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E1032 Sigma

Anti-EN-RAGE antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-CAGC, Anti-S100 calcium binding protein A12, Anti-S100A12, Anti-p6

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Extracellular Matrix, Antibodies to Extracellular Matrix Proteins,
species reactivity   human
application(s)   flow cytometry: 3-10 μg/mL
  immunohistochemistry: 5-15 μg/mL
  western blot: 0.1-0.2 μg/mL
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   human ... S100A12(6283)
biological source   goat
conjugate   unconjugated

Description

Immunogen

purified, E. coli-derived recombinant human extracellular RAGE-binding protein.

General description

EN-RAGE is a member of the S100/calgranulin superfamily.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Application

Anti-EN-RAGE antibody produced in goat is suitable for western blot analysis at a working concentration of 0.1–0.2μg/mL, immunohistochemistry at 5-15μg/mL and flow cytometry at 3-10μg/mL/106 cells.

Features and Benefits

Antibody Bioguarantee
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Biochem/physiol Actions

The gene encodes a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It stimulates innate immune cells via binding to receptor for advanced glycation end products (AGER), which activates the MAP-kinase and NF-κ-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. It also stimulates mast cell degranulation and activation which generates chemokines, histamine and cytokines with leukocyte recruitment to the sites of inflammation.

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  NONH for all modes of transport
WGK Germany  1
Protocols & Articles

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Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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