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  • E0143 - Monoclonal Anti-Episialin (EMA) antibody produced in mouse

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E0143 Sigma

Monoclonal Anti-Episialin (EMA) antibody produced in mouse

clone GP1.4, ascites fluid

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Extracellular Matrix, Antibodies to Extracellular Matrix Proteins,
species reactivity   human
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using formalin-fixed, paraffin-embedded sections of human breast carcinoma
  immunohistochemistry (frozen sections): suitable
  immunoprecipitation: suitable
  microarray: suitable
clone   GP1.4, monoclonal
antibody form   ascites fluid
isotype   IgG1
contains   15 mM sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... MUC1(4582)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

human milk fat globule membranes.

General description

Episialin (mucin-1) is an epithelial transmembrane oncoprotein that occurs in glandular tissues. This oncoprotein mediates ErbB1 receptor transport and subsequently regulates cell survival. Episialin also modulates p53-responsive genes under conditions of genotoxic stress and also co-activates the transcription of Wnt target genes. Overexpression of Episialin has been associated with most human cancers
Monoclonal Anti-Episialin (EMA) antibody is specific for the repetitive protein epitope on the episialin long extracellular domain. This epitope is relatively insensitive to glycosylation. The antibody stains 2 bands (ranging between 265-400 kD) by immunoblotting. The product also reacts with highly glycosylated episialin in epithelial cell tumors and large cell anaplastic lymphomas. In immunohistological assays, enzymatic pre-treatment of formalin-fixed, paraffin-embedded sections may enhance the staining intensity.

Application

Monoclonal Anti-Episialin (EMA) antibody is suitable for use in immunohistochemistry (1:200 using formalin-fixed, paraffin-embedded sections of human breast carcinoma), immunoprecipitation and microarray.

Features and Benefits

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