HALQELOKLVRWRI-ZVACAFRPSA-N
assay   ≥98% (HPLC)
form   powder
shelf life   4 yr
mol wt   mol wt 512.94 g/mol
composition   Nitrogen, 5.50-6.10%
impurities   ≤5% Water
solubility   Do you have solubility information on this product that you would like to share?
mp   ~201 °C
solubility   H2O: soluble50 mg/mL
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
  mycoplasma
  parasites
storage temp.   2-8°C

Description

Frequently Asked Questions

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Application

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Doxycycline hyclate is a synthetic oxytetracycline derivative. It has been used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks. It is a broad spectrum inhibitor used to inhibit matrix metalloproteinases (MMP), such as type 1 collagenase in studies on wound healing and tissue remodeling.

Packaging

1, 5, 10, 25, 100 g in glass bottle

Biochem/physiol Actions

Doxycycline hyclate inhibits the inflammatory response to the Lyme Disease Spirochete Borrelia burgdorferi. It is a broad spectrum inhibitor of matrix metalloproteinases in vivo.

Protocols & Applications

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
QI8925000
Protocols & Articles

Related Content

Bio Brief: Doxycycline Hyclate [VIDEO]

Doxycycline hyclate is a semisynthetic tetracycline functioning as a broad spectrum antibiotic and bacteriostatic agent effective against Gram-positive and Gram-negative bacteria. The recommended usa...
Keywords: Antibiotics, Apoptosis, Cancer, Cell culture, Gene expression, Gene knockdown

Peer-Reviewed Papers
15

References

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