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E0409 Sigma

Monoclonal Anti-EDEM3 antibody produced in mouse

~1.0 mg/mL, clone EDEM3-1, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-ER degradation enhancer, mannosidase α-like 3

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Cell Stress, Antibodies to Oxidative Stress Proteins,
species reactivity   human, mouse, rat
application(s)   western blot: 1-2 μg/mL using whole extract of mouse 3T3 or rat NRK cells
clone   EDEM3-1, monoclonal
concentration   ~1.0 mg/mL
antibody form   purified immunoglobulin
form   buffered aqueous solution
mol wt   antigen mol wt ~120 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... EDEM3(80267)
mouse ... Edem3(66967)
rat ... Edem3(289085)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 869-882 of human EDEM3, conjugated to KLH. The corresponding sequence is identical in mouse and rat EDEM3.

General description

Three EDEM homologs, EDEM1, EDEM2 and EDEM3 have been identified, which are transcriptionally upregulated upon ER stress by the activated IRE1/Xbp-1 branch.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

Monoclonal Anti-EDEM3 antibody produced in mouse is suitable for immunoblotting at a working concentration of 1-2μg/mL using a whole extract of mouse 3T3 or rat NRK cells.

Features and Benefits

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Biochem/physiol Actions

EDEM3 (ER degradation enhancer, mannosidase α-like 3), a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation (ERAD) and mannose trimming. EDEM3 accelerates ERAD of misfolded glycoproteins as well, but in ontrast to EDEM1, it greatly stimulates mannosidase trimming in vivo.

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Safety Information

WGK Germany  1
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Peer-Reviewed Papers
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References

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