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E1151 Sigma

Anti-ERAB antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Endoplasmic Reticulum-Associated Amyloid β-Peptide-Binding Protein

Properties

Related Categories Alphabetical Index, Antibodies, EO-ER, Primary Antibodies
species reactivity   human
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1-2 μg/mL using human cerebellum tissue
  western blot: 1-3 μg/mL using human SK-N-SH cells
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 27 kDa
shipped in   wet ice
storage temp.   2-8°C
Gene Information   human ... HSD17B10(3028)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 100-116 of human ERAB protein.

General description

The gene HSD17B10 (hydroxysteroid (17-β) dehydrogenase 10) encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily.

Physical form

Solution in 0.05 M sodium phosphate buffer, pH 7.5, containing 0.2% gelatin and 0.1% sodium azide

Specificity

By immunoblotting, the antibody detects native human ERAB. It does not react with mouse or rat.

Application

Anti-ERAB antibody produced in rabbit is suitable for immunohistochemistry at a working concentration of 1-2μg/mL using human cerebellum tissue with DAB detection and for immunoblotting at 1-3μg/mL using human neuroblastoma SK-N-SH cells with chemiluminescence detection.

Features and Benefits

Antibody Bioguarantee
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Biochem/physiol Actions

The gene product is a subunit of mitochondrial ribonuclease P and plays a pivotal role in in mitochondrial tRNA maturation. It catalyzes the oxidation of a wide variety of fatty acids and steroids. The gene is linked to the neuronal dysfunction associated with Alzheimer disease (AD).

Price and Availability

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