β-Estradiol

Papers

Design, Synthesis, And Biological Evaluation Of Novel Estradiol-bisphosphonate Conjugates As Bone-specific Estrogens. Morioka, M., et al. Bioorg. Med. Chem. 18, 1143-8, (2010)

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Indazole estrogens: highly selective ligands for the estrogen receptor beta. Meri De Angelis et al J. Med. Chem. 48, 1132-44, (2005)

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Binding thermodynamics as a tool to investigate the mechanisms of drug-receptor interactions: thermodynamics of cytoplasmic steroid/nuclear receptors in comparison with membrane receptors. Paola Gilli et al J. Med. Chem. 48, 2026-35, (2005)

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Discovery of novel quinoline-based estrogen receptor ligands using peptide interaction profiling. William J Hoekstra et al J. Med. Chem. 48, 2243-7, (2005)

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Selective estrogen receptor modulators in the ruthenocene series. Synthesis and biological behavior. Pascal Pigeon et al J. Med. Chem. 48, 2814-21, (2005)

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Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Giulia Caron et al J. Med. Chem. 48, 3269-79, (2005)

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Selective estrogen receptor modulators with conformationally restricted side chains. Synthesis and structure-activity relationship of ERalpha-selective tetrahydroisoquinoline ligands. Johanne Renaud et al J. Med. Chem. 48, 364-79, (2005)

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ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. Richard E Mewshaw et al J. Med. Chem. 48, 3953-79, (2005)

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Synthesis and evaluation of (17alpha,20Z)-21-(4-substituted-phenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17beta-diols as ligands for the estrogen receptor-alpha hormone binding domain: comparison with 20E-isomers. Robert N Hanson et al J. Med. Chem. 48, 4300-11, (2005)

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Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals. Markus A Lill et al J. Med. Chem. 48, 5666-74, (2005)

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Differential response of estrogen receptor subtypes to 1,3-diarylindene and 2,3-diarylindene ligands. Nicola J Clegg et al J. Med. Chem. 48, 5989-6003, (2005)

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Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol. Jeongsoo Yoo et al J. Med. Chem. 48, 6366-78, (2005)

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Synthesis and pharmacological evaluation of 1H-imidazoles as ligands for the estrogen receptor and cytotoxic inhibitors of the cyclooxygenase. Thomas Wiglenda et al J. Med. Chem. 48, 6516-21, (2005)

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Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study. Cynthia D Selassie et al J. Med. Chem. 48, 7234-42, (2005)

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Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers. Timothy A Blizzard et al Bioorg. Med. Chem. Lett. 15, 107-13, (2005)

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Identification of an agonist ligand for estrogen-related receptors ERRbeta/gamma. Donna D Yu et al Bioorg. Med. Chem. Lett. 15, 1311-3, (2005)

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Structure-activity relationships and sub-type selectivity in an oxabicyclic estrogen receptor alpha/beta agonist scaffold. Lawrence G Hamann et al Bioorg. Med. Chem. Lett. 15, 1463-6, (2005)

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Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs. Qiang Tan et al Bioorg. Med. Chem. Lett. 15, 1675-81, (2005)

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Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones. Robert E McDevitt et al Bioorg. Med. Chem. Lett. 15, 3137-42, (2005)

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Estrogen receptor ligands. Part 13: Dihydrobenzoxathiin SERAMs with an optimized antagonist side chain. Timothy A Blizzard et al Bioorg. Med. Chem. Lett. 15, 3912-6, (2005)

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ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. An T Vu et al Bioorg. Med. Chem. Lett. 15, 4520-5, (2005)

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Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands. Richard Chesworth et al Bioorg. Med. Chem. Lett. 15, 5562-6, (2005)

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Estrogen receptor ligands. Part 11: Synthesis and activity of isochromans and isothiochromans. Jian Liu et al Bioorg. Med. Chem. Lett. 15, 715-8, (2005)

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UDP-glucuronosyltransferases and clinical drug-drug interactions. Tony K L Kiang et al Pharmacol. Ther. 106, 97-132, (2005)

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Daucane sesquiterpenes from Ferula hermonis. Amélie Lhuillier et al J. Nat. Prod. 68, 468-71, (2005)

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The transgenic Arabidopsis plant system, pER8-GFP, as a powerful tool in searching for natural product estrogen-agonists/antagonists. Fang-Rong Chang et al J. Nat. Prod. 68, 971-3, (2005)

