(+)-Epibatidine dihydrochloride
≥98% (HPLC), solid
DOWNLOAD MSDS (PDF)Synonym:
exo-(+)-1R,2R,4S-
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CAS Number 166374-43-2
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Empirical Formula (Hill Notation) C11H13N2Cl · 2HCl
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Molecular Weight 281.61
Properties
| Related Categories | Cell Biology, Cell Signaling and Neuroscience, Ion Channels, Ligand-Gated Ion Channels, Nicotinic Acetylcholine Receptor Modulators More... |
| assay | ≥98% (HPLC) |
| form | solid |
| color | white |
| solubility | H2O: soluble10 mg/mL |
Description
Caution
Material is highly toxic
Biochem/physiol Actions
(+)-Epibatidine is a non-opioid analgesic alkaloid isolated from skin of Ecuadoran tree frog, Epipedobates tricolor; naturally-occurring isomer of the most potent nicotinic acetylcholine receptor agonist known. Discoveries in the nAChR field have stimulated interest in nAChR-targeted compounds as potential analgesic agents. Epibatidine has full efficacy relative to opioids in preclinical pain models. Although epibatidine is toxic, these observations demonstrated that modest efficacy is not a general limitation of nAChR agonists. Moreover, exploration of the molecular biology of nAChRs revealed evidence of receptor diversity, suggesting that nAChR subtype-selective agents are less toxic than nicotine; and early medicinal chemistry efforts have resulted in compounds with improved safety profiles.
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