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E0657 Sigma

Monoclonal Anti-phospho-Epidermal Growth Factor Receptor (pTyr1068) antibody produced in mouse

clone 338324, purified immunoglobulin, lyophilized powder

Synonym: Monoclonal Anti-EGFR, Monoclonal Anti-ERBB, Monoclonal Anti-HER1, Monoclonal Anti-PIG61

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cytokines and Growth Factors, Antibodies to Epidermal Growth Factors (EGF) and NRG Family,
species reactivity   human
application(s)   flow cytometry: 5 μg/mL
  western blot: 1 μg/mL
clone   338324, monoclonal
antibody form   purified immunoglobulin
form   lyophilized powder
isotype   IgG2a
storage temp.   −20°C
Gene Information   human ... EGFR(1956)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

purified, synthetic phosphopeptide corresponding to residues surrounding tyrosine 1068 of human epidermal growth factor receptor.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Features and Benefits

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Biochem/physiol Actions

EGFR is a transmembrane glycoprotein that binds to the EGF family. It is a pivotal regulator of cell proliferation, growth, differentiation and DNA repair after radiation-induced damage. Mutations in the gene encoding EGFR are associated with a number of malignancies including lung cancer and colorectal cancer. Tyr1068 is a minor autophosphorylation site and enables the binding of EGFR to GAB-1 or Grb2.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  3
Protocols & Articles

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Antibody Explorer | Buy Primary & Secondary Antibodies

Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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