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  • E1407 - Monoclonal Anti-Erythropoietin antibody produced in rat

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E1407 Sigma

Monoclonal Anti-Erythropoietin antibody produced in rat

clone 148438, purified immunoglobulin, lyophilized powder

Synonym: Anti-EP, Anti-EPO, Anti-Epo

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cytokines and Growth Factors, Antibodies to Hematopoietic Cytokines,
species reactivity   mouse
application(s)   neutralization: suitable
clone   148438, monoclonal
antibody form   purified immunoglobulin
form   lyophilized powder
isotype   IgG2a
storage temp.   −20°C
Gene Information   mouse ... Epo(13856)
biological source   rat
conjugate   unconjugated

Description

Immunogen

purified, CHO cell-derived recombinant mouse erythropoietin.

General description

Erythropoietin (Epo) is a pleotropic cytokine that promotes erythropoiesis or proliferation and differentiation of red blood cell precursors. Epo is mainly produced by liver cells in fetal stages, by kidneys under hypoxic conditions; liver and brain also secrete Epo is less amounts. The red blood cell production is stimulated when Epo binds and activates the Epo receptor (EpoR) dimer. EpoR directly regulates the signalling by Jak2, PI3K, NF-κB, STAT5A and STAT5B. Epo also inhibits apoptosis of erythroid progenitors by downregulating Fas and FasL. The expression of Epo is under the control of the transcription factor hypoxia inducible factor (HIF). Erythropoietin exhibits disease-modifying effects in infectious diseases and chronic inflammatory disorders
Monoclonal Anti-Erythropoietin antibody specifically reacts with mouse Erythropoietin.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Application

Monoclonal Anti-Erythropoietin antibody is suitable for neutralization reactions.

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  NONH for all modes of transport
WGK Germany  1
Protocols & Articles

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Peer-Reviewed Papers
15

References

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