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  • E2278 - E-Cadherin/Fc Chimera human

E2278 Sigma

E-Cadherin/Fc Chimera human

≥90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym: L-CAM, Arc-1, Cell-CAM120/80, Epithelial cadherin, Uvomorulin



Physical form

Lyophilized from a 0.2 μm filtered solution in 50 mM Tris-Citrate, 250 mM NaCl, and 2 mM CaCl2 pH 6.5.

Biochem/physiol Actions

E (epithelial)-cadherin is involved in hemophilic cell-cell adhesion in a calcium-dependent manner. It forms adheren junctions through its ectodomains, to maintain physical contacts between adjacent cells. It plays essential roles in developmental processes, tissue homeostasis and multiple diseases. In humans, this protein might be involved in the pathophysiology of ulcerative colitis. In Crohn′s dieases patients, mutations in this gene lead to a truncated or mislocalized protein product. Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) are the underlying processes of tumorigenesis and embryogenesis, and these involve the control of E-cadherin expression.

General description

E (epithelial)-cadherin is a type I classical cadherin, which exists as a dimer. It has an ectodomain made of five extracellular cadherin-like (EC) domains, connected by conserved linker regions, which are calcium-binding in nature. It spans the membrane once, and contains a cytoplasmic region. It is a glycoprotein, and in humans has a molecular weight of 120kDa. It binds to catenin and cytoskeletal protein with its C-terminal domain.

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Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Protocols & Articles

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