|Related Categories||Cell Biology, Cell Signaling and Neuroscience, Ion Channels, Ligand-Gated Ion Channels, Nicotinic Acetylcholine Receptor Modulators More...|
|solubility||H2O: soluble10 mg/mL|
Material is highly toxic
(+)-Epibatidine is a non-opioid analgesic alkaloid isolated from skin of Ecuadoran tree frog, Epipedobates tricolor; naturally-occurring isomer of the most potent nicotinic acetylcholine receptor agonist known. Discoveries in the nAChR field have stimulated interest in nAChR-targeted compounds as potential analgesic agents. Epibatidine has full efficacy relative to opioids in preclinical pain models. Although epibatidine is toxic, these observations demonstrated that modest efficacy is not a general limitation of nAChR agonists. Moreover, exploration of the molecular biology of nAChRs revealed evidence of receptor diversity, suggesting that nAChR subtype-selective agents are less toxic than nicotine; and early medicinal chemistry efforts have resulted in compounds with improved safety profiles.
|Precautionary statements||P264-P280-P302 + P350-P310|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T+|
|Risk Statements (Europe)||27/28|
|Safety Statements (Europe)||28-36/37-45|
|RIDADR||UN 2811 6.1 / PGI|
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