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E3888 Sigma

[D-Pen2,5]-Enkephalin hydrate

≥95% (HPLC)

Synonym: DPDPE

  • Empirical Formula (Hill Notation) C30H39N5O7S2 · xH2O

  • Molecular Weight 645.79 (anhydrous basis)

  •  MDL number MFCD00076430

  •  PubChem Substance ID 329799055

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Enkephalins, Neuropeptides, Opioid Peptides,
InChI Key   MCMMCRYPQBNCPH-WMIMKTLMSA-N
assay   ≥95% (HPLC)
storage temp.   −20°C

Description

Amino Acid Sequence

Tyr-Pen-Gly-Phe-Pen [Disulfide Bridge: 2-5]

Other Notes

Lyophilized from 0.1% TFA in H2O

Packaging

1, 5 mg in serum bottle

Application

[D-Pen2,5]-Enkephalin hydrate (DPDPE) has been used to study the pharmacodynamic and pharmacokinetic capabilities of polyethylene glycol (PEG) conjugate of DPDPE in rodents. It has been used to study the tendency of opiate self-administration in male Long-Evans rats, in ventral tegmental area (VTA).

Biochem/physiol Actions

Antinociceptive activity mediated through the δ1 receptor while the modulatory activity is mediated through the δ2 receptor. Tritiated [D-Pen2,5]-enkephalin is used as a δ1 ligand.

General description

[D-Pen2,5]-Enkephalin hydrate, also called DPDPE, is a peptide and acts as a δ1-opioid receptor agonist. Opioid receptors are divided into three types called, μ, κ and δ, depending upon their ligands. These ligands are peptides and are classified as enkephalins, endorphins and dynorphins.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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