Epidermal Growth Factor Receptor human
buffered aqueous glycerol solution, 5,000-30,000 units/mg protein (Lowry)
DOWNLOAD MSDS (PDF)Synonym: EGFR
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MDL number MFCD01634808
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Popular Documents: Product Information Sheet (PDF) | Specification Sheet (PDF)
Properties
| Related Categories | Application Index, Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, |
| Quality Level | PREMIUM |
| form | buffered aqueous glycerol solution |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... EGFR(1956) |
Description
Preparation Note
Affinity purified from human carcinoma A431 cells
Unit Definition
One unit will catalyze the incorporation of 1 pmol of phosphate from γ-32P-ATP into poly (Glu,Tyr), 4:1 at 30 °C per min.
Physical form
Solution in 50% glycerol, containing 50 mM HEPES, pH 7.6, 150 mM NaCl, 0.1% Triton and 1 mM dithiothreitol
Biochem/physiol Actions
EGF exerts its actions by binding to the EGF receptor (EGFR), a 170 kDa glycoprotein having EGF-activated protein tyrosine kinase activity. Even in the absence of EGF-like ligands, EGFR can participate in cellular responses elicited by several other stimuli. High levels of EGFR are expressed in approximately one third of human epithelial tumors, and in the cancers of the bladder, breast or lung that have poor clinical prognosis, hence the interest in targeting EGFR.
Price and Availability
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