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E3651 Sigma

Anti-Endothelin Receptor A antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym: Anti-ET-A, Anti-ET1-Specific Endothelin Receptor

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Neurotransmission, Antibodies to Neurotransmitter Receptors, EJ-EN,
species reactivity   bovine, chicken, pig, human
application(s)   immunohistochemistry: 1:100 using rat brain sections or rat lung paraffin embedded sections
  western blot: 1:200 using rat brain membranes and ECL
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... EDNRA(1909)
rat ... Ednra(24326)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 413-426 of rat ET-A (with additional N-terminal cysteine).

Physical form

Lyophilized from a solution of phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Specificity

The epitope is highly conserved in human, swine, bovine and chicken ET-A.

Application

Anti-Endothelin Receptor A antibody produced in rabbit is suitable for immunohistochemistry at a dilution of 1:100 using rat brain sections or rat lung paraffin embedded sections and western blotting at a dilution of 1:200 using rat brain membranes and ECL.

Features and Benefits

Antibody Bioguarantee
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Biochem/physiol Actions

Endothelin receptor type A (ETA, ETAR) is a human G protein-coupled receptor that mediates vasoconstriction of blood vessels. It is involved in tumor cell invasion, survival and metastasis. ETAR mediates the promotion of ET-1 on colon cancer cell survival, invasion and MMP-2 expression by a PI3K-mediated mechanism. It plays a critical role in colon cancer metastasis.

Price and Availability


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