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  • E1396 - Anti-Estrogen Receptor (154-171) antibody produced in rabbit

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E1396 Sigma

Anti-Estrogen Receptor (154-171) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Hormones, Antibodies to Steroid Hormones and Related Products,
species reactivity   human
application(s)   microarray: suitable
  western blot: 1:3,000 using cultured MCF7 cell line extract
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt 67 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... ESR1(2099)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

A synthetic peptide corresponding to amino acids 154-171 of the human estrogen receptor coupled to KLH.

General description

Human estrogen receptor (hER) is a 67kD protein that belongs to nuclear hormone receptor family and is distributed mainly in the epithelial elements of the human breast, endometrium, endocervix, vagina, ovary and fallopian tube. It facilitates the overall estrogen action and regulates the eukaryotic gene expression. It also has a pivotal role in genesis and malignant progression of breast cancer. Anti-Estrogen Receptor (154-171) antibody can be used for immunochemical detection and quantification of the receptor, independent of receptor-ligand complex. It can also be used to detect truncated estrogen receptors. Rabbit anti-Estrogen Receptor (154-171) antibody reacts specifically with human estrogen receptor (154-171).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4 containing 15 mM sodium azide.

Application

Anti-Estrogen Receptor (154-171) antibody can be used in western blotting (diluted 1: 3,000) using cultured MCF7 cell line extract. It can also be used in microarray.

Features and Benefits

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