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  • E4141 - Monoclonal Anti-S1P3, C-Terminal antibody produced in mouse

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E4141 Sigma

Monoclonal Anti-S1P3, C-Terminal antibody produced in mouse

clone AS61, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-EDG-3, Anti-Endothelial Cell Differentiation Gene 3, C-Terminal

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Lipids in Cell Signaling, Primary Antibodies,
species reactivity   rat, human
application(s)   western blot: 1:10,000 using human and rat spleen and lung tissue
clone   AS61, monoclonal
concentration   ~1 mg/mL
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG
mol wt   antigen mol wt 45 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... S1PR3(1903)
rat ... Edg3l(29736)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

human EDG-3/S1P3 unique C-terminal peptide.

Physical form

Solution in phosphate buffered saline with 0.08% sodium azide.

Application

Monoclonal Anti-S1P3, C-Terminal antibody produced in mouse is suitable for western blotting at a dilution of 1:10,000 using human and rat spleen and lung tissue.

Features and Benefits

Antibody Bioguarantee
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Biochem/physiol Actions

Sphingosine-1-phosphate receptor 3 also known as S1PR3 is a human gene which encodes a G protein-coupled receptor. It binds the lipid signaling molecule sphingosine 1-phosphate (S1P). S1PR3 acts as a critical signaling molecule mediating cell proliferation and vascular permeability. It acts as a potential biomarker in murine and human acute lung injury (ALI). Sphingosine 1-phosphate (S1P) and the S1P receptor S1PR3 are intimately involved in lung inflammatory responses and vascular barrier regulation. S1PR3 serves as a biomarker of severity in critically acute respiratory distress syndrome (ARDS) patients and can act as a potential target for individualized therapy.

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