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Synthesis and characterization of 3-arylquinazolinone and 3-arylquinazolinethione derivatives as selective estrogen receptor beta modulators. Timur Güngör et al J. Med. Chem. 49, 2440-55, (2006)

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Synthesis of anthranylaldoxime derivatives as estrogen receptor ligands and computational prediction of binding modes. Tiziano Tuccinardi et al J. Med. Chem. 49, 5001-12, (2006)

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A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies. Olaf Kinzel et al J. Med. Chem. 49, 5404-7, (2006)

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Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen receptors alpha and beta. Frederik Roelens et al J. Med. Chem. 49, 7357-65, (2006)

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Progressive docking: a hybrid QSAR/docking approach for accelerating in silico high throughput screening. Artem Cherkasov et al J. Med. Chem. 49, 7466-78, (2006)

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6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Wanying Sun et al Bioorg. Med. Chem. Lett. 16, 1468-72, (2006)

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Synthesis and biological activities of nucleoside-estradiol conjugates. Hasrat Ali et al Bioorg. Med. Chem. Lett. 16, 317-9, (2006)

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The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands. R R Wilkening et al Bioorg. Med. Chem. Lett. 16, 3489-94, (2006)

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Estrogen receptor beta-subtype selective tetrahydrofluorenones: use of a fused pyrazole as a phenol bioisostere. R R Wilkening et al Bioorg. Med. Chem. Lett. 16, 3896-901, (2006)

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Triazolo-tetrahydrofluorenones as selective estrogen receptor beta agonists. Dann L Parker et al Bioorg. Med. Chem. Lett. 16, 4652-6, (2006)

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A novel oxazine ring closure reaction affording (Z)-((E)-2-styrylbenzo[b]furo[3,2-d][1,3]oxazin-4-ylideno)acetaldehydes and their anti-osteoclastic bone resorption activity. Yuko Ando et al Bioorg. Med. Chem. Lett. 16, 5849-54, (2006)

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Androstenediol analogs as ER-beta-selective SERMs. Timothy A Blizzard et al Bioorg. Med. Chem. Lett. 16, 834-8, (2006)

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Polyphenolic constituents of Actaea racemosa. Paiboon Nuntanakorn et al J. Nat. Prod. 69, 314-8, (2006)

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Virtual and biomolecular screening converge on a selective agonist for GPR30. Cristian G Bologa et al Nat. Chem. Biol. 2, 207-12, (2006)

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Identifying off-target effects and hidden phenotypes of drugs in human cells. Marnie L MacDonald et al Nat. Chem. Biol. 2, 329-37, (2006)

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Improved anti-osteoporosis potency and reduced endometrial membrane hyperplasia during hormone replacement therapy with estrogen-RGD peptide conjugates. Yu Xiong et al J. Med. Chem. 50, 3340-53, (2007)

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Design, synthesis, and estrogenic activity of a novel estrogen receptor modulator--a hybrid structure of 17beta-estradiol and vitamin E in hippocampal neurons. Liqin Zhao et al J. Med. Chem. 50, 4471-81, (2007)

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Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors. Yukihiro Itoh et al J. Med. Chem. 50, 5425-38, (2007)

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Synthesis and evaluation of the antiproliferative activities of derivatives of carboxyalkyl isoflavones linked to N-t-Boc-hexylenediamine. Fortune Kohen et al J. Med. Chem. 50, 6405-10, (2007)

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Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics. Barnaby C H May et al J. Med. Chem. 50, 65-73, (2007)

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Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. Jen-Liang Su et al J. Biol. Chem. 282, 19385-98, (2007)

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Estrogen receptor beta ligands: design and synthesis of new 2-phenyl-isoindole-1,3-diones. John W Ullrich et al Bioorg. Med. Chem. Lett. 17, 118-22, (2007)

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Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERalpha. Kevin D Dykstra et al Bioorg. Med. Chem. Lett. 17, 2322-8, (2007)

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Bridged androstenediol analogs as ER-beta selective SERMs. Timothy A Blizzard et al Bioorg. Med. Chem. Lett. 17, 2944-8, (2007)

