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E3651 Sigma

Anti-Endothelin Receptor A antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym: Anti-ET-A, Anti-ET1-Specific Endothelin Receptor

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Neurotransmission, Antibodies to Neurotransmitter Receptors, EJ-EN,
species reactivity   bovine, chicken, pig, human
application(s)   immunohistochemistry: 1:100 using rat brain sections or rat lung paraffin embedded sections
  western blot: 1:200 using rat brain membranes and ECL
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... EDNRA(1909)
rat ... Ednra(24326)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 413-426 of rat ET-A (with additional N-terminal cysteine).

Physical form

Lyophilized from a solution of phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Specificity

The epitope is highly conserved in human, swine, bovine and chicken ET-A.

Application

Anti-Endothelin Receptor A antibody produced in rabbit is suitable for immunohistochemistry at a dilution of 1:100 using rat brain sections or rat lung paraffin embedded sections and western blotting at a dilution of 1:200 using rat brain membranes and ECL.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Features and Benefits

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Biochem/physiol Actions

Endothelin receptor type A (ETA, ETAR) is a human G protein-coupled receptor that mediates vasoconstriction of blood vessels. It is involved in tumor cell invasion, survival and metastasis. ETAR mediates the promotion of ET-1 on colon cancer cell survival, invasion and MMP-2 expression by a PI3K-mediated mechanism. It plays a critical role in colon cancer metastasis.

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Safety & Documentation

Safety Information

Hazard statements  H412
Precautionary statements  P273
RIDADR  NONH for all modes of transport
WGK Germany  3
Protocols & Articles

Related Content

Antibody Explorer | Buy Primary & Secondary Antibodies

Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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