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E1276 Sigma

Monoclonal Anti-Estrogen Receptor β antibody produced in mouse

clone 9.88, ascites fluid

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Hormones, Antibodies to Steroid Hormones and Related Products,
species reactivity   human, mouse, rat
application(s)   immunoprecipitation: suitable
  western blot: 1:1,000 using recombinant human estrogen receptor beta
clone   9.88, monoclonal
antibody form   ascites fluid
isotype   IgM
mol wt   antigen mol wt 53 kDa
contains   15 mM sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... ESR2(2100)
mouse ... Esr2(13983)
rat ... Esr2(25149)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

recombinant human estrogen receptor β (ER-β).

General description

The antibody recognizes estrogen receptor β and does not cross-react with estrogen receptor α.

Antigen Background

Estrogen Receptor β encodes a member of the family of estrogen receptors and superfamily of nuclear receptor ranscription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the

Application

Monoclonal Anti-Estrogen Receptor β antibody produced in mouse was used in ELISA of PC12 cells at a working dilution of 1:1500. A dilution of 1:2000 was used in immunoblotting of PC12 whole cell lysates.

Features and Benefits

Antibody Bioguarantee
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Biochem/physiol Actions

Estrogen-Related Receptors (ERR) are hormone receptors that bind estrogen response elements that in turn bind specific DNA sequences and regulate transcription. Three ERRs are known, alpha, beta and gamma, with highly conserved ligand and DNA binding sequences. ERRβ is selectively expressed in brain and is an important modulator of energy balance, food intake, neuropeptide levels and response to stress.

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