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Synthesis, characterization, and estrogen receptor binding affinity of flavone-, indole-, and furan-estradiol conjugates. Naseem Ahmed et al Bioorg. Med. Chem. Lett. 17, 3212-6, (2007)

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ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands. An T Vu et al Bioorg. Med. Chem. Lett. 17, 4053-6, (2007)

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Androstene-3,5-dienes as ER-beta selective SERMs. Timothy A Blizzard et al Bioorg. Med. Chem. Lett. 17, 6295-8, (2007)

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ERbeta ligands. Part 5: synthesis and structure-activity relationships of a series of 4'-hydroxyphenyl-aryl-carbaldehyde oxime derivatives. Richard E Mewshaw et al Bioorg. Med. Chem. Lett. 17, 902-6, (2007)

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Synthesis, structure, and estrogenic activity of 4-amino-3-(2-methylbenzyl)coumarins on human breast carcinoma cells. Yves Jacquot et al Bioorg. Med. Chem. 15, 2269-82, (2007)

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Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bram Baert et al Bioorg. Med. Chem. 15, 6943-55, (2007)

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C6-(N,N-butyl-methyl-heptanamide) derivatives of estrone and estradiol as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: Chemical synthesis and biological evaluation. Christine Cadot et al Bioorg. Med. Chem. 15, 714-26, (2007)

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Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. Christopher A Elkins et al Antimicrob. Agents Chemother. 51, 923-9, (2007)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. Hiroyuki Sato et al J. Med. Chem. 51, 1831-41, (2008)

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An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin. Artem Cherkasov et al J. Med. Chem. 51, 2047-56, (2008)

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Synthesis and screening of mono- and di-aryl technetium and rhenium metallocarboranes. A new class of probes for the estrogen receptor. Patrick W Causey et al J. Med. Chem. 51, 2833-44, (2008)

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Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Jenny M Pedersen et al J. Med. Chem. 51, 3275-87, (2008)

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Synthesis and evaluation of estrogen agonism of diaryl 4,5-dihydroisoxazoles, 3-hydroxyketones, 3-methoxyketones, and 1,3-diketones: a compound set forming a 4D molecular library. Juha T Pulkkinen et al J. Med. Chem. 51, 3562-71, (2008)

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Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design, synthesis, biological evaluation, and pharmacokinetics. Sandrine Marchais-Oberwinkler et al J. Med. Chem. 51, 4685-98, (2008)

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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Gustav Ahlin et al J. Med. Chem. 51, 5932-42, (2008)

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

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Promising core structure for nuclear receptor ligands: design and synthesis of novel estrogen receptor ligands based on diphenylamine skeleton. Kiminori Ohta et al Bioorg. Med. Chem. Lett. 18, 5050-3, (2008)

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Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands. Jing Fang et al Bioorg. Med. Chem. Lett. 18, 5075-7, (2008)

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Estradiol and estrone C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: blocking of ER+ breast cancer cell proliferation induced by estrone. Yannick Laplante et al Bioorg. Med. Chem. 16, 1849-60, (2008)

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Structure and estrogenic activity of new lignans from Iryanthera lancifolia. Dulce Mesa-Siverio et al Bioorg. Med. Chem. 16, 3387-94, (2008)

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Ebenfurans IV-VIII from Onobrychis ebenoides: evidence that C-prenylation is the key determinant of the cytotoxicity of 3-formyl-2-arylbenzofurans. Maria Halabalaki et al J. Nat. Prod. 71, 1934-7, (2008)

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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. R Scott Obach et al Drug Metab. Dispos. 36, 1385-405, (2008)

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Novel dehydroepiandrosterone derivatives with antiapoptotic, neuroprotective activity. Theodora Calogeropoulou et al J. Med. Chem. 52, 6569-87, (2009)

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Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone. Edith Bellavance et al J. Med. Chem. 52, 7488-502, (2009)

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Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta. Filippo Minutolo et al J. Med. Chem. 52, 858-67, (2009)

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Biphenyl C-cyclopropylalkylamides: New scaffolds for targeting estrogen receptor beta. Miranda J Sarachine et al Bioorg. Med. Chem. Lett. 19, 2404-8, (2009)

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Structure-based design, synthesis and in vitro characterization of potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors based on 2-substitutions of estrone and D-homo-estrone. Gabriele Möller et al Bioorg. Med. Chem. Lett. 19, 6740-4, (2009)

