Synonym: Doxycycline hydrochloride hemiethanolate hemihydrate
|Related Categories||A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,|
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Doxycycline hyclate is a synthetic oxytetracycline derivative. It has been used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks1. It is used to inhibit matrix metalloproteinases2 and has been used to inhibit the inflammatory response of Lyme Disease3.
Derivative of oxytetracycline. A broad spectrum inhibitor used to inhibit matrix metallo-proteinases (MMP) such as type 1 collagenase in studies on would healing and tissue remodeling.
Doxycycline hyclate inhibits the inflammatory response to the Lyme Disease Spirochete Borrelia burgdorferi3. It is a broad spectrum inhibitor of matrix metalloproteinases in vivo.
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|Precautionary statements||P261-P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xn|
|Risk Statements (Europe)||22-36/37/38|
|Safety Statements (Europe)||26|
Increasing antibiotic resistance and the lack of new drug development have hindered the success of antibiotics in recent years. Staph aureus is susceptible to a number of antibiotics with various mec...
Doxycycline hyclate is a semisynthetic tetracycline functioning as a broad spectrum antibiotic and bacteriostatic agent effective against Gram-positive and Gram-negative bacteria. The recommended usa...
Keywords: Antibiotics, Apoptosis, Cancer, Cell culture, Gene expression, Gene knockdown
1. Elimination of Borrelia burgdorferi and Anaplasma phagocytophilum in Rodent Reservoirs and Ixodes scapularis Ticks Using a Doxycycline Hyclate-Laden Bait Marc C. Dolan, Terry L. Schulze, et al. Am. J. Trop. Med. Hyg. 85, 1114-1120, (2011)
3. The Antibiotics Doxycycline and Minocycline Inhibit the Inflammatory Responses to the Lyme Disease Spirochete Borrelia burgdorferi Andrea L. F. Bernardino, Deepak Kaushal, et al. J. Infect. Dis. 199, 1379-1388, (2009)
Clinical manifestations, laboratory findings, and therapeutic regimen in hospitalized children with brucellosis in an Iranian Referral Children Medical Centre. Fanni F, Shahbaznejad L, Pourakbari B, et al. J. Health. Popul. Nutr. 31(2), 218-22, (2013)
Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity. Johnson SL, Kuhn S, Franz C, et al. Proc. Natl. Acad. Sci. U. S. A. 110(21), 8720-5, (2013)
Determination of doxycycline in chicken fat by liquid chromatography with UV detection and liquid chromatography-tandem mass spectrometry. Gajda A, Posyniak A, Zmudzki J, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 928, 113-20, (2013)
High error rates in selenocysteine insertion in mammalian cells treated with the antibiotic doxycycline, chloramphenicol, or geneticin. Tobe R, Naranjo-Suarez S, Everley RA, et al. J. Biol. Chem. 288(21), 14709-15, (2013)
[Complete atrio-ventricular block as a first symptom of borreliosis: antibiotic treatment instead of pacemaker implantation]. Kaczmarek K, Deroń Z, Janiszewski T, et al. Kardiol. Pol. 71(2), 205-7, (2013)
[Combined laser therapy of the reactivated form of cytomegalovirus infection of the urogenital tract in the women of reproductive age]. Perlamutrov IuN, Chernova NI, Ol'khovskaia KB, et al. Vopr. Kurortol. Fizioter. Lech. Fiz. Kult. (3), 45-51, (2013)
Conditional overexpression of receptors for advanced glycation end-products in the adult murine lung causes airspace enlargement and induces inflammation. Stogsdill MP, Stogsdill JA, Bodine BG, et al. Am. J. Respir. Cell. Mol. Biol. 49(1), 128-34, (2013)
Doxycycline-regulated 3T3-L1 preadipocyte cell line with inducible, stable expression of adenoviral E4orf1 gene: a cell model to study insulin-independent glucose disposal. Krishnapuram R, Dhurandhar EJ, Dubuisson O, et al. PLoS ONE 8(3), e60651, (2013)
Molecular interactions between matrilysin and the matrix mettalloproteinase inhibitor doxycycline investigated by deuterium exchange mass spectrometry. Garcia, R.A. et al., Mol. Pharmacol. 67, 1128-36, (2005)
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|Z672548||PAP pen for immunostaining, 2 mm tip width|
|O5875||Oxytetracycline hydrochloride, ≥95% (HPLC), crystalline|
|D6140||Demeclocycline hydrochloride, ≥90% (HPLC), powder|
|M9511||Minocycline hydrochloride, crystalline|
|P8833||Puromycin dihydrochloride from Streptomyces alboniger, powder, BioReagent, suitable for cell culture|
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|44577||Doxycycline hyclate, ≥98.0% (TLC)|
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