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E2520 Sigma

Monoclonal Anti-Epidermal Growth Factor antibody produced in mouse

clone EGF-10, purified immunoglobulin, buffered aqueous solution

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, Antibodies to Cytokines and Growth Factors,
species reactivity   human
application(s)   dot blot: 0.1 μg/mL using recombinant human EGF
  immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable using human tissue
  indirect ELISA: suitable
  microarray: suitable
  neutralization: suitable
  radioimmunoassay: suitable
  western blot: suitable
clone   EGF-10, monoclonal
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG1
mol wt   antigen mol wt 6 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... EGF(1950)
biological source   mouse
conjugate   unconjugated
Featured Industry   Research Pathology

Description

Immunogen

recombinant human EGF

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4

Specificity

Specifically reacts with both native and recombinant human EGF. The antibody does not cross-react with mouse EGF.

Application

Monoclonal Anti-Epidermal Growth Factor antibody produced in mouse was used to study rat immune cells by flow cytometry to detect the presence or absence of hormone and hormone-like molecules in response to EGF treatment.

Features and Benefits

Antibody Bioguarantee
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Biochem/physiol Actions

EGFR is a transmembrane glycoprotein that binds to the EGF family. It is a pivotal regulator of cell proliferation, growth, differentiation and DNA repair after radiation-induced damage. Mutations in the gene encoding EGFR are associated with a number of malignancies including lung cancer and colorectal cancer.

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Safety & Documentation

Safety Information

Personal Protective Equipment  Eyeshields, Gloves
RIDADR  NONH for all modes of transport
WGK Germany  3
Protocols & Articles

Articles

EGF Signaling: Tracing Cancer's Path

The epidermal growth factor (EGF) family is a group of structurally related proteins that regulate cell proliferation, migration and differentiation via tyrosine kinase receptors on target cells. The...
Keywords: Apoptosis, Cancer, Cell proliferation, Cloning, Gene expression, Growth factors, Ligands, Morphogenesis, Phosphorylations, Transcription, Transduction, transformation

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Antibody Explorer | Buy Primary & Secondary Antibodies

Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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E1157 Anti-Epidermal Growth Factor Receptor/Erb B1 antibody produced in goat, affinity isolated antibody, lyophilized powder

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Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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