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Bone selective effect of an estradiol conjugate with a novel tetracycline-derived bone-targeting agent. Jason R Neale et al Bioorg. Med. Chem. Lett. 19, 680-3, (2009)

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Synthesis and evaluation of aryl-substituted diarylpropionitriles, selective ligands for estrogen receptor beta, as positron-emission tomographic imaging agents. Byung Seok Moon et al Bioorg. Med. Chem. 17, 3479-88, (2009)

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Steroidal bivalent ligands for the estrogen receptor: design, synthesis, characterization and binding affinities. Andrew L LaFrate et al Bioorg. Med. Chem. 17, 3528-35, (2009)

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3D QSAR of novel estrogen-RGD peptide conjugates: getting insight into structural dependence of anti-osteoporosis activity and side effect of estrogen in ERT. Ming Zhao et al Bioorg. Med. Chem. 17, 3680-9, (2009)

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Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Lei Du-Cuny et al Bioorg. Med. Chem. 17, 6983-92, (2009)

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Synthesis, evaluation and 3D QSAR analysis of novel estradiol-RGD octapeptide conjugates with oral anti-osteoporosis activity. Jiangyuan Liu et al Eur. J. Med. Chem. 44, 1689-704, (2009)

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Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta. Michael Waibel et al Eur. J. Med. Chem. 44, 3412-24, (2009)

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Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)

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Steroidal lactones as inhibitors of 17beta-hydroxysteroid dehydrogenase type 5: chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities. Patrick Bydal et al Eur. J. Med. Chem. 44, 632-44, (2009)

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Isoflavonoids from Erythrina poeppigiana: evaluation of their binding affinity for the estrogen receptor. Sefirin Djiogue et al J. Nat. Prod. 72, 1603-7, (2009)

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The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144. Deborah M Roll et al J. Nat. Prod. 72, 1944-8, (2009)

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Bioactivity-guided mapping and navigation of chemical space. Steffen Renner et al Nat. Chem. Biol. 5, 585-92, (2009)

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Synthesis and characterization of iodinated tetrahydroquinolines targeting the G protein-coupled estrogen receptor GPR30. Chinnasamy Ramesh et al J. Med. Chem. 53, 1004-14, (2010)

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Structure-function relationships of estrogenic triphenylethylenes related to endoxifen and 4-hydroxytamoxifen. Philipp Y Maximov et al J. Med. Chem. 53, 3273-83, (2010)

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Synthesis and evaluation of 17alpha-arylestradiols as ligands for estrogen receptor alpha and beta. David Sedlák et al J. Med. Chem. 53, 4290-4, (2010)

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Discovery of potent ligands for estrogen receptor beta by structure-based virtual screening. Jie Shen et al J. Med. Chem. 53, 5361-5, (2010)

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Effects of 7-O substitutions on estrogenic and anti-estrogenic activities of daidzein analogues in MCF-7 breast cancer cells. Quan Jiang et al J. Med. Chem. 53, 6153-63, (2010)

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Synthesis and biochemical characterization of a series of 17?-perfluoroalkylated estradiols as selective ligands for estrogen receptor ?. Barbara Eignerová et al J. Med. Chem. 53, 6947-53, (2010)

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Aldehyde oxidase: an enzyme of emerging importance in drug discovery. David C Pryde et al J. Med. Chem. 53, 8441-60, (2010)

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A mutant selective anti-estrogen is a pure antagonist on EREs and AP-1 response elements. Disha Jain et al Bioorg. Med. Chem. Lett. 20, 5258-61, (2010)

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3-O-phosphate ester conjugates of 17-?-O-{1-[2-carboxy-(2-hydroxy-4-methoxy-3-carboxamido)anilido]ethyl}1,3,5(10)-estratriene as novel bone-targeting agents. Shama Nasim et al Bioorg. Med. Chem. Lett. 20, 7450-3, (2010)

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Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Francisco J Prado-Prado et al Bioorg. Med. Chem. 18, 2225-31, (2010)

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Synthesis and biological evaluation of phenolic 4,5-dihydroisoxazoles and 3-hydroxy ketones as estrogen receptor alpha and beta agonists. Pekka K Poutiainen et al Bioorg. Med. Chem. 18, 3437-47, (2010)

