|Related Categories||A to C, Acetylcholinesterase, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents,|
|Gene Information||human ... ACHE(43)|
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Acetylcholine is synthesized from acetyl coenzyme A and choline by the enzyme choline acetyltransferase. In the nervous system, this enzyme is thought to exist primarily in the nerve terminal cytopla...
Keywords: Clinical, Enzyme activity, Insecticides, Phosphorylations, Transcription
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BioFiles v7 n5, 2012, 5–20
Keywords: AGE, Antihypertensives, Cardiovascular, Clinical, Diuretics, Pharmaceutical, Reductions
Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer methylene blue. Triquigneaux MM, Ehrenshaft M, Roth E, et al. Biochem. J. 448(1), 83-91, (2012)
Failure to reverse prolonged vecuronium-induced neuromuscular blockade with edrophonium in an anesthetized dog. Martin-Flores M, Boesch J, Campoy L, et al. J. Am. Anim. Hosp. Assoc. 47(4), 294-8, (2011)
Multiple inhibitory actions of lidocaine on Torpedo nicotinic acetylcholine receptors transplanted to Xenopus oocytes. Alberola-Die A, Martinez-Pinna J, González-Ros JM, et al. J. Neurochem. 117(6), 1009-19, (2011)
Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment. Marketa Komloova et al Bioorg. Med. Chem. Lett. 21, 2505-9, (2011)
Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors. Pisani L, Catto M, Giangreco I, et al. ChemMedChem 5(9), 1616-30, (2010)
Rapid chemical antagonism of neuromuscular blockade by L-cysteine adduction to and inactivation of the olefinic (double-bonded) isoquinolinium diester compounds gantacurium (AV430A), CW 002, and CW 011. Savarese JJ, McGilvra JD, Sunaga H, et al. Anesthesiology 113(1), 58-73, (2010)
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