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E2643 Sigma

Enterostatin human

≥97% (HPLC)

  • Empirical Formula (Hill Notation) C21H36N8O6

  • Molecular Weight 496.56

  •  MDL number MFCD00133052

  •  PubChem Substance ID 329799035

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Description

Amino Acid Sequence

Ala-Pro-Gly-Pro-Arg

Biochem/physiol Actions

Peptide that inhibits fat intake in experiments involving dietary choice.

Studies show that peripheral and central injection of enterostatin reduces the food intake. In Sprague-Dawley rats, central injection leads to a reduction in the intake of high-fat food as opposed to low-fat food. Therefore, it might have a role in the feedback loop of dietary fat. In a chronic manner, it is responsible for the reduction of body fat, intake of fat and body weight. It controls the secretory activity of β-cells of pancreas, and suppresses insulin secretion without affecting the secretion of glucagon and somatostatin. It might also have anti-incretin activity in the enteroinsular axis, and might regulate postprandial hyperinsulinemia.

Application

Enterostatin human maybe used to study the hydrolytic activity of human angiotensin-converting enzyme-related carboxypeptidase (ACE2) on human biological peptides.

General description

Enterostatin is a pentapeptide Val-Pro-Asp-Pro-Arg (VPDPR) obtained from trypsin digestion of procolipase, which is a pancreatic lipase. It is produced by the intestine, and the gastric mucosa.

Price and Availability


Amplified Detection

All labs need water

Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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