|Related Categories||Adenosine Deaminase, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, E,|
|solubility||DMSO: >10 mg/mL|
|H2O: >10 mg/mL|
|Gene Information||human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)|
Adenosine deaminase inhibitor.
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≥93% (HPLC), powder
Type X, buffered aqueous glycerol solution, ≥130 units/mg protein
Type IX, ammonium sulfate suspension, 150-200 units/mg protein
≥98% (TLC), powder
Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and/or cGMP. They function with adenylyl and guanylyl cyclases to regulate the amplitude and duration of responses triggere...
Keywords: Amplification, Atomic absorption spectroscopy, Catalysis, Diabetes, Gene expression, Genetic, Hormones, Inflammation, Neurotransmitters, Obesity, Parkinson Disease, Phosphorylations, Physiological Processes, Schizophrenia, Transduction
Dynein dysfunction disrupts intracellular vesicle trafficking bidirectionally and perturbs synaptic vesicle docking via endocytic disturbances a potential mechanism underlying age-dependent impairment of cognitive function. Kimura N, Okabayashi S, and Ono F Am. J. Pathol. 180(2), 550-61, (2012)
Adenosine activation of A(2B) receptor(s) is essential for stimulated epithelial ciliary motility and clearance. Allen-Gipson DS, Blackburn MR, Schneider DJ, et al. Am. J. Physiol. Lung Cell. Mol. Physiol. 301(2), L171-80, (2011)
The blockade of adenosine deaminase ameliorates chronic experimental colitis through the recruitment of adenosine A2A and A3 receptors. Antonioli L, Fornai M, Colucci R, et al. J. Pharmacol. Exp. Ther. 335(2), 434-42, (2010)
Influence of an adenosine deaminase inhibitor, erythro-9-(2-hydroxy-3-nonyl) adenine hydrochloride, on 5-HT2CR mRNA editing in primary cultured cortical cells. Pham NT, Tohda M, Tezuka Y, et al. Biol. Pharm. Bull. 33(3), 527-9, (2010)
Shared requirement for dynein function and intact microtubule cytoskeleton for normal surface expression of cardiac potassium channels. Loewen ME, Wang Z, Eldstrom J, et al. Am. J. Physiol. Heart Circ. Physiol. 296(1), H71-83, (2009)
The adenosine deaminase inhibitor erythro-9-[2-hydroxyl-3-nonyl]-adenine decreases intestinal permeability and protects against experimental sepsis: a prospective, randomised laboratory investigation. Kayhan N, Funke B, Conzelmann LO, et al. Critical Care 12(5), R125, (2008)
Kinetic characterization of adenosine deaminase activity in zebrafish (Danio rerio) brain. Rosemberg DB, Rico EP, Senger MR, et al. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 151(1), 96-101, (2008)
On-pump inhibition of es-ENT1 nucleoside transporter and adenosine deaminase during aortic crossclamping entraps intracellular adenosine and protects against reperfusion injury: role of adenosine A1 receptor. Abd-Elfattah AS, Ding M, Jessen ME, et al. J. Thorac. Cardiovasc. Surg. 144(1), 243-9, (2012)
Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells. Burton P, Adams DR, Abraham A, et al. Biochem. J. 432(3), 575-84, (2010)
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