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  • E2764 - Anti-Endothelin Receptor B antibody produced in rabbit

E2764 Sigma

Anti-Endothelin Receptor B antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym: Anti-ET-B, Anti-ET-Specific Endothelin Receptor



Related Categories Alphabetical Index, Antibodies, Antibodies for Neurotransmission, Antibodies to Neurotransmitter Receptors, EJ-EN,
species reactivity   rat
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100
  western blot (chemiluminescent): 1:200
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
shipped in   dry ice
storage temp.   −20°C
Gene Information   rat ... Ednrb(50672)
biological source   rabbit
conjugate   unconjugated



synthetic peptide corresponding to amino acids 298-313 of rat endothelin receptor type B. The epitope is identical in all known vertebrate ET-B receptors

Physical form

Lyophilized at 0.8 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide


Anti-Endothelin Receptor B antibody produced in rabbit is suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a dilution of 1:100 and western blotting (chemiluminescent) at a dilution of 1:200.

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Biochem/physiol Actions

EDNRB Endothelin receptor type B (ETB) is a protein encoded by the EDNRB gene in humans. It plays a pivotal role in oesophageal cancer and may act as a therapeutic target for this intractable malignancy. It has a novel role in oligodendroglioma proliferation and acts as a potential therapeutic alternative for oligodendrogliomas. Lower expression of ETB receptor responsiveness is associated with polycystic ovary syndrome (PCOS) and may reflect lower endothelial-mediated vasodilatation independent of generally lower vascular reactivity.

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Safety Information

Symbol  GHS07  GHS07
Signal word  Warning
Hazard statements  H315-H319-H335-H412
Precautionary statements  P261-P273-P305 + P351 + P338
RIDADR  NONH for all modes of transport
WGK Germany  3
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