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Genomic action of permanently charged tamoxifen derivatives via estrogen receptor-alpha. Claudia Rivera-Guevara et al Bioorg. Med. Chem. 18, 5593-601, (2010)

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Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships. Shigeo Hayashi et al Bioorg. Med. Chem. 18, 7675-99, (2010)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Membrane transporters in drug development Giacomini, K.M., et al. Nat. Rev. Drug Discov. 9, 215-236, (2010)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Design and evaluation of fragment-like estrogen receptor tetrahydroisoquinoline ligands from a scaffold-detection approach. Sabine Möcklinghoff et al J. Med. Chem. 54, 2005-11, (2011)

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A-CD estrogens. I. Substituent effects, hormone potency, and receptor subtype selectivity in a new family of flexible estrogenic compounds. James S Wright et al J. Med. Chem. 54, 433-48, (2011)

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Design and synthesis of tricyclic tetrahydroquinolines as a new series of nonsteroidal selective androgen receptor modulators (SARMs). Naoya Nagata et al Bioorg. Med. Chem. Lett. 21, 1744-7, (2011)

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Sulfonamides as selective oestrogen receptor ? agonists. Lee R Roberts et al Bioorg. Med. Chem. Lett. 21, 5680-3, (2011)

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Tetrahydroquinolines as a novel series of nonsteroidal selective androgen receptor modulators: structural requirements for better physicochemical and biological properties. Naoya Nagata et al Bioorg. Med. Chem. Lett. 21, 6310-3, (2011)

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Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs. Latanya M Scott et al Bioorg. Med. Chem. Lett. 21, 730-3, (2011)

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Synthesis and biological evaluation of estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates as potential anticancer agents. Ahmed Kamal et al Bioorg. Med. Chem. 19, 2565-81, (2011)

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QSAR-based permeability model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 19, 2615-24, (2011)

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New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription. C. Villalonga-Barber, et al., Bioorg. Med. Chem. 19, 339-351, (2011)

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DNA site-specific N3-adenine methylation targeted to estrogen receptor-positive cells. Rigel J Kishton et al Bioorg. Med. Chem. 19, 5093-102, (2011)

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Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes. Simone Bertini et al Eur. J. Med. Chem. 46, 2453-62, (2011)

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FDA-approved drug labeling for the study of drug-induced liver injury. Minjun Chen et al Drug Discov. Today 16, 697-703, (2011)

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Using the pER8:GUS reporter system to screen for phytoestrogens from Caesalpinia sappan. Wan-Chun Lai et al J. Nat. Prod. 74, 1698-706, (2011)

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Estrogenic activity of chemical constituents from Tephrosia candida. Mohamed-Elamir F Hegazy et al J. Nat. Prod. 74, 937-42, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Diarylpropionitrile (DPN) enantiomers: synthesis and evaluation of estrogen receptor ?-selective ligands. Vincent M Carroll et al J. Med. Chem. 55, 528-37, (2012)

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Constituents of Dalbergia sissoo Roxb. leaves with osteogenic activity. Preety Dixit et al Bioorg. Med. Chem. Lett. 22, 890-7, (2012)

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Synthesis and evaluation of 17?-E-20-(heteroaryl)norpregn-1,3,5(10),20 tetraene-3,17?-diols [17?-(heteroaryl)vinyl estradiols] as ligands for the estrogen receptor-? ligand binding domain (ER?-LBD). Sandra L Olmsted et al Bioorg. Med. Chem. Lett. 22, 977-9, (2012)

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Gene regulation by steroid hormones. Beato, M. Cell 56, 335-344, (1989)

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Genotoxic metabolites of estradiol in breast: potential mechanism of estradiol induced carcinogenesis. Yue, W., et al. J. Steroid Biochem. Mol. Biol. 86, 477-486, (2003)

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Advances in estrogen receptor biology: prospects for improvements in targeted breast cancer therapy. Shao, W., and Brown, M. Breast Cancer Res. 6, 39-52, (2003)

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Merck 14,3703

Beil. 6,IV,6611

Corp MSDS 1 (1), 1534:B / FT-IR 2 (3), 4237:B / FT-IR 1 (2), 1055:C / FT-NMR 1 (3), 589:B / RegBook 1 (2), 2865:K / Sax 6, 1298 / Sigma FT-IR 1 (1), 1243:D / Structure Index 1, 459:D:2