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E2033 Sigma

14-3-3 Epsilon histidine-tagged human

recombinant, expressed in E. coli, C-terminal, ≥90% (SDS-PAGE), buffered aqueous solution

Synonym: 14-3-3ε, FLJ45465, KCIP-1, MDCR, MDS, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide, YWHAE

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Properties

Related Categories Apoptosis and Cell Cycle, Cell Biology, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, Cell Signaling and Neuroscience More...
recombinant   expressed in E. coli
assay   ≥90% (SDS-PAGE)
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... YWHAE(7531)

Description

Physical form

Supplied as a 0.2 μm filtered solution in 50 mM potassium phosphate buffer and 300 mM sodium chloride.

Biochem/physiol Actions

14-3-3 proteins are involved in a multitude of biological processes and exhibit a regulatory role in processes such as apoptotic cell death, mitogenic signal transduction, and cell cycle control. 14-3-3ε interacts with various proteins (cdc25 phosphatases, Raf1, and IRS1) in diverse signal trasduction pathways suggesting a role to 14-3-3ε in biological phenomenons such as cell division and regulation of insulin sensitivity. There is a growing emergence of correlative data linking 14-3-3 proteins to various human diseases such as neurodegenerative conditions, cancer, and heart diseases.

General description

14-3-3ε is a protein encoded by the YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein ε), which is a DISC1 (Disrupted-in-Schizophrenia 1)-interacting protein. It belongs to a family of highly conserved proteins called 14-3-3, which has seven isoforms namely, σ, β, γ, ε, τ, θ, and η. They also contain two isotypes, α and δ, which are phosphorylated. 14-3-3ε is expressed in human brain, and is the oldest isoform of this family.

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Flow Cytometry Instruments
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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