|Related Categories||Adenosines/P2 Nucleotide Receptor - Agonists, Adenosines/P2 Nucleotide Receptors (Purinergics), Agonists, Bioactive Small Molecules, Biochemicals and Reagents,|
45% (w/v) aq 2-hydroxypropyl-β-cyclode|
|DMSO: soluble14 mg/mL (Solutions may be stored for several days at 4 °C.)|
|0.1 M HCl: soluble3.4 mg/mL (Solutions may be stored for several days at 4 °C.)|
|ethanol: soluble (Solutions may be stored for several days at 4 °C.)|
human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)|
rat ... Adora1(29290), Adora2a(25369), Adora2b(29316), Adora3(25370)
Potent adenosine receptor agonist with nearly equal affinity at A1 and A2 receptors.
Certificate of Analysis
|Precautionary statements||P264-P301 + P310|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T+|
|Risk Statements (Europe)||28|
|Safety Statements (Europe)||22-26-36-45|
|RIDADR||UN 2811 6.1 / PGII|
There are four known subtypes of adenosine receptors, referred to as A1, A2A, A2B and A3. All are members of the superfamily of G protein-coupled receptors and each bears the characteristic motif of ...
Keywords: Atomic absorption spectroscopy, Cancer, Cardiovascular, Diabetes, Diseases, Gene expression, Inflammation, Neurotransmitters, Substitutions, Transduction
G protein-coupled receptors (GPCRs) are the largest class of transmembrane proteins and the targets for almost half of the clinical drugs in the market today. Advances in X-ray crystallography and ot...
Mike Earley, Market Segment Manager, Sigma Life Science
Biofiles Vol. 8, No. 4
Keywords: Clinical, Confocal microscopy, Ligands, Microscopy
Adenosine-a selective neuromodulator in the mammalian CNS? Williams Trends Neurosci. 7, 1, (1984)
Novel effects of adenosine receptors on pericellular hyaluronan matrix: implications for human smooth muscle cell phenotype and interactions with monocytes during atherosclerosis. Grandoch M, Hoffmann J, Röck K, et al. Basic Res. Cardiol. 108(2), 340, (2013)
Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ. Nayeem MA, Pradhan I, Mustafa SJ, et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 304(1), R23-32, (2013)
CYP-epoxygenases contribute to A2A receptor-mediated aortic relaxation via sarcolemmal KATP channels. Ponnoth DS, Nayeem MA, Tilley SL, et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 303(10), R1003-10, (2012)
Downregulation of A(1) and A(2B) adenosine receptors in human trisomy 21 mesenchymal cells from first-trimester chorionic villi. Gessi S, Merighi S, Stefanelli A, et al. Biochim. Biophys. Acta 1822(11), 1660-70, (2012)
Adora2b adenosine receptor engagement enhances regulatory T cell abundance during endotoxin-induced pulmonary inflammation. Ehrentraut H, Westrich JA, Eltzschig HK, et al. PLoS ONE 7(2), e32416, (2012)
Loss of adenosine A2B receptor mediated relaxant responses in the aged female rat bladder; effects of dietary phytoestrogens. Owen SJ, Massa HH, and Rose'Meyer RB Naunyn Schmiedebergs Arch. Pharmacol. 385(5), 539-49, (2012)
The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion. Chin A, Svejda B, Gustafsson BI, et al. Am. J. Physiol. Gastrointest. Liver Physiol. 302(3), G397-405, (2012)
Purinergic regulation of high-glucose-induced caspase-1 activation in the rat retinal Müller cell line rMC-1. Trueblood KE, Mohr S, and Dubyak GR Am. J. Physiol. Cell Physiol. 301(5), C1213-23, (2011)
Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics. May LT, Bridge LJ, Stoddart LA, et al. FASEB J. 25(10), 3465-76, (2011)
Adenosine activation of A(2B) receptor(s) is essential for stimulated epithelial ciliary motility and clearance. Allen-Gipson DS, Blackburn MR, Schneider DJ, et al. Am. J. Physiol. Lung Cell. Mol. Physiol. 301(2), L171-80, (2